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	Novel triazolyl-functionalized chitosan derivatives with different chain lengths of aliphatic alcohol substituent: Design, synthesis, and antifungal activity
	Li, Q; Tan, WQ; Zhang, CL; Gu, GD; Guo, ZY; Guo, ZY (reprint author), Chinese Acad Sci, Yantai Inst Coastal Zone Res, Key Lab Coastal Biol & Bioresource Utilizat, Yantai 264003, Peoples R China. [email protected]
发表期刊	CARBOHYDRATE RESEARCH
ISSN	0008-6215
	2015-12-11
卷号	418页码:44-49
关键词	Chitosan Derivatives Antifungal Activity 1 Aliphatic Alcohol 2 Chain Length 3-triazole
DOI	10.1016/j.carres.2015.10.005
产权排序	[Li, Qing; Tan, Wenqiang; Guo, Zhanyong] Chinese Acad Sci, Yantai Inst Coastal Zone Res, Key Lab Coastal Biol & Bioresource Utilizat, Yantai 264003, Peoples R China; [Tan, Wenqiang] Chinese Acad Sci, Grad Sch, Beijing 100039, Peoples R China; [Zhang, Caili] Yantai Univ, Sch Chem & Chem Engn, Yantai 264005, Peoples R China; [Gu, Guodong] Alliance Pharma Inc, Malvern, PA 19355 USA
作者部门	海岸带生物学与生物资源利用所重点实验室
英文摘要	Chemical modification of chitosan is increasingly studied for its potential of providing new application for chitosan. Here, we modify chitosan at its primary hydroxyl via 'click chemistry', and a group of novel water soluble chitosan derivatives with substituted 1,2,3-triazolyl group were designed and synthesized. Aliphatic alcohols with different lengths were used as functional dendrons to improve the antifungal activity of chitosan derivatives. Meanwhile, their antifungal activity against two kinds of phytopathogens was estimated by hypha measurement in vitro. All the chitosan derivatives exhibited excellent activity against tested fungi. It is found that the antifungal activity of chitosan derivatives against the tested fungi increases with augment in the chain length of straight aliphatic alcohols. And the hydrophobic moiety (alkyl) at the periphery of the synthesized chitosan derivatives tends to affect their antifungal activity. (C) 2015 Elsevier Ltd. All rights reserved.
文章类型	Article
资助机构	National Natural Science Foundation of China(41206152 ; Science and Technology Service Network Initiative(KFJ-EW-STS-060) ; Science and Technology Project of Weihai(2012GNS004) ; Taishan Scholar Program of Shandong Province ; 41576156)
收录类别	SCI
语种	英语
关键词[WOS]	FREE CLICK CHEMISTRY ; QUATERNIZED CHITOSAN ; ANTIBACTERIAL ACTIVITY ; ANTITUMOR-ACTIVITY ; MAILLARD REACTION ; MOLECULAR-WEIGHT ; IN-VITRO ; INHIBITORS ; 1,2,4-TRIAZOLES ; ANTIOXIDANT
研究领域[WOS]	Biochemistry & Molecular Biology ; Chemistry
WOS记录号	WOS:000366219900006
引用统计	被引频次：34[WOS]   [WOS记录]     [WOS相关记录]
文献类型	期刊论文
条目标识符	http://ir.yic.ac.cn/handle/133337/9316
专题	海岸带生物学与生物资源利用重点实验室_海岸带生物学与生物资源保护实验室 海岸带生物学与生物资源利用重点实验室_海岸带生物资源高效利用研究与发展中心
通讯作者	Guo, ZY (reprint author), Chinese Acad Sci, Yantai Inst Coastal Zone Res, Key Lab Coastal Biol & Bioresource Utilizat, Yantai 264003, Peoples R China. [email protected]
推荐引用方式 GB/T 7714	Li, Q,Tan, WQ,Zhang, CL,et al. Novel triazolyl-functionalized chitosan derivatives with different chain lengths of aliphatic alcohol substituent: Design, synthesis, and antifungal activity[J]. CARBOHYDRATE RESEARCH,2015,418:44-49.
APA	Li, Q,Tan, WQ,Zhang, CL,Gu, GD,Guo, ZY,&Guo, ZY .(2015).Novel triazolyl-functionalized chitosan derivatives with different chain lengths of aliphatic alcohol substituent: Design, synthesis, and antifungal activity.CARBOHYDRATE RESEARCH,418,44-49.
MLA	Li, Q,et al."Novel triazolyl-functionalized chitosan derivatives with different chain lengths of aliphatic alcohol substituent: Design, synthesis, and antifungal activity".CARBOHYDRATE RESEARCH 418(2015):44-49.

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Novel triazolyl-func（711KB）	期刊论文	作者接受稿	开放获取	CC BY-NC-SA	浏览 请求全文

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