| Synthesis of amphiphilic aminated inulin via 'click chemistry' and evaluation for its antibacterial activity | |
Dong, Fang1 ; Zhang, Jun2; Yu, Chunwei2; Li, Qing1; Ren, Jianming1; Wang, Gang1; Gu, Guodong3; Guo, Zhanyong1; Guo, ZY (reprint author), Chinese Acad Sci, Yantai Inst Coastal Zone Res, Key Lab Coastal Biol & Bioresource Utilizat, Yantai 264003, Peoples R China. [email protected]
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| 发表期刊 | BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
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| ISSN | 0960-894X |
| 2014-09-15 | |
| 卷号 | 24期号:18页码:4590-4593 |
| 关键词 | Inulin Click Chemistry Selective Modification Reactive Precursor Antibacterial Activity |
| DOI | 10.1016/j.bmcl.2014.07.029 |
| 产权排序 | [Dong, Fang; Li, Qing; Ren, Jianming; Wang, Gang; Guo, Zhanyong] Chinese Acad Sci, Yantai Inst Coastal Zone Res, Key Lab Coastal Biol & Bioresource Utilizat, Yantai 264003, Peoples R China; [Zhang, Jun; Yu, Chunwei] Hainan Med Coll, Sch Trop & Lab Med, Environm Monitoring Lab, Haikou 571199, Peoples R China; [Gu, Guodong] Alliance Pharma Inc, Malvern, PA 19355 USA |
| 作者部门 | 海岸带生物学与生物资源利用所重点实验室 |
| 英文摘要 | Inulins are a group of abundant, water-soluble, renewable polysaccharides, which exhibit attractive bioactivities and natural properties. Improvement such as chemical modification of inulin is often performed prior to further utilization. We hereby presented a method to modify inulin at its primary hydroxyls to synthesize amphiphilic aminated inulin via 'click chemistry' to facilitate its chemical manipulation. Additionally, its antibacterial property against Staphylococcus aureus (S. aureus) was also evaluated and the best inhibitory index against S. aureus was 58% at 1 mg/mL. As the amphiphilic aminated inulin is easy to prepare and exhibits improved bioactivity, this material may represent as an attractive new platform for chemical modifications of inulin. (C) 2014 Elsevier Ltd. All rights reserved. |
| 文章类型 | Article |
| 资助机构 | 12th Five-Year Science and Technology Plan for Agriculture 2012BAD32B09 ; Science and Technology Project of Yantai 20121321 ; Chemistry ; Taishan Scholar Program of Shandong Province |
| 收录类别 | SCI |
| 语种 | 英语 |
| 关键词[WOS] | CHITOSAN DERIVATIVES |
| 研究领域[WOS] | Pharmacology & Pharmacy ; Chemistry |
| WOS记录号 | WOS:000341435000046 |
| 引用统计 | |
| 文献类型 | 期刊论文 |
| 条目标识符 | http://ir.yic.ac.cn/handle/133337/8530 |
| 专题 | 海岸带生物学与生物资源利用重点实验室_海岸带生物学与生物资源保护实验室 中国科学院海岸带环境过程与生态修复重点实验室_污染过程与控制实验室 |
| 通讯作者 | Guo, ZY (reprint author), Chinese Acad Sci, Yantai Inst Coastal Zone Res, Key Lab Coastal Biol & Bioresource Utilizat, Yantai 264003, Peoples R China. [email protected] |
| 作者单位 | 1.Chinese Acad Sci, Yantai Inst Coastal Zone Res, Key Lab Coastal Biol & Bioresource Utilizat, Yantai 264003, Peoples R China 2.Hainan Med Coll, Sch Trop & Lab Med, Environm Monitoring Lab, Haikou 571199, Peoples R China 3.Alliance Pharma Inc, Malvern, PA 19355 USA |
| 推荐引用方式 GB/T 7714 | Dong, Fang,Zhang, Jun,Yu, Chunwei,et al. Synthesis of amphiphilic aminated inulin via 'click chemistry' and evaluation for its antibacterial activity[J]. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS,2014,24(18):4590-4593. |
| APA | Dong, Fang.,Zhang, Jun.,Yu, Chunwei.,Li, Qing.,Ren, Jianming.,...&Guo, ZY .(2014).Synthesis of amphiphilic aminated inulin via 'click chemistry' and evaluation for its antibacterial activity.BIOORGANIC & MEDICINAL CHEMISTRY LETTERS,24(18),4590-4593. |
| MLA | Dong, Fang,et al."Synthesis of amphiphilic aminated inulin via 'click chemistry' and evaluation for its antibacterial activity".BIOORGANIC & MEDICINAL CHEMISTRY LETTERS 24.18(2014):4590-4593. |
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| Synthesis of amphiph（697KB） | 期刊论文 | 出版稿 | 开放获取 | CC BY-NC-SA | 浏览 请求全文 | |
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