Institutional Repository of Key Laboratory of Coastal Zone Environmental Processes, Yantai Institute of Coastal Zone Research, Chinese Academy of Sciences (KLCEP)
| Near-Infrared Fluorescent Probe for Imaging Mitochondrial Hydrogen Polysulfides in Living Cells and in Vivo | |
Gao, Min1,2; Yu, Fabiao1; Chen, Hao1; Chen, Lingxin1,2 ; Chen, LX (reprint author), Chinese Acad Sci, Key Lab Coastal Environm Proc & Ecol Remediat, Res Ctr Coastal Environm Engn & Technol, Yantai Inst Coastal Zone Res, Yantai 264003, Peoples R China. [email protected]
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| 发表期刊 | ANALYTICAL CHEMISTRY
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| ISSN | 0003-2700 |
| 2015-04-07 | |
| 卷号 | 87期号:7页码:3631-3638 |
| 关键词 | Sulfane Sulfur Hypochlorous Acid Reactive Oxygen Sulfide Biology H2s Cysteine Chemistry Design Thiols |
| DOI | 10.1021/ac5044237 |
| 产权排序 | [Gao, Min; Yu, Fabiao; Chen, Hao; Chen, Lingxin] Chinese Acad Sci, Key Lab Coastal Environm Proc & Ecol Remediat, Res Ctr Coastal Environm Engn & Technol, Yantai Inst Coastal Zone Res, Yantai 264003, Peoples R China; [Gao, Min; Chen, Lingxin] Qufu Normal Univ, Key Lab Life Organ Anal, Coll Chem & Chem Engn, Qufu 273165, Peoples R China |
| 作者部门 | 中科院海岸带环境过程与生态修复重点实验室 |
| 英文摘要 | Hydrogen polysulfides (H2Sn, n > 1), derived from hydrogen sulfide (H2S), have attracted increasing attention in biochemical research, which may perform as the actual signaling molecules during cell signaling processes. Because of the closed biological and chemical relationship between H2S and H2Sn, it is of great value to develop sensitive and specific techniques to distinguish the intracellular level of H2Sn. To improve the understanding of the physiological and pathological roles played by H2Sn, we now develop a specific fluorescent probe Mito-ss for capturing H2Sn in cells and in vivo. When triggered by H2Sn, Mito-ss replies a turn-on fluorescence signal and exhibits a higher selectivity toward H2Sn than other abundant competing biothiols, such as glutathione, cysteine and H2S. The probe Mito-ss can also be applied to visual H2Sn in living cells, as well as in vivo, providing a potentially powerful approach for probing H2Sn in biological systems.; Hydrogen polysulfides (H2Sn, n > 1), derived from hydrogen sulfide (H2S), have attracted increasing attention in biochemical research, which may perform as the actual signaling molecules during cell signaling processes. Because of the closed biological and chemical relationship between H2S and H2Sn, it is of great value to develop sensitive and specific techniques to distinguish the intracellular level of H2Sn. To improve the understanding of the physiological and pathological roles played by H2Sn, we now develop a specific fluorescent probe Mito-ss for capturing H2Sn in cells and in vivo. When triggered by H2Sn, Mito-ss replies a turn-on fluorescence signal and exhibits a higher selectivity toward H2Sn than other abundant competing biothiols, such as glutathione, cysteine and H2S. The probe Mito-ss can also be applied to visual H2Sn in living cells, as well as in vivo, providing a potentially powerful approach for probing H2Sn in biological systems. |
| 文章类型 | Article |
| 资助机构 | Chemistry |
| 收录类别 | SCI |
| 语种 | 英语 |
| 关键词[WOS] | SULFANE SULFUR ; HYPOCHLOROUS ACID ; REACTIVE OXYGEN ; SULFIDE ; BIOLOGY ; H2S ; CYSTEINE ; CHEMISTRY ; DESIGN ; THIOLS |
| 研究领域[WOS] | Chemistry |
| WOS记录号 | WOS:000352659500013 |
| 引用统计 | |
| 文献类型 | 期刊论文 |
| 条目标识符 | http://ir.yic.ac.cn/handle/133337/8632 |
| 专题 | 中国科学院海岸带环境过程与生态修复重点实验室 |
| 通讯作者 | Chen, LX (reprint author), Chinese Acad Sci, Key Lab Coastal Environm Proc & Ecol Remediat, Res Ctr Coastal Environm Engn & Technol, Yantai Inst Coastal Zone Res, Yantai 264003, Peoples R China. [email protected] |
| 作者单位 | 1.Chinese Acad Sci, Key Lab Coastal Environm Proc & Ecol Remediat, Res Ctr Coastal Environm Engn & Technol, Yantai Inst Coastal Zone Res, Yantai 264003, Peoples R China 2.Qufu Normal Univ, Key Lab Life Organ Anal, Coll Chem & Chem Engn, Qufu 273165, Peoples R China |
| 推荐引用方式 GB/T 7714 | Gao, Min,Yu, Fabiao,Chen, Hao,et al. Near-Infrared Fluorescent Probe for Imaging Mitochondrial Hydrogen Polysulfides in Living Cells and in Vivo[J]. ANALYTICAL CHEMISTRY,2015,87(7):3631-3638. |
| APA | Gao, Min,Yu, Fabiao,Chen, Hao,Chen, Lingxin,&Chen, LX .(2015).Near-Infrared Fluorescent Probe for Imaging Mitochondrial Hydrogen Polysulfides in Living Cells and in Vivo.ANALYTICAL CHEMISTRY,87(7),3631-3638. |
| MLA | Gao, Min,et al."Near-Infrared Fluorescent Probe for Imaging Mitochondrial Hydrogen Polysulfides in Living Cells and in Vivo".ANALYTICAL CHEMISTRY 87.7(2015):3631-3638. |
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