Synthesis and characterization of novel carboxymethyl inulin derivatives bearing cationic Schiff bases with antioxidant potential

doi:10.1016/j.ijbiomac.2024.133761

	Synthesis and characterization of novel carboxymethyl inulin derivatives bearing cationic Schiff bases with antioxidant potential
	Chen, Yuan 1; Zhang, Hongwu 1; Chen, Qiuhong 2; Mi, Yingqi 2,3; Guo, Zhanyong2
发表期刊	INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
ISSN	0141-8130
	2024-08-01
卷号	275 页码:11
关键词	Carboxymethyl inulin Schiff base Antioxidant activity Cytotoxicity
DOI	10.1016/j.ijbiomac.2024.133761
通讯作者	Mi, Yingqi([email protected]) ; Guo, Zhanyong([email protected])
英文摘要	This study aimed to enhance the antioxidant activity of carboxymethyl inulin (CMI) by chemical modification. Therefore, a series of cationic Schiff bases bearing heteroatoms were synthesized and incorporated into CMI via ion exchange reactions, ultimately preparing 10 novel CMI derivatives (CMID). Their structures were confirmed by Fourier transform infrared (FTIR) and nuclear magnetic resonance (NMR) spectroscopy. The radical scavenging activities and reducing power of inulin, CMI, and CMID were studied. The results revealed a significant enhancement in antioxidant activity upon the introduction of cationic Schiff bases into CMI. Compared to commercially available antioxidant Vc, CMID demonstrated a broader range of antioxidant activities across the four antioxidant systems analyzed in this research. In particular, CMID containing quinoline (6QSCMI) exhibited the strongest hydroxyl radical scavenging activity, with a scavenging rate of 93.60 % at 1.6 mg mL- 1. The CMID bearing imidazole (2MSCMI) was able to scavenge 100 % of the DPPH radical at 1.60 mg mL- 1. Furthermore, cytotoxicity experiments showed that the products had good biocompatibility. These results are helpful for evaluating the feasibility of exploiting these products in the food, biomedical, and cosmetics industries.
资助机构	Natural Science Foundation of Shandong Province of China ; China Post-doctoral Science Foundation
收录类别	SCI
语种	英语
关键词[WOS]	OXIDATIVE STRESS ; COMPLEXES
研究领域[WOS]	Biochemistry & Molecular Biology ; Chemistry ; Polymer Science
WOS记录号	WOS:001288611900001
引用统计
文献类型	期刊论文
条目标识符	http://ir.yic.ac.cn/handle/133337/35829
专题	海岸带生物学与生物资源利用重点实验室海岸带生物学与生物资源利用重点实验室_海岸带生物资源高效利用研究与发展中心
通讯作者	Mi, Yingqi; Guo, Zhanyong
作者单位	1.Ludong Univ, Coll Chem & Mat Sci, Yantai 264025, Peoples R China 2.Chinese Acad Sci, Key Lab Coastal Biol & Bioresource Utilizat, Yantai Inst Coastal Zone Res, Yantai 264003, Peoples R China 3.Univ Chinese Acad Sci, Beijing 100049, Peoples R China
推荐引用方式 GB/T 7714	Chen, Yuan,Zhang, Hongwu,Chen, Qiuhong,et al. Synthesis and characterization of novel carboxymethyl inulin derivatives bearing cationic Schiff bases with antioxidant potential[J]. INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES,2024,275:11.
APA	Chen, Yuan,Zhang, Hongwu,Chen, Qiuhong,Mi, Yingqi,&Guo, Zhanyong.(2024).Synthesis and characterization of novel carboxymethyl inulin derivatives bearing cationic Schiff bases with antioxidant potential.INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES,275,11.
MLA	Chen, Yuan,et al."Synthesis and characterization of novel carboxymethyl inulin derivatives bearing cationic Schiff bases with antioxidant potential".INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES 275(2024):11.