Gender-specific metabolic responses in gonad of mussel Mytilus galloprovincialis to 2,2 ',4,4 '-tetrabromodiphenyl ether

doi:10.1016/j.etap.2014.04.007

	Gender-specific metabolic responses in gonad of mussel Mytilus galloprovincialis to 2,2 ',4,4 '-tetrabromodiphenyl ether
	Ji, Chenglong1,2 ; Zhao, Jianmin1 ; Wu, Huifeng1 ; Wu, HF (reprint author), Chinese Acad Sci, Shandong Prov Key Lab Coastal Zone Environm Proc, YICCAS, Yantai Inst Coastal Zone Res YIC,Key Lab Coastal, Yantai 264003, Peoples R China. [email protected]
发表期刊	ENVIRONMENTAL TOXICOLOGY AND PHARMACOLOGY
ISSN	1382-6689
	2014-05-01
卷号	37 期号:3 页码:1116-1122
关键词	Bde 47 Mytilus Galloprovincialis Toxicological Effects Nmr Metabolomics
DOI	10.1016/j.etap.2014.04.007
产权排序	[Ji, Chenglong; Zhao, Jianmin; Wu, Huifeng] Chinese Acad Sci, Shandong Prov Key Lab Coastal Zone Environm Proc, YICCAS, Yantai Inst Coastal Zone Res YIC,Key Lab Coastal, Yantai 264003, Peoples R China; [Ji, Chenglong] Univ Chinese Acad Sci, Beijing 100049, Peoples R China
作者部门	中科院海岸带环境过程与生态修复重点实验室
英文摘要	Polybrominated diphenyl ethers (PBDEs) are widely used as a class of brominated flame-retardants. As a congener of PBDEs, 2,2',4,4'-tetrabromodiphenylether (BDE 47) is the most toxic congener to animals. In this study, we applied metabolomics to characterize the gender-specific metabolic responses in mussel Mytilus galloprovincialis exposed to BDE 47 for 30 days. Results indicated the apparent gender-specific responses in M. galloprovincialis with BDE 47 exposures (1 and 10 mu g/L) at metabolite level. Basically, BDE 47 induced disruption in osmotic regulation and altered energy metabolism in mussels, via differential metabolic pathways. In addition, the hormesis phenomenon was observed in both male and female mussel samples exposed the two concentrations of BDE 47, indicated by the contrarily altered metabolites from two BDE 47 treatments (1 and 10 mu g/L), respectively. Overall, this study confirmed the gender-specific responses to BDE 47 exposures in mussels and suggested the gender differences should be considered in marine ecotoxicology. (C) 2014 Elsevier B.V. All rights reserved.; Polybrominated diphenyl ethers (PBDEs) are widely used as a class of brominated flame-retardants. As a congener of PBDEs, 2,2',4,4'-tetrabromodiphenylether (BDE 47) is the most toxic congener to animals. In this study, we applied metabolomics to characterize the gender-specific metabolic responses in mussel Mytilus galloprovincialis exposed to BDE 47 for 30 days. Results indicated the apparent gender-specific responses in M. galloprovincialis with BDE 47 exposures (1 and 10 mu g/L) at metabolite level. Basically, BDE 47 induced disruption in osmotic regulation and altered energy metabolism in mussels, via differential metabolic pathways. In addition, the hormesis phenomenon was observed in both male and female mussel samples exposed the two concentrations of BDE 47, indicated by the contrarily altered metabolites from two BDE 47 treatments (1 and 10 mu g/L), respectively. Overall, this study confirmed the gender-specific responses to BDE 47 exposures in mussels and suggested the gender differences should be considered in marine ecotoxicology. (C) 2014 Elsevier B.V. All rights reserved.
文章类型	Article
资助机构	Environmental Sciences & Ecology ; Pharmacology & Pharmacy ; Toxicology
收录类别	SCI
语种	英语
关键词[WOS]	POLYBROMINATED DIPHENYL ETHERS ; ENVIRONMENTALLY RELEVANT CONCENTRATIONS ; CLAM RUDITAPES-PHILIPPINARUM ; NMR-BASED METABOLOMICS ; EXPOSURE ; SAMPLES ; CELLS ; BDE-47 ; HEALTH ; GILLS
研究领域[WOS]	Environmental Sciences & Ecology ; Pharmacology & Pharmacy ; Toxicology
WOS记录号	WOS:000338598200024
引用统计	被引频次：12[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	http://ir.yic.ac.cn/handle/133337/8748
专题	中国科学院海岸带环境过程与生态修复重点实验室海岸带生物学与生物资源利用重点实验室_海岸带生物学与生物资源保护实验室
通讯作者	Wu, HF (reprint author), Chinese Acad Sci, Shandong Prov Key Lab Coastal Zone Environm Proc, YICCAS, Yantai Inst Coastal Zone Res YIC,Key Lab Coastal, Yantai 264003, Peoples R China. [email protected]
作者单位	1.Chinese Acad Sci, Shandong Prov Key Lab Coastal Zone Environm Proc, YICCAS, Yantai Inst Coastal Zone Res YIC,Key Lab Coastal, Yantai 264003, Peoples R China 2.Univ Chinese Acad Sci, Beijing 100049, Peoples R China
推荐引用方式 GB/T 7714	Ji, Chenglong,Zhao, Jianmin,Wu, Huifeng,et al. Gender-specific metabolic responses in gonad of mussel Mytilus galloprovincialis to 2,2 ',4,4 '-tetrabromodiphenyl ether[J]. ENVIRONMENTAL TOXICOLOGY AND PHARMACOLOGY,2014,37(3):1116-1122.
APA	Ji, Chenglong,Zhao, Jianmin,Wu, Huifeng,&Wu, HF .(2014).Gender-specific metabolic responses in gonad of mussel Mytilus galloprovincialis to 2,2 ',4,4 '-tetrabromodiphenyl ether.ENVIRONMENTAL TOXICOLOGY AND PHARMACOLOGY,37(3),1116-1122.
MLA	Ji, Chenglong,et al."Gender-specific metabolic responses in gonad of mussel Mytilus galloprovincialis to 2,2 ',4,4 '-tetrabromodiphenyl ether".ENVIRONMENTAL TOXICOLOGY AND PHARMACOLOGY 37.3(2014):1116-1122.