Synergistic collaboration between AMPs and non-direct antimicrobial cationic peptides

doi:10.1038/s41467-024-51730-x

	Synergistic collaboration between AMPs and non-direct antimicrobial cationic peptides
	Ye, Zifan 1; Fu, Lei 2; Li, Shuangyu 1; Chen, Ziying 2; Ouyang, Jianhong 1; Shang, Xinci 1; Liu, Yanli 1; Gao, Lianghui 2; Wang, Yipeng1,3
发表期刊	NATURE COMMUNICATIONS
	2024-08-25
卷号	15 期号:1 页码:26
DOI	10.1038/s41467-024-51730-x
通讯作者	Gao, Lianghui([email protected]) ; Wang, Yipeng([email protected])
英文摘要	Non-direct antimicrobial cationic peptides (NDACPs) are components of the animal innate immune system. But their functions and association with antimicrobial peptides (AMPs) are incompletely understood. Here, we reveal a synergistic interaction between the AMP AW1 and the NDACP AW2, which are co-expressed in the frog Amolops wuyiensis. AW2 enhances the antibacterial activity of AW1 both in vitro and in vivo, while mitigating the development of bacterial resistance and eradicating biofilms. AW1 and AW2 synergistically damage bacterial membranes, facilitating cellular uptake and interaction of AW2 with the intracellular target bacterial genomic DNA. Simultaneously, they trigger the generation of ROS in bacteria, contributing to cell death upon reaching a threshold level. Moreover, we demonstrate that this synergistic antibacterial effect between AMPs and NDACPs is prevalent across diverse animal species. These findings unveil a robust and previously unknown correlation between AMPs and NDACPs as a widespread antibacterial immune defense strategy in animals. Antimicrobial peptides and non-direct antimicrobial cationic peptides are secreted in response to invasive pathogens. Here, Ye et al show that there is a synergistic interaction between these two types of expressed peptides from the amphibian frog Amolops wuyiensis.
资助机构	National Natural Science Foundation of China (National Science Foundation of China) ; National Natural Science Foundation of China ; Key Research & Development Plan in Social Development of Jiangsu Province ; Suzhou Agricultural Science and Technology Innovation Project ; Guizhou Provincial Science and Technology Projects ; Qiankehe Support [2021] General ; Suzhou International Joint Laboratory for Diagnosis and Treatment of Brain Diseases ; Priority Academic Program Development of the Jiangsu Higher Education Institutes (PAPD)
收录类别	SCI
语种	英语
关键词[WOS]	ESCHERICHIA-COLI ; ANTIBIOTIC-RESISTANCE ; KLEBSIELLA-PNEUMONIAE ; SYNTHETIC PEPTIDE ; BIOFILM FORMATION ; OXIDATIVE STRESS ; SKIN ; CELL ; CATHELICIDINS ; IDENTIFICATION
研究领域[WOS]	Science & Technology - Other Topics
WOS记录号	WOS:001298087400008
引用统计
文献类型	期刊论文
条目标识符	http://ir.yic.ac.cn/handle/133337/35801
专题	海岸带生物学与生物资源利用重点实验室海岸带生物学与生物资源利用重点实验室_海岸带生物学与生物资源保护实验室
通讯作者	Gao, Lianghui; Wang, Yipeng
作者单位	1.Soochow Univ, Coll Pharmaceut Sci, Dept Biopharmaceut Sci, Suzhou, Jiangsu, Peoples R China 2.Beijing Normal Univ, Coll Chem, Key Lab Theoret & Computat Photochem, Minist Educ, Beijing, Peoples R China 3.Chinese Acad Sci, Yantai Inst Coastal Zone Res, Yantai, Peoples R China
推荐引用方式 GB/T 7714	Ye, Zifan,Fu, Lei,Li, Shuangyu,et al. Synergistic collaboration between AMPs and non-direct antimicrobial cationic peptides[J]. NATURE COMMUNICATIONS,2024,15(1):26.
APA	Ye, Zifan.,Fu, Lei.,Li, Shuangyu.,Chen, Ziying.,Ouyang, Jianhong.,...&Wang, Yipeng.(2024).Synergistic collaboration between AMPs and non-direct antimicrobial cationic peptides.NATURE COMMUNICATIONS,15(1),26.
MLA	Ye, Zifan,et al."Synergistic collaboration between AMPs and non-direct antimicrobial cationic peptides".NATURE COMMUNICATIONS 15.1(2024):26.