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| A pH-responsive nano-carrier with mesoporous silica nanoparticles cores and poly(acrylic acid) shell-layers: Fabrication, characterization and properties for controlled release of salidroside | |
Peng, Hailong1,2; Dong, Ruichen1; Wang, Shenqi1; Zhang, Zhong3; Luo, Mei1,2; Bai, Chunqing1; Zhao, Qiang1; Li, Jinhua3 ; Chen, Lingxin3; Xiong, Hua1
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| 发表期刊 | INTERNATIONAL JOURNAL OF PHARMACEUTICS
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| ISSN | 0378-5173 |
| 2013-03-25 | |
| 卷号 | 446期号:1-2页码:153-159 |
| 关键词 | Mesoporous Silica Nanoparticles Poly(Acrylic Acid) Ph-responsive Controlled Release Salidroside |
| 产权排序 | [Peng, Hailong; Dong, Ruichen; Wang, Shenqi; Luo, Mei; Bai, Chunqing; Zhao, Qiang; Xiong, Hua] Nanchang Univ, State Key Lab Food Sci & Technol, Nanchang 330047, Peoples R China; [Peng, Hailong; Luo, Mei] Nanchang Univ, Dept Chem Engn, Nanchang 330031, Peoples R China; [Zhang, Zhong; Li, Jinhua; Chen, Lingxin] Chinese Acad Sci, Yantai Inst Coastal Zone Res, Key Lab Coastal Zone Environm Proc, Yantai 264003, Peoples R China |
| 通讯作者 | Xiong, H (reprint author), Nanchang Univ, State Key Lab Food Sci & Technol, Nanchang 330047, Peoples R China. [email protected] |
| 作者部门 | 中科院海岸带环境过程与生态修复重点实验室 |
| 英文摘要 | A novel pH-responsive nano-carrier MSNs-PAA, possessing mesoporous silica nanoparticles (MSNs) cores and poly(acrylic acid) (PAA) shell-layers, was developed for controlled release of salidroside. The vinyl double bonds modified MSNs were synthesized by using cetyltrimethylammonium bromide (CTAB) as templates, tetraethyl orthosilicate (TEOS) as silicon source, and 3-(trimethoxylsilyl) propyl methacrylate (MPS) as surface modification functionalities. The pH-responsive layers of PAA were grafted onto the vinyl double bonds of the MSNs via precipitation polymerization, producing the MSNs-PAA with a hollow cubic core and mesoporous shell with penetrating pore channels. The characteristic results also showed that PAA was successfully grafted onto the surface of the MSNs. The MSNs-PAA was investigated as carriers for loading and regulating the release of salidroside in different pH solutions for the first time. The results demonstrated that the PAA layers on the surface of MSNs-PAA exhibited opened and closed states at different pH values, and thus could regulate the uptake and release of salidroside. The application of such pH-responsive nano-carrier might offer a potential platform for controlled delivery and increasing the bioavailability of drugs. (C) 2013 Elsevier B. V. All rights reserved.; A novel pH-responsive nano-carrier MSNs-PAA, possessing mesoporous silica nanoparticles (MSNs) cores and poly(acrylic acid) (PAA) shell-layers, was developed for controlled release of salidroside. The vinyl double bonds modified MSNs were synthesized by using cetyltrimethylammonium bromide (CTAB) as templates, tetraethyl orthosilicate (TEOS) as silicon source, and 3-(trimethoxylsilyl) propyl methacrylate (MPS) as surface modification functionalities. The pH-responsive layers of PAA were grafted onto the vinyl double bonds of the MSNs via precipitation polymerization, producing the MSNs-PAA with a hollow cubic core and mesoporous shell with penetrating pore channels. The characteristic results also showed that PAA was successfully grafted onto the surface of the MSNs. The MSNs-PAA was investigated as carriers for loading and regulating the release of salidroside in different pH solutions for the first time. The results demonstrated that the PAA layers on the surface of MSNs-PAA exhibited opened and closed states at different pH values, and thus could regulate the uptake and release of salidroside. The application of such pH-responsive nano-carrier might offer a potential platform for controlled delivery and increasing the bioavailability of drugs. (C) 2013 Elsevier B. V. All rights reserved. |
| 文章类型 | Article |
| 资助机构 | National Natural Science Foundation of China [21201098, 31160317, 21275158, 21105117]; Specialized Research Fund for the Doctoral Program of Higher Education [20113601110004]; 100 Talents Program of the Chinese Academy of Sciences |
| 收录类别 | SCI |
| 语种 | 英语 |
| 关键词[WOS] | MOLECULARLY IMPRINTED POLYMERS ; SOLID-PHASE EXTRACTION ; DRUG-DELIVERY ; RHODIOLA-ROSEA ; IN-VITRO ; SYSTEM ; CELLS ; MICROSPHERES ; PERFORMANCE ; APOPTOSIS |
| 研究领域[WOS] | Pharmacology & Pharmacy |
| WOS记录号 | WOS:000316736500019 |
| 引用统计 | |
| 文献类型 | 期刊论文 |
| 条目标识符 | http://ir.yic.ac.cn/handle/133337/6592 |
| 专题 | 中国科学院海岸带环境过程与生态修复重点实验室 |
| 作者单位 | 1.Nanchang Univ, State Key Lab Food Sci & Technol, Nanchang 330047, Peoples R China 2.Nanchang Univ, Dept Chem Engn, Nanchang 330031, Peoples R China 3.Chinese Acad Sci, Yantai Inst Coastal Zone Res, Key Lab Coastal Zone Environm Proc, Yantai 264003, Peoples R China |
| 推荐引用方式 GB/T 7714 | Peng, Hailong,Dong, Ruichen,Wang, Shenqi,et al. A pH-responsive nano-carrier with mesoporous silica nanoparticles cores and poly(acrylic acid) shell-layers: Fabrication, characterization and properties for controlled release of salidroside[J]. INTERNATIONAL JOURNAL OF PHARMACEUTICS,2013,446(1-2):153-159. |
| APA | Peng, Hailong.,Dong, Ruichen.,Wang, Shenqi.,Zhang, Zhong.,Luo, Mei.,...&Xiong, Hua.(2013).A pH-responsive nano-carrier with mesoporous silica nanoparticles cores and poly(acrylic acid) shell-layers: Fabrication, characterization and properties for controlled release of salidroside.INTERNATIONAL JOURNAL OF PHARMACEUTICS,446(1-2),153-159. |
| MLA | Peng, Hailong,et al."A pH-responsive nano-carrier with mesoporous silica nanoparticles cores and poly(acrylic acid) shell-layers: Fabrication, characterization and properties for controlled release of salidroside".INTERNATIONAL JOURNAL OF PHARMACEUTICS 446.1-2(2013):153-159. |
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