"Off-On" based fluorescent chemosensor for Cu2+ in aqueous media and living cells

	"Off-On" based fluorescent chemosensor for Cu2+ in aqueous media and living cells
	Yu, Chunwei 1,4; Chen, Lingxin1 ; Zhang, Jun 3; Li, Jinhua1 ; Liu, Ping 1; Wang, Wenhai1 ; Yan, Bing 2
发表期刊	TALANTA
	2011-09-15
卷号	85 期号:3 页码:1627-1633
关键词	Cu2++ Fluorescent Chemosensor Rhodamine b Fluorescence Imaging Living Cells
英文摘要	A novel Cu2+-specific "off-on" fluorescent chemosensor of naphthalimide modified rhodamine B (naphthalimide modified rhodamine B chemosensor, NRC) was designed and synthesized, based on the equilibrium between the spirolactam (non-fluorescence) and the ring-opened amide (fluorescence). The chemosensor NRC showed high Cu2+-selective fluorescence enhancement over commonly coexistent metal ions or anions in neutral aqueous media. The limit of detection (LOD) based on 3 x delta(blank)/k was obtained as low as 0.18 mu M of Cu2+, as well as an excellent linearity of 0.05-4.5 mu M (R=0.999), indicating the chemosensor of high sensitivity and wide quantitation range. And also the coordination mode with 1:1 stoichiometry was proposed between NRC and Cu2+. In addition, the effects of pH, co-existing metal ions and anions, and the reversibility were investigated in detail. It was also demonstrated that the NRC could be used as an excellent "off-on" fluorescent chemosensor for the measurement of Cu2+ in living cells with satisfying results, which further displayed its valuable applications in biological systems. (C) 2011 Elsevier B.V. All rights reserved.
文章类型	Article
收录类别	SCI
语种	英语
关键词[WOS]	SELECTIVE DETECTION ; LIVE-CELL ; SENSOR ; PROBES ; COPPER ; CU(II) ; WATER ; ION ; CHEMODOSIMETER ; FLUOROPHORE
研究领域[WOS]	Chemistry
WOS记录号	WOS:000294092800059
引用统计	被引频次：116[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	http://ir.yic.ac.cn/handle/133337/9246
专题	中国科学院海岸带环境过程与生态修复重点实验室
作者单位	1.Chinese Acad Sci, Key Lab Coastal Zone Environm Proc, Shandong Prov Key Lab Coastal Zone Environm Proc, Yantai Inst Coastal Zone Res, Yantai 264003, Peoples R China 2.Shandong Univ, Sch Chem & Chem Engn, Jinan 250100, Peoples R China 3.Hainan Med Univ, Sch Trop & Lab Med, Haikou 571101, Peoples R China 4.Chinese Acad Sci, Grad Univ, Beijing 100049, Peoples R China
推荐引用方式 GB/T 7714	Yu, Chunwei,Chen, Lingxin,Zhang, Jun,et al. "Off-On" based fluorescent chemosensor for Cu2+ in aqueous media and living cells[J]. TALANTA,2011,85(3):1627-1633.
APA	Yu, Chunwei.,Chen, Lingxin.,Zhang, Jun.,Li, Jinhua.,Liu, Ping.,...&Yan, Bing.(2011)."Off-On" based fluorescent chemosensor for Cu2+ in aqueous media and living cells.TALANTA,85(3),1627-1633.
MLA	Yu, Chunwei,et al.""Off-On" based fluorescent chemosensor for Cu2+ in aqueous media and living cells".TALANTA 85.3(2011):1627-1633.

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