Antimicrobial and Antioxidant Activities of N-2-Hydroxypropyltrimethyl Ammonium Chitosan Derivatives Bearing Amino Acid Schiff Bases

doi:10.3390/md20020086

	Antimicrobial and Antioxidant Activities of N-2-Hydroxypropyltrimethyl Ammonium Chitosan Derivatives Bearing Amino Acid Schiff Bases
	Cui, Jingmin 1,2,3; Ji, Xia 4; Mi, Yingqi 1,2,3; Miao, Qin 1,2,3; Dong, Fang1,3 ; Tan, Wenqiang1,3 ; Guo, Zhanyong1,2,3
发表期刊	MARINE DRUGS
	2022-02-01
卷号	20 期号:2 页码:13
关键词	N-2-hydroxypropyltrimethyl ammonium chloride chitosan amino acid Schiff bases antimicrobial activity antioxidant activity
DOI	10.3390/md20020086
通讯作者	Ji, Xia([email protected]) ; Guo, Zhanyong([email protected])
英文摘要	N-2-hydroxypropyltrimethyl ammonium chloride chitosan (HACC), a cationic quaternary ammonium salt polymer exhibiting good solubility in water, is widely used because of its low toxicity and good biocompatibility. Herein, through ion exchange reaction, we prepared N-2-hydroxypropyltrimethyl ammonium chitosan derivatives bearing amino acid Schiff bases with good biological activities. The accuracy of the structures was verified by FT-IR and H-1 NMR. The antibacterial activity, antifungal activity, and scavenging ability of DPPH radical and superoxide radical of HACC derivatives were significantly improved compared with that of HACC. In particular, HACGM (HACC-potassium 2-((2-hydroxy-3-methoxybenzylidene)amino)acetate) and HACGB (HACC-potassium 2-((5-bromo-2-hydroxybenzylidene)amino)acetate) showed good inhibitory effect on bacteria and fungi, including Staphylococcus aureus, Escherichia coli, Botrytis cinerea, and Fusarium oxysporum f. sp. cubense. The inhibition rate of HACGB on Staphylococcus aureus and Escherichia coli could reach 100% at the concentration of 0.1 mg/mL, and the inhibition rate of HACGM and HACGB on Botrytis cinerea and Fusarium oxysporum f. sp. cubense could also reach 100% at the concentration of 0.5 mg/mL. Improving antimicrobial and antioxidant activities of HACC could provide ideas and experiences for the development and utilization of chitosan derivatives.
资助机构	National Key Research and Development Program of China ; Ministry of Science and Technology of the People's Republic of China
收录类别	SCI
语种	英语
关键词[WOS]	CHLORIDE CHITOSAN ; ANTIBACTERIAL ACTIVITY ; IN-VITRO ; COMPLEXES ; CHITIN ; NANOPARTICLES ; CHALLENGES ; REMOVAL
研究领域[WOS]	Pharmacology & Pharmacy
WOS记录号	WOS:000765138500001
引用统计	被引频次：14[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	http://ir.yic.ac.cn/handle/133337/37716
专题	海岸带生物学与生物资源利用重点实验室海岸带生物学与生物资源利用重点实验室_海岸带生物资源高效利用研究与发展中心
通讯作者	Ji, Xia; Guo, Zhanyong
作者单位	1.Chinese Acad Sci, Yantai Inst Coastal Zone Res, Key Lab Coastal Biol & Bioresource Utilizat, Yantai 264003, Peoples R China 2.Univ Chinese Acad Sci, Beijing 100049, Peoples R China 3.Chinese Acad Sci, Ctr Ocean Mega Sci, Qingdao 266071, Peoples R China 4.Qilu Med Univ, Sch Pharm, Zibo 255300, Peoples R China
推荐引用方式 GB/T 7714	Cui, Jingmin,Ji, Xia,Mi, Yingqi,et al. Antimicrobial and Antioxidant Activities of N-2-Hydroxypropyltrimethyl Ammonium Chitosan Derivatives Bearing Amino Acid Schiff Bases[J]. MARINE DRUGS,2022,20(2):13.
APA	Cui, Jingmin.,Ji, Xia.,Mi, Yingqi.,Miao, Qin.,Dong, Fang.,...&Guo, Zhanyong.(2022).Antimicrobial and Antioxidant Activities of N-2-Hydroxypropyltrimethyl Ammonium Chitosan Derivatives Bearing Amino Acid Schiff Bases.MARINE DRUGS,20(2),13.
MLA	Cui, Jingmin,et al."Antimicrobial and Antioxidant Activities of N-2-Hydroxypropyltrimethyl Ammonium Chitosan Derivatives Bearing Amino Acid Schiff Bases".MARINE DRUGS 20.2(2022):13.