Effervescent tablets were prepared from organic selenium-enriched seaweed polysaccharides and inulin by absolute alcohol-acid-base two-phase granulation method. Using response surface methodology based on a three-variable, three-level central composite design, the amounts of the added lubricants sodium dodecylsulfate, magnesium stearate, and silica powder in effervescent tablet formulation were optimized to be 0.70%, 2.60% and 0.90%, respectivley. All the quality indexes fhe prepared effervescent tablets complied with the requirements of the Chinese Pharmacopoeia.
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