Institutional Repository of Key Laboratory of Coastal Zone Environmental Processes, Yantai Institute of Coastal Zone Research, Chinese Academy of Sciences (KLCEP)
| A dual response near-infrared fluorescent probe for hydrogen polysulfides and superoxide anion detection in cells and in vivo | |
Yu, FB; Gao, M ; Li, M; Chen, LX; Chen, LX (reprint author), Chinese Acad Sci, Key Lab Coastal Environm Proc & Ecol Remediat, Res Ctr Coastal Environm Engn & Technol, Yantai Inst Coastal Zone Res, Yantai 264003, Peoples R China. [email protected]
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| 发表期刊 | BIOMATERIALS
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| ISSN | 0142-9612 |
| 2015-09-01 | |
| 卷号 | 63页码:93-101 |
| 关键词 | Fluorescent Probe Image Analysis Hydrogen Polysulfides Superoxide Anion Near-infrared |
| DOI | 10.1016/j.biomaterials.2015.06.007 |
| 产权排序 | [Yu, Fabiao; Gao, Min; Li, Meng; Chen, Lingxin] Chinese Acad Sci, Key Lab Coastal Environm Proc & Ecol Remediat, Res Ctr Coastal Environm Engn & Technol, Yantai Inst Coastal Zone Res, Yantai 264003, Peoples R China |
| 作者部门 | 中科院海岸带环境过程与生态修复重点实验室 |
| 英文摘要 | Intracellular reactive sulfur species play important roles in physiological and pathological processes. Emerging evidences suggest that sulfane sulfur instead of H2S is the actual signaling molecule in these processes. Sulfane sulfur can be generated as a result of the reaction between O-2 and H2S in mitochondria. Therefore, we develop a near-infrared mitochondria-targeting probe that allows multiresponse to O-2 and H2SO successively for investigating this biosynthetic reaction. The probe exhibits highly selective fluorescent response to O-2 and H2SO successively in presence of potential biological interferants. Fluorescent imaging studies and flow cytometry analysis of RAW264.7 cells elaborate that the probe can be used to reveal the continuous process of O-2 burst and H2SO production in situ and in real-time. The mitochondria isolation indicates that the probe can specifically localize in mitochondria. Finally, the fluorescent probe has been successfully applied to detect O-2 and H2Sn in mice. (C) 2015 Elsevier Ltd. All rights reserved. |
| 文章类型 | Article |
| 收录类别 | SCI |
| 语种 | 英语 |
| 关键词[WOS] | DIFFERENT EMISSION CHANNELS ; REACTIVE OXYGEN ; LIVING CELLS ; OXIDATIVE STRESS ; LIVE CELLS ; HYPOCHLOROUS ACID ; SULFANE SULFUR ; SULFIDE ; PEROXYNITRITE ; H2S |
| 研究领域[WOS] | Engineering ; Materials Science |
| WOS记录号 | WOS:000357910400009 |
| 引用统计 | |
| 文献类型 | 期刊论文 |
| 条目标识符 | http://ir.yic.ac.cn/handle/133337/9271 |
| 专题 | 中国科学院海岸带环境过程与生态修复重点实验室 |
| 通讯作者 | Chen, LX (reprint author), Chinese Acad Sci, Key Lab Coastal Environm Proc & Ecol Remediat, Res Ctr Coastal Environm Engn & Technol, Yantai Inst Coastal Zone Res, Yantai 264003, Peoples R China. [email protected] |
| 推荐引用方式 GB/T 7714 | Yu, FB,Gao, M,Li, M,et al. A dual response near-infrared fluorescent probe for hydrogen polysulfides and superoxide anion detection in cells and in vivo[J]. BIOMATERIALS,2015,63:93-101. |
| APA | Yu, FB,Gao, M,Li, M,Chen, LX,&Chen, LX .(2015).A dual response near-infrared fluorescent probe for hydrogen polysulfides and superoxide anion detection in cells and in vivo.BIOMATERIALS,63,93-101. |
| MLA | Yu, FB,et al."A dual response near-infrared fluorescent probe for hydrogen polysulfides and superoxide anion detection in cells and in vivo".BIOMATERIALS 63(2015):93-101. |
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