| 一种酚酸酯化壳寡糖季铵盐及其制备方法和应用 |
| 其他名称 | The invention discloses a phenolic acid esterified chitosan oligosaccharide quaternary ammonium salt and a preparation method and application thereof
|
| 专利类型 | 发明
|
| 专利号 | 2022109711126
|
| 郭占勇 ; 孙艳; 崔静敏
|
| 专利权人 | 中国科学院烟台海岸带研究所
|
| 申请日期 | 2022-08-15
|
| 2022-11-08
|
| 专利状态 | 授权
|
| 授权国家 | 中国
|
| 摘要 | 本发明涉及壳寡糖衍生物制备领域，具体涉及一种酚酸酯化N, N, N‑三甲基壳寡糖季铵盐及其制备方法和应用。酚酸酯化N, N, N‑三甲基壳寡糖季铵盐的结构式如下述式一所示，制备方法为：以壳寡糖为原料，首先对其2位氨基进行季铵化，得到N, N, N‑三甲基壳寡糖季铵盐，然后与酚酸反应，得到6位酯化的N, N, N‑三甲基壳寡糖季铵盐酚酸衍生物。本发明的优点是在壳寡糖的2位氨基和6位羟基同时引入了活性基团，测试表明，酚酸酯化N, N, N‑三甲基壳寡糖季铵盐具有很好的抗氧化活性。此外，衍生物制备过程易于操作，产率较高易于大规模产业化，有望广泛推广至食品、保健品、医药及日化等领域。式一。 |
| 其他摘要 | The invention relates to the field of preparation of chitosan oligosaccharide derivatives, in particular to a phenolic acid esterified N, N, N-trimethyl chitosan oligosaccharide quaternary ammonium salt as well as a preparation method and application of the phenolic acid esterified N, N, N-trimethyl chitosan oligosaccharide quaternary ammonium salt. The structural formula of N, N, N-trimethyl chitosan oligosaccharide quaternary ammonium salt esterified by phenolic acid is shown in formula I. The preparation method comprises the following steps of : firstly, quaternizing 2-amino of chitosan oligosaccharide serving as a raw material to obtain N, N, N-trimethyl chitosan oligosaccharide quaternary ammonium salt, and then reacting with phenolic acid to obtain 6-esterified N, N, N-trimethyl chitosan oligosaccharide quaternary ammonium salt phenolic acid derivative. The chitosan oligosaccharide quaternary ammonium salt has the advantages that active groups are introduced into the 2-position amino group and the 6-position hydroxyl group of the chitosan oligosaccharide at the same time, and tests show that the phenolic acid esterified N, N, N-trimethyl chitosan oligosaccharide quaternary ammonium salt has good antioxidant activity. In addition, the preparation process of the derivative is easy to operate, the yield is high, large-scale industrialization is facilitated, and the derivative is expected to be widely popularized to the fields of foods, health care products, medicines, daily chemicals and the like. Formula I. |
| 申请号 | 2022109711126
|
| 公开（公告）号 | CN115043958B
|
| IPC 分类号 | C08B37/08
; A23L33/125
; A23L3/3562
; A61P39/06
; A61P17/18
; C09K15/24
; A61K8/73
; A61Q19/08
; A61K8/60
; A61K31/7016
; A61K31/702
|
| 专利代理人 | 李颖
|
| 代理机构 | 沈阳科苑专利商标代理有限公司 21002
|
| CPC分类号 | C08B37/003
; A23L33/125
; A23L3/3562
; A61K31/722
; A61P39/06
; A61P17/18
; C09K15/24
; A61K8/736
; A61Q19/08
; A61K8/60
; A61K31/7016
; A61K31/702
; A23V2002/00
; A61K2800/522
|
| 文献类型 | 专利
|
| 条目标识符 | http://ir.yic.ac.cn/handle/133337/33550
|
| 专题 | 海岸带生物学与生物资源利用重点实验室_海岸带生物资源高效利用研究与发展中心
|
| 作者单位 | 中国科学院烟台海岸带研究所
|
推荐引用方式
GB/T 7714 |
郭占勇,孙艳,崔静敏. 一种酚酸酯化壳寡糖季铵盐及其制备方法和应用. 2022109711126[P]. 2022-11-08.
|
修改评论