Experimental study of a heparin-coated venous stent fabricated by atomic layer deposition

doi:10.1177/08853282221126575

	Experimental study of a heparin-coated venous stent fabricated by atomic layer deposition
	Li, Xiaoying 1; Zhang, Kunpeng 2; Jiang, Xiaorui 2; Wang, Lei3 ; Zhang, Tao 4; Zhang, Xiaoming 5; Che, Haijie 2
发表期刊	JOURNAL OF BIOMATERIALS APPLICATIONS
ISSN	0885-3282
	2022-09-23
页码	11
关键词	venous stent heparin-coated experimental study atomic layer deposition technology vascular endothelialization endovascular stent surface modification
DOI	10.1177/08853282221126575
通讯作者	Che, Haijie([email protected])
英文摘要	Objective To evaluate the safety and efficacy of heparin-coated venous stents in animals. Methods We used atomic layer deposition technology to obtain a heparin coating with good stability and then prepared a heparin-coated venous stent based on this technology. The experimental stents were prepared according to the diameter of the rabbit inferior vena cava and were divided into Ni-Ti alloy stent group, Ni-Ti-Al2O3 stent group and Ni-Ti-Al2O3-Heparin stent group. 3 days, 7 days and 14 days after stent implantation, the materials were collected, and the three groups of stents were observed by hard tissue section pathology, immunohistochemistry and scanning electron microscope to observe the differences in vascular wall inflammation, thrombosis, lumen stenosis and vascular intima regeneration. Result and Conclusion The experiment confirmed the safety of the heparin-coated stent in vivo. Compared with the control group, the experimental group showed a high degree of vascular endothelialization and an intact neointimal structure 14 days after implantation. The long-term safety and biological effects of heparin-coated venous stents in animals require further study.
资助机构	Shandong Province Major Science and Technology Innovation Project
收录类别	SCI
语种	英语
关键词[WOS]	TRANSLUMINAL CORONARY ANGIOPLASTY ; ELASTIC RECOIL ; RESTENOSIS ; BIOFUNCTIONALIZATION ; ENDOTHELIALIZATION ; SULFATE ; CELLS ; MODEL
研究领域[WOS]	Engineering ; Materials Science
WOS记录号	WOS:000860933900001
引用统计	被引频次：1[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	http://ir.yic.ac.cn/handle/133337/37314
专题	中国科学院烟台海岸带研究所知识产出
通讯作者	Che, Haijie
作者单位	1.Yantai Qishan Hosp, Yantai, Peoples R China 2.Qingdao Univ, YanTai Yuhuangding Hosp, 20 Yuhuangding East Rd, Yantai 264000, Peoples R China 3.Yantai Inst Coastal Zone Res, Yantai, Peoples R China 4.Nanjing Univ, Nanjing, Peoples R China 5.Peking Univ Peoples Hosp, Beijing, Peoples R China
推荐引用方式 GB/T 7714	Li, Xiaoying,Zhang, Kunpeng,Jiang, Xiaorui,et al. Experimental study of a heparin-coated venous stent fabricated by atomic layer deposition[J]. JOURNAL OF BIOMATERIALS APPLICATIONS,2022:11.
APA	Li, Xiaoying.,Zhang, Kunpeng.,Jiang, Xiaorui.,Wang, Lei.,Zhang, Tao.,...&Che, Haijie.(2022).Experimental study of a heparin-coated venous stent fabricated by atomic layer deposition.JOURNAL OF BIOMATERIALS APPLICATIONS,11.
MLA	Li, Xiaoying,et al."Experimental study of a heparin-coated venous stent fabricated by atomic layer deposition".JOURNAL OF BIOMATERIALS APPLICATIONS (2022):11.