Ocean acidification aggravates the toxicity of deltamethrin in Haliotis discus hannai: Insights from immune response, histopathology and physiological responses

doi:10.1016/j.aquatox.2024.107139

	Ocean acidification aggravates the toxicity of deltamethrin in Haliotis discus hannai: Insights from immune response, histopathology and physiological responses
	Lv, Xiaojing 1,2,3; Deng, Qinyou 4; Chen, Lizhu 4; Wang, Xin 1; Han, Yijing 5; Wu, Guiqing 1; Liu, Yongliang 1,2; Sun, Haiyue 4; Li, Xuan 4; He, Jinxia 4; Liu, Xiangquan 4; Yang, Dinglong1,2 ; Zhao, Jianmin1,2
发表期刊	AQUATIC TOXICOLOGY
ISSN	0166-445X
	2024-12-01
卷号	277 页码:14
关键词	Haliotis discus hannai Ocean acidification Deltamethrin Integrated biomarker response
DOI	10.1016/j.aquatox.2024.107139
通讯作者	Liu, Xiangquan([email protected]) ; Yang, Dinglong([email protected])
英文摘要	Ocean acidification (OA) and other environmental factors can collectively affect marine organisms. Deltamethrin (DM), a type II pyrethroid insecticide, has been widely detected in coastal and estuarine areas, while little attention has been given to the combined effects of DM and OA. In this study, Haliotis discus hannai was exposed to three pH levels (8.1, 7.7 and 7.4) and three DM nominal concentrations (0 mu g/L, 0.6 mu g/L and 6 mu g/L) for 14 and 28 days. The results indicated that experimental acidification and/or DM exposure led to impaired immune function and pathological damage. Additionally, acidified conditions and DM exposure induced oxidative stress, and gills are more sensitive than digestive glands. With increasing p CO 2 and DM nominal concentrations, superoxide dismutase (SOD) activity decreased, whereas catalase (CAT) and glutathione S-transferase (GST) activities increased in the gills. Moreover, the expression levels of Toll-like receptor (TLR) pathway-related genes were upregulated after exposure. Integrated biomarker response (IBR) analysis proved that acidified conditions and/or DM detrimentally affected the overall fitness of H. discus hannai, and co-exposure to experimental acidification and DM was the most stressful condition. This study emphasizes the necessity of incorporating OA in future pollutant environmental assessments to better elucidate the risks of environmental disturbance.
资助机构	National Science & Technology Fundamental Resources Investigation Program of China ; Strategic Priority Research Program of the Chinese Academy of Sciences ; National Natural Science Foundation of China ; Natural Science Foundation of Shandong Province ; Youth Innovation Promotion Association of CAS
收录类别	SCI
语种	英语
关键词[WOS]	INTEGRATED BIOMARKER RESPONSE ; TOLL-LIKE RECEPTORS ; OXIDATIVE STRESS ; ANTIOXIDANT STATUS ; EASTERN OYSTERS ; MARINE BIVALVE ; FREE-RADICALS ; MECHANISMS ; MUSSEL ; CHALLENGE
研究领域[WOS]	Marine & Freshwater Biology ; Toxicology
WOS记录号	WOS:001354791100001
引用统计
文献类型	期刊论文
条目标识符	http://ir.yic.ac.cn/handle/133337/37873
专题	海岸带生物学与生物资源利用重点实验室海岸带生物学与生物资源利用重点实验室_海岸带生物资源高效利用研究与发展中心
通讯作者	Liu, Xiangquan; Yang, Dinglong
作者单位	1.Chinese Acad Sci, Yantai Inst Coastal Zone Res, Res & Dev Ctr Efficient Utilizat Coastal Bioresour, Yantai 264003, Peoples R China 2.Chinese Acad Sci, Yantai Inst Coastal Zone Res, Muping Coastal Environm Res Stn, Yantai 264003, Peoples R China 3.Univ Chinese Acad Sci, Beijing 100049, Peoples R China 4.Shandong Marine Resource & Environm Res Inst, Yantai 264006, Shandong, Peoples R China 5.Ludong Univ, Sch Fisheries, Yantai 264025, Peoples R China
推荐引用方式 GB/T 7714	Lv, Xiaojing,Deng, Qinyou,Chen, Lizhu,et al. Ocean acidification aggravates the toxicity of deltamethrin in Haliotis discus hannai: Insights from immune response, histopathology and physiological responses[J]. AQUATIC TOXICOLOGY,2024,277:14.
APA	Lv, Xiaojing.,Deng, Qinyou.,Chen, Lizhu.,Wang, Xin.,Han, Yijing.,...&Zhao, Jianmin.(2024).Ocean acidification aggravates the toxicity of deltamethrin in Haliotis discus hannai: Insights from immune response, histopathology and physiological responses.AQUATIC TOXICOLOGY,277,14.
MLA	Lv, Xiaojing,et al."Ocean acidification aggravates the toxicity of deltamethrin in Haliotis discus hannai: Insights from immune response, histopathology and physiological responses".AQUATIC TOXICOLOGY 277(2024):14.