Institutional Repository of Key Laboratory of Coastal Zone Environmental Processes, Yantai Institute of Coastal Zone Research, Chinese Academy of Sciences (KLCEP)
| Graphene Oxide Wrapped SERS Tags: Multifunctional Platforms toward Optical Labeling, Photothermal Ablation of Bacteria, and the Monitoring of Killing Effect | |
Lin, Donghai1; Qin, Tianqi1; Wang, Yunqing2 ; Sun, Xiuyan1; Chen, Lingxin2
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| 发表期刊 | ACS APPLIED MATERIALS & INTERFACES
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| ISSN | 1944-8244 |
| 2014-01-22 | |
| 卷号 | 6期号:2页码:1320-1329 |
| 关键词 | Graphene Oxide Gold Nanoparticles Sers Tags Bacteria Photothermal Ablation |
| 产权排序 | [Lin, Donghai; Qin, Tianqi; Sun, Xiuyan] Yantai Univ, Sch Pharm, Yantai 264005, Peoples R China; [Wang, Yunqing; Chen, Lingxin] Chinese Acad Sci, Yantai Inst Coastal Zone Res, Key Lab Coastal Environm Proc & Ecol Remediat, Yantai 264003, Peoples R China |
| 通讯作者 | Wang, YQ (reprint author), Chinese Acad Sci, Yantai Inst Coastal Zone Res, Key Lab Coastal Environm Proc & Ecol Remediat, Yantai 264003, Peoples R China. [email protected] ; [email protected] |
| 英文摘要 | As novel optical nanoprobes, surface-enhanced Raman scattering (SERS) tags have drawn growing interests in the application of biomedical imaging and phototherapies. Herein, we demonstrated a novel in situ synthesis strategy for GO wrapped gold nanocluster SERS tags by using a tris(2,2'-bipyridyl)ruthenium-(II) chloride (Rubpy)/GO nanohybrid as a complex Raman reporter, inspired by the role of GO as an artificial receptor for various dyes. The introduction of GO in the synthesis procedure provided systematic solutions for controlling several key parameters of SERS tags, including reproducibility, sensitivity, and colloidal and signal stability. An additional interesting thermal-sensitive SERS property (SERS intensity decreased upon increasing the temperature) was also achieved due to the heat-induced release/redistribution of reporter molecules adsorbed on GO. Combining the synergic effect of these features, we further fabricated multifunctional, aldehyde group conjugated Au@Rubpy/GO SEAS tags for optical labeling and photothermal ablation of bacteria. Sensitive Raman imaging of gram-positive (Staphylococcus aureus) and gram-negative (Escherichia coli) bacteria could be realized, and satisfactory photothermal killing efficacy for both bacteria was achieved. Our results also demonstrated the correlation among the SEAS intensity decrease ratio, bacteria survival rate, and the terminal temperature of the tag-bacteria suspension, showing the possibility to use SERS assay to measure antibacterial response during the photothermal process using this tag.; As novel optical nanoprobes, surface-enhanced Raman scattering (SERS) tags have drawn growing interests in the application of biomedical imaging and phototherapies. Herein, we demonstrated a novel in situ synthesis strategy for GO wrapped gold nanocluster SERS tags by using a tris(2,2'-bipyridyl)ruthenium-(II) chloride (Rubpy)/GO nanohybrid as a complex Raman reporter, inspired by the role of GO as an artificial receptor for various dyes. The introduction of GO in the synthesis procedure provided systematic solutions for controlling several key parameters of SERS tags, including reproducibility, sensitivity, and colloidal and signal stability. An additional interesting thermal-sensitive SERS property (SERS intensity decreased upon increasing the temperature) was also achieved due to the heat-induced release/redistribution of reporter molecules adsorbed on GO. Combining the synergic effect of these features, we further fabricated multifunctional, aldehyde group conjugated Au@Rubpy/GO SEAS tags for optical labeling and photothermal ablation of bacteria. Sensitive Raman imaging of gram-positive (Staphylococcus aureus) and gram-negative (Escherichia coli) bacteria could be realized, and satisfactory photothermal killing efficacy for both bacteria was achieved. Our results also demonstrated the correlation among the SEAS intensity decrease ratio, bacteria survival rate, and the terminal temperature of the tag-bacteria suspension, showing the possibility to use SERS assay to measure antibacterial response during the photothermal process using this tag. |
| 文章类型 | Article |
| 资助机构 | National Natural Science Foundation of China [81102415, 21275158]; Natural Science Foundation of Shandong Province of China [ZR2010BQ012]; Science and Technology Development Plan of Yantai [2011071]; One Hundred Person Project of the Chinese Academy of Sciences |
| 收录类别 | SCI |
| 语种 | 英语 |
| 关键词[WOS] | ENHANCED RAMAN-SCATTERING ; FUNCTIONALIZED SILVER NANOPARTICLES ; SHELL NANOPARTICLES ; GOLD NANOPARTICLES ; DRUG-DELIVERY ; SURFACE ; SPECTROSCOPY ; THERAPY ; ANTIAGGREGATION ; FABRICATION |
| 研究领域[WOS] | Science & Technology - Other Topics ; Materials Science |
| WOS记录号 | WOS:000330201900080 |
| 引用统计 | |
| 文献类型 | 期刊论文 |
| 条目标识符 | http://ir.yic.ac.cn/handle/133337/6909 |
| 专题 | 中国科学院海岸带环境过程与生态修复重点实验室 |
| 作者单位 | 1.Yantai Univ, Sch Pharm, Yantai 264005, Peoples R China 2.Chinese Acad Sci, Yantai Inst Coastal Zone Res, Key Lab Coastal Environm Proc & Ecol Remediat, Yantai 264003, Peoples R China |
| 推荐引用方式 GB/T 7714 | Lin, Donghai,Qin, Tianqi,Wang, Yunqing,et al. Graphene Oxide Wrapped SERS Tags: Multifunctional Platforms toward Optical Labeling, Photothermal Ablation of Bacteria, and the Monitoring of Killing Effect[J]. ACS APPLIED MATERIALS & INTERFACES,2014,6(2):1320-1329. |
| APA | Lin, Donghai,Qin, Tianqi,Wang, Yunqing,Sun, Xiuyan,&Chen, Lingxin.(2014).Graphene Oxide Wrapped SERS Tags: Multifunctional Platforms toward Optical Labeling, Photothermal Ablation of Bacteria, and the Monitoring of Killing Effect.ACS APPLIED MATERIALS & INTERFACES,6(2),1320-1329. |
| MLA | Lin, Donghai,et al."Graphene Oxide Wrapped SERS Tags: Multifunctional Platforms toward Optical Labeling, Photothermal Ablation of Bacteria, and the Monitoring of Killing Effect".ACS APPLIED MATERIALS & INTERFACES 6.2(2014):1320-1329. |
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