pHe-Induced Charge-Reversible NIR Fluorescence Nanoprobe for Tumor-Specific Imaging

YIC-IR > 中国科学院海岸带环境过程与生态修复重点实验室 > 海岸带环境工程技术研究与发展中心

	pHe-Induced Charge-Reversible NIR Fluorescence Nanoprobe for Tumor-Specific Imaging
	Dong, Chunhong 1; Liu, Zhongyun 3; Zhang, Lei 1,2; Guo, Weisheng 1; Li, Xue 1; Liu, Junqing 1; Wang, Hanjie 1,4; Chang, Jin 1,4
发表期刊	ACS APPLIED MATERIALS & INTERFACES
	2015-04-15
卷号	7 期号:14 页码:7566-7575
关键词	Qds Nanoprobe Tumor Extracellular Ph Ph-sensitive Charge Reversion Tumor Specific Imaging
英文摘要	Inspired by the specificity of acid tumor microenvironment, we constructed a flexible charge-reversible near-infrared (NIR) fluorescence nanoprobe in response to tumor extracellular pH (pHe) for effective tumor-specific imaging. The nanoprobe consists of an NIR-emitted CuInS2/ZnS quantum dot (CIS/ZS QDs) core and a tailored lauric acid and 2,3-dimethylmaleic anhydride modified e-polylysine (epsilon-PL-g-LA/DMA) shell, which provides not only a dense protective layer for the QDs but also the ability of pHe-induced positive charge-mediated endocytosis into tumor cells. The results showed that the QDs@epsilon-PL-g-LA/DMA nanoprobe with a uniform size of 40 nm had high chemical stability at pH 7.4 and excellent optical properties. Especially, it swiftly reversed its surface charge to positive in 20 min when exposed to pHe due to the cleavage of the beta-carboxyl amide bond of epsilon-PL-g-LA/DMA. Moreover, the cell uptake of the pHe-sensitive QDs nanoprobe exposed at pH 6.8 into HeLa cells is much more significant than that at pH 7.4, which further verified the availability of the electrostatic adsorptive endocytosis facilitated targeting ability. The pHe-induced targeting imparted the QDs nanoprobe a broad targeting ability in a variety of solid tumors. Furthermore, as an effective alternative mechanism for tumor targeting, responsive charge reversion is also universally applicable to other cancer theranostics agent.
文章类型	Article
收录类别	SCI
语种	英语
关键词[WOS]	TARGETED DRUG-DELIVERY ; QUANTUM DOTS ; IN-VIVO ; HIGHLY LUMINESCENT ; SURFACE-CHARGE ; NANOPARTICLES ; MICROENVIRONMENT ; NANOCARRIERS ; INTERNALIZATION ; NANOCRYSTALS
研究领域[WOS]	Science & Technology - Other Topics ; Materials Science
WOS记录号	WOS:000353177000018
引用统计	被引频次：23[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	http://ir.yic.ac.cn/handle/133337/9084
专题	中国科学院海岸带环境过程与生态修复重点实验室_海岸带环境工程技术研究与发展中心
作者单位	1.Tianjin Univ, Sch Life Sci, Sch Mat Sci & Engn, Tianjin 300072, Peoples R China 2.Tianjin Univ, Sch Environm Sci & Engn, Tianjin 300072, Peoples R China 3.Chinese Acad Sci, Yantai Inst Coastal Zone Res, Yantai 264003, Shandong, Peoples R China 4.Collaborat Innovat Ctr Chem Sci & Engn Tianjin, Tianjin 300072, Peoples R China
推荐引用方式 GB/T 7714	Dong, Chunhong,Liu, Zhongyun,Zhang, Lei,et al. pHe-Induced Charge-Reversible NIR Fluorescence Nanoprobe for Tumor-Specific Imaging[J]. ACS APPLIED MATERIALS & INTERFACES,2015,7(14):7566-7575.
APA	Dong, Chunhong.,Liu, Zhongyun.,Zhang, Lei.,Guo, Weisheng.,Li, Xue.,...&Chang, Jin.(2015).pHe-Induced Charge-Reversible NIR Fluorescence Nanoprobe for Tumor-Specific Imaging.ACS APPLIED MATERIALS & INTERFACES,7(14),7566-7575.
MLA	Dong, Chunhong,et al."pHe-Induced Charge-Reversible NIR Fluorescence Nanoprobe for Tumor-Specific Imaging".ACS APPLIED MATERIALS & INTERFACES 7.14(2015):7566-7575.