| Synthesis and antifungal activity of thiadiazole-functionalized chitosan derivatives | |
Li, Qing1 ; Ren, Jianming1,2; Dong, Fang1; Feng, Yan1,2; Gu, Guodong3; Guo, Zhanyong1
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| 发表期刊 | CARBOHYDRATE RESEARCH
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| ISSN | 0008-6215 |
| 2013-05-24 | |
| 卷号 | 373页码:103-107 |
| 关键词 | Chitosan Derivatives Antifungal Activity Thiadiazole Water Solubility |
| DOI | 10.1016 / j.carres.2013.03.001 |
| 产权排序 | [Li, Qing; Ren, Jianming; Dong, Fang; Feng, Yan; Guo, Zhanyong] Chinese Acad Sci, Yantai Inst Coastal Zone Res, Key Lab Coastal Biol & Bioresource Utilizat, Yantai 264003, Shangdong, Peoples R China; [Ren, Jianming; Feng, Yan] Chinese Acad Sci, Grad Sch, Beijing 100039, Peoples R China; [Gu, Guodong] W Virginia Univ, C Eugene Bennett Dept Chem, Morgantown, WV 26506 USA |
| 通讯作者 | Guo, ZY (reprint author), Chinese Acad Sci, Yantai Inst Coastal Zone Res, Key Lab Coastal Biol & Bioresource Utilizat, Yantai 264003, Shangdong, Peoples R China. [email protected] |
| 作者部门 | 海岸带生物学与生物资源利用所重点实验室 |
| 英文摘要 | A groups of novel water soluble chitosan derivatives containing 1,3,4-thiadiazole group were synthesized including 1,3,4-thiadiazole (TPCTS), 2-methyl-1,3,4-thiadiazole (MTPCTS), and 2-phenyl-1,3,4-thiadiazole (PTPCTS). Their antifungal activity against three kinds of phytopathogens was estimated by hypha measurement in vitro, and the fungicidal assessment shows that the synthesized chitosan derivatives have excellent activity against tested fungi. Of all the synthesized chitosan derivatives, MTPCTS inhibited the growth of the tested phytopathogens most effectively with inhibitory indices of 75.3%, 82.5%, and 65.8% against Colletotrichum lagenarium (Pass) Ell. et halst, Phomopsis asparagi (Sacc.) Bubak, and Monilinia fructicola (Wint.) Honey respectively at 1.0 mg/mL. These indices are higher than those of chitosan. These data also demonstrate that the hydrophobic moiety (alkyl and phenyl) and the length of alkyl substituent in thiadiazole tend to affect the antifungal activity of chitosan derivatives. It is hypothesized that thiadiazole groups enable the synthesized chitosan to possess obviously better antifungal activity and good solubility in water. (C) 2013 Elsevier Ltd. All rights reserved. |
| 文章类型 | Article |
| 资助机构 | National Natural Science Foundation of China [41206152]; project of National Science & Technology Pillar Program [2011 BAC02B00] ; National Natural Science Foundation of China 41206152 ; project of National Science & Technology Pillar Program 2011 BAC02B00 |
| 收录类别 | SCI |
| 语种 | 英语 |
| 关键词[WOS] | ANTIBACTERIAL ACTIVITY ; QUATERNIZED CHITOSAN ; MAILLARD REACTION ; SCHIFF-BASES ; IN-VITRO ; ANTICANCER ; CELLULASE |
| 研究领域[WOS] | Biochemistry & Molecular Biology ; Chemistry |
| WOS记录号 | WOS:000319040400018 |
| 引用统计 | |
| 文献类型 | 期刊论文 |
| 条目标识符 | http://ir.yic.ac.cn/handle/133337/6460 |
| 专题 | 海岸带生物学与生物资源利用重点实验室_海岸带生物学与生物资源保护实验室 中国科学院海岸带环境过程与生态修复重点实验室_污染过程与控制实验室 |
| 作者单位 | 1.Chinese Acad Sci, Yantai Inst Coastal Zone Res, Key Lab Coastal Biol & Bioresource Utilizat, Yantai 264003, Shangdong, Peoples R China 2.Chinese Acad Sci, Grad Sch, Beijing 100039, Peoples R China 3.W Virginia Univ, C Eugene Bennett Dept Chem, Morgantown, WV 26506 USA |
| 推荐引用方式 GB/T 7714 | Li, Qing,Ren, Jianming,Dong, Fang,et al. Synthesis and antifungal activity of thiadiazole-functionalized chitosan derivatives[J]. CARBOHYDRATE RESEARCH,2013,373:103-107. |
| APA | Li, Qing,Ren, Jianming,Dong, Fang,Feng, Yan,Gu, Guodong,&Guo, Zhanyong.(2013).Synthesis and antifungal activity of thiadiazole-functionalized chitosan derivatives.CARBOHYDRATE RESEARCH,373,103-107. |
| MLA | Li, Qing,et al."Synthesis and antifungal activity of thiadiazole-functionalized chitosan derivatives".CARBOHYDRATE RESEARCH 373(2013):103-107. |
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| Synthesis and antifu（660KB） | 期刊论文 | 出版稿 | 开放获取 | CC BY-NC-SA | 浏览 请求全文 | |
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