Complex organization of the Streptomyces avermitilis genes encoding the avermectin polyketide synthase

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	Complex organization of the Streptomyces avermitilis genes encoding the avermectin polyketide synthase
	Douglas J. MacNeil ; James L. Occi ; Keith M. Gewain ; Tanya MacNeil ; Patrice H. Gibbons ; Carolyn L. Ruby and Susan J. Danis
发表期刊	Gene
ISSN	0378-1119
	1992
卷号	115 期号:1,2 页码:119-125
关键词	Erythromycin Macrolide Recombinant Dna Fermentation
英文摘要	The avermectin (Av) polyketide synthase (PKS) and erythromycin (Er) PKS are encoded by modular repeats of DNA, but the genetic organization of the modules encoding Av PKS is more complex than Er PKS. Sequencing of several related DNA fragments from Streptomyces avermitilis that are part of the Av biosynthetic gene cluster, revealed that they encode parts of large multifunctional PKS proteins. The Av PKS proteins show strong similarity to each other, as well as similarity to Er PKS proteins [Donadio et al., Science 252 (1991) 675–679] and fatty acid synthases. Partial DNA sequencing of the 65-kb region containing all the related sequence elements in the avr genes provides evidence for twelve modular repeats encoding FAS-like domains. The genes encoding the Av PKS are organized as two sets of six modular repeats which are convergently transcribed.
文献类型	期刊论文
条目标识符	http://ir.yic.ac.cn/handle/133337/3153
专题	科研共享资源
推荐引用方式 GB/T 7714	Douglas J. MacNeil,James L. Occi,Keith M. Gewain,et al. Complex organization of the Streptomyces avermitilis genes encoding the avermectin polyketide synthase[J]. Gene,1992,115(1,2):119-125.
APA	Douglas J. MacNeil,James L. Occi,Keith M. Gewain,Tanya MacNeil,Patrice H. Gibbons,&Carolyn L. Ruby and Susan J. Danis.(1992).Complex organization of the Streptomyces avermitilis genes encoding the avermectin polyketide synthase.Gene,115(1,2),119-125.
MLA	Douglas J. MacNeil,et al."Complex organization of the Streptomyces avermitilis genes encoding the avermectin polyketide synthase".Gene 115.1,2(1992):119-125.

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