Institutional Repository of Key Laboratory of Coastal Zone Environmental Processes, Yantai Institute of Coastal Zone Research, Chinese Academy of Sciences (KLCEP)
| The relations between metabolic variations and genetic evolution of different species | |
Li, Zhishui1; Lin, Chenghong1; Xu, Jingjing1; Wu, Huifeng2 ; Feng, Jianghua1; Huang, Heguang3; Feng, JH (reprint author), Xiamen Univ, Fujian Prov Key Lab Plasma & Magnet Resonance, Dept Elect Sci, Xiamen 361005, Peoples R China. [email protected]
| |
| 发表期刊 | ANALYTICAL BIOCHEMISTRY
 |
| ISSN | 0003-2697 |
| 2015-05-15 | |
| 卷号 | 477页码:105-114 |
| 关键词 | Nmr Metabonomics Physiological Variation Laboratory Animals Genetic Evolution |
| DOI | 10.1016/j.ab.2015.02.024 |
| 产权排序 | [Li, Zhishui; Lin, Chenghong; Xu, Jingjing; Feng, Jianghua] Xiamen Univ, Fujian Prov Key Lab Plasma & Magnet Resonance, Dept Elect Sci, Xiamen 361005, Peoples R China; [Wu, Huifeng] Chinese Acad Sci, Yantai Inst Coastal Zone Res, Shandong Prov Key Lab Coastal Zone Environm Proc, Key Lab Coastal Zone Environm Proc, Yantai 264003, Peoples R China; [Huang, Heguang] Fujian Med Univ, Union Hosp, Basic Surg Dept, Fuzhou 350001, Peoples R China |
| 作者部门 | 中科院海岸带环境过程与生态修复重点实验室 |
| 英文摘要 | Metabonomics has been applied in many bio-related scientific fields. Nevertheless, some animal research works are shown to fail when they are extended to humans. Therefore, it is essential to figure out suitable animal modeling to mimic human metabolism so that animal findings can serve humans. In this study, two kinds of commonly selected body fluids, serum and urine, from humans and various experimental animals were characterized by integration of nuclear magnetic resonance (NMR) spectroscopy with multivariate statistical analysis to identify the interspecies metabolic differences and similarities at a baseline physiological status. Our results highlight that the dairy cow and pig may be an optimal choice for transportation and biodistribution studies of drugs and that the Kunming (KM) mouse model may be the most effective for excretion studies of drugs, whereas the Sprague-Dawley (SD) rat could be the most suitable candidate for animal modeling under overall considerations. The biochemical pathways analyses further provide an interconnection between genetic evolution and metabolic variations, where species evolution most strongly affects microbial biodiversity and, consequently, has effects on the species-specific biological substances of biosynthesis and corresponding biological activities. Knowledge of the metabolic effects from species difference will enable the construction of better models for disease diagnosis, drug metabolism, and toxicology research. (C) 2015 Elsevier Inc. All rights reserved.; Metabonomics has been applied in many bio-related scientific fields. Nevertheless, some animal research works are shown to fail when they are extended to humans. Therefore, it is essential to figure out suitable animal modeling to mimic human metabolism so that animal findings can serve humans. In this study, two kinds of commonly selected body fluids, serum and urine, from humans and various experimental animals were characterized by integration of nuclear magnetic resonance (NMR) spectroscopy with multivariate statistical analysis to identify the interspecies metabolic differences and similarities at a baseline physiological status. Our results highlight that the dairy cow and pig may be an optimal choice for transportation and biodistribution studies of drugs and that the Kunming (KM) mouse model may be the most effective for excretion studies of drugs, whereas the Sprague-Dawley (SD) rat could be the most suitable candidate for animal modeling under overall considerations. The biochemical pathways analyses further provide an interconnection between genetic evolution and metabolic variations, where species evolution most strongly affects microbial biodiversity and, consequently, has effects on the species-specific biological substances of biosynthesis and corresponding biological activities. Knowledge of the metabolic effects from species difference will enable the construction of better models for disease diagnosis, drug metabolism, and toxicology research. (C) 2015 Elsevier Inc. All rights reserved. |
| 文章类型 | Article |
| 资助机构 | Biochemistry & Molecular Biology ; Chemistry |
| 收录类别 | SCI |
| 语种 | 英语 |
| 关键词[WOS] | H-1-NMR SPECTROSCOPY ; IDENTIFICATION ; RAT ; NMR ; METABONOMICS ; INFORMATION ; ANIMALS ; DISEASE ; MOUSE ; MODEL |
| 研究领域[WOS] | Biochemistry & Molecular Biology ; Chemistry |
| WOS记录号 | WOS:000353609400020 |
| 引用统计 | |
| 文献类型 | 期刊论文 |
| 条目标识符 | http://ir.yic.ac.cn/handle/133337/8620 |
| 专题 | 中国科学院海岸带环境过程与生态修复重点实验室 |
| 通讯作者 | Feng, JH (reprint author), Xiamen Univ, Fujian Prov Key Lab Plasma & Magnet Resonance, Dept Elect Sci, Xiamen 361005, Peoples R China. [email protected] |
| 作者单位 | 1.Xiamen Univ, Fujian Prov Key Lab Plasma & Magnet Resonance, Dept Elect Sci, Xiamen 361005, Peoples R China 2.Chinese Acad Sci, Yantai Inst Coastal Zone Res, Shandong Prov Key Lab Coastal Zone Environm Proc, Key Lab Coastal Zone Environm Proc, Yantai 264003, Peoples R China 3.Fujian Med Univ, Union Hosp, Basic Surg Dept, Fuzhou 350001, Peoples R China |
| 推荐引用方式 GB/T 7714 | Li, Zhishui,Lin, Chenghong,Xu, Jingjing,et al. The relations between metabolic variations and genetic evolution of different species[J]. ANALYTICAL BIOCHEMISTRY,2015,477:105-114. |
| APA | Li, Zhishui.,Lin, Chenghong.,Xu, Jingjing.,Wu, Huifeng.,Feng, Jianghua.,...&Feng, JH .(2015).The relations between metabolic variations and genetic evolution of different species.ANALYTICAL BIOCHEMISTRY,477,105-114. |
| MLA | Li, Zhishui,et al."The relations between metabolic variations and genetic evolution of different species".ANALYTICAL BIOCHEMISTRY 477(2015):105-114. |
| 条目包含的文件 | 下载所有文件 | |||||
| 文件名称/大小 | 文献类型 | 版本类型 | 开放类型 | 使用许可 | ||
| The relations betwee（1113KB） | 开放获取 | CC BY-NC-SA | 浏览 下载 | |||
除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。
修改评论