| Secondary Metabolites from Penicillium pinophilum SD-272, a Marine Sediment-Derived Fungus | |
Wang, Ming-Hui1,2; Li, Xiao-Ming1; Li, Chun-Shun1; Ji, Nai-Yun3 ; Wang, Bin-Gui1
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| 发表期刊 | MARINE DRUGS
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| 2013-06-01 | |
| 卷号 | 11期号:6页码:2230-2238 |
| 关键词 | Sediment Penicillium Pinophilum Secondary Metabolite Brine Shrimp Lethality |
| 产权排序 | [Wang, Ming-Hui; Li, Xiao-Ming; Li, Chun-Shun; Wang, Bin-Gui] Chinese Acad Sci, Inst Oceanol, Key Lab Expt Marine Biol, Qingdao 266071, Peoples R China; [Wang, Ming-Hui] Univ Chinese Acad Sci, Beijing 100049, Peoples R China; [Ji, Nai-Yun] Chinese Acad Sci, Yantai Inst Coastal Zone Res, Key Lab Coastal Biol & Bioresource Utilizat, Yantai 264003, Peoples R China |
| 通讯作者 | Ji, NY (reprint author), Chinese Acad Sci, Yantai Inst Coastal Zone Res, Key Lab Coastal Biol & Bioresource Utilizat, Chunhui Rd 17, Yantai 264003, Peoples R China. [email protected] |
| 英文摘要 | Two new secondary metabolites, namely, pinodiketopiperazine A (1) and 6,7-dihydroxy-3-methoxy-3-methylphthalide (2), along with alternariol 2,4-dimethyl ether (3) and L-5-oxoproline methyl ester (4), which were isolated from a natural source for the first time but have been previously synthesized, were characterized from the marine sediment-derived fungus Penicillium pinophilum SD-272. In addition, six known metabolites (5-10) were also identified. Their structures were elucidated by analysis of the NMR and mass spectroscopic data. The absolute configuration of compound 1 was determined by experimental and calculated ECD spectra. Compound 2 displayed potent brine shrimp (Artemia salina) lethality with LD50 11.2 mu M.; Two new secondary metabolites, namely, pinodiketopiperazine A (1) and 6,7-dihydroxy-3-methoxy-3-methylphthalide (2), along with alternariol 2,4-dimethyl ether (3) and L-5-oxoproline methyl ester (4), which were isolated from a natural source for the first time but have been previously synthesized, were characterized from the marine sediment-derived fungus Penicillium pinophilum SD-272. In addition, six known metabolites (5-10) were also identified. Their structures were elucidated by analysis of the NMR and mass spectroscopic data. The absolute configuration of compound 1 was determined by experimental and calculated ECD spectra. Compound 2 displayed potent brine shrimp (Artemia salina) lethality with LD50 11.2 mu M. |
| 文章类型 | Article |
| 资助机构 | Ministry of Science and Technology [2013AA092901, 2010CB833802]; National Natural Science Foundation of China [31270403] |
| 收录类别 | SCI |
| 语种 | 英语 |
| 关键词[WOS] | NATURAL-PRODUCTS ; AMINO-ACIDS ; DERIVATIVES ; ALTERNARIOL ; ALKALOIDS ; ETHER |
| 研究领域[WOS] | Pharmacology & Pharmacy |
| WOS记录号 | WOS:000320772100028 |
| 引用统计 | |
| 文献类型 | 期刊论文 |
| 条目标识符 | http://ir.yic.ac.cn/handle/133337/6786 |
| 专题 | 海岸带生物学与生物资源利用重点实验室_海岸带生物学与生物资源保护实验室 |
| 作者单位 | 1.Chinese Acad Sci, Inst Oceanol, Key Lab Expt Marine Biol, Qingdao 266071, Peoples R China 2.Univ Chinese Acad Sci, Beijing 100049, Peoples R China 3.Chinese Acad Sci, Yantai Inst Coastal Zone Res, Key Lab Coastal Biol & Bioresource Utilizat, Yantai 264003, Peoples R China |
| 推荐引用方式 GB/T 7714 | Wang, Ming-Hui,Li, Xiao-Ming,Li, Chun-Shun,et al. Secondary Metabolites from Penicillium pinophilum SD-272, a Marine Sediment-Derived Fungus[J]. MARINE DRUGS,2013,11(6):2230-2238. |
| APA | Wang, Ming-Hui,Li, Xiao-Ming,Li, Chun-Shun,Ji, Nai-Yun,&Wang, Bin-Gui.(2013).Secondary Metabolites from Penicillium pinophilum SD-272, a Marine Sediment-Derived Fungus.MARINE DRUGS,11(6),2230-2238. |
| MLA | Wang, Ming-Hui,et al."Secondary Metabolites from Penicillium pinophilum SD-272, a Marine Sediment-Derived Fungus".MARINE DRUGS 11.6(2013):2230-2238. |
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