Chromatographic performance of zidovudine imprinted polymers coated silica stationary phases

doi:10.1016/j.talanta.2021.123115

	Chromatographic performance of zidovudine imprinted polymers coated silica stationary phases
	Song, Zhihua 1; Song, Yanqin 1,3; Wang, Yinghao 1; Liu, Jinqiu 1; Wang, Yumeng 1; Lin, Wen 1; Wang, Yaqi 1; Li, Jinhua2 ; Ma, Jiping 4; Yang, Gangqiang 1; Chen, Lingxin2
发表期刊	TALANTA
ISSN	0039-9140
	2022-03-01
卷号	239 页码:8
关键词	Molecularly imprinted polymers (MIPs) High performance liquid chromatography Stationary phases Silica microbeads Nucleoside analogues
DOI	10.1016/j.talanta.2021.123115
通讯作者	Song, Zhihua([email protected]) ; Yang, Gangqiang([email protected]) ; Chen, Lingxin([email protected])
英文摘要	Nowadays, molecularly imprinted polymers (MIPs) coated silica stationary phases (SPs) have aroused great attention, owing to their good properties of high selectivity, good stability, facile synthesis procedure and low cost. In this study, zidovudine imprinted polymers coated silica stationary phases (MIPs/SiO2 SPs) were synthesized by surface imprinting technique using zidovudine as the template molecule, methacrylic acid as the functional monomer, ethylene glycol dimethacrylate as the cross-linking agent, azobisisobutyronitrile as the initiator, and bare silica spheres (particle size, 5 mu m; pore size, 20 nm) as substrates. In the process, reagents with low concentration were used to prepare thin layer of MIPs coating on the surface of silica microbeads. The properties of the materials were characterized by scanning electron microscope (SEM), fourier transform infrared spectrometer (FT-IR), carbon elemental analysis and N-2 adsorption-desorption experiment. The obtained SPs were packed into stainless steel columns (2.1 mm x 150 mm) via a slurry method. The prepared columns were applied for separation of nucleoside analogues with similar chemical structures and strong polarity. The retention mechanism of MIPs/SiO2 SPs for nucleoside analogues was investigated carefully. And the chromatographic performances of the resulting MIPs based SPs were superior to those of the commercial SPs. Furthermore, the synthesized MIPs/SiO2 SPs possessed great potentials in separation of ginsenosides. This investigation demonstrated that MIPs based SPs were successfully synthesized and provided a new approach to polar compounds separation and analysis.
资助机构	Science and Technology Innovation Development Plan of Yantai ; National Demonstration Center for Experimental Pharmacy Education (Yantai University) ; National Natural Science Foundation of China ; Taishan Scholar Project Special Funding
收录类别	SCI
语种	英语
关键词[WOS]	NANOPARTICLES ; SEPARATION ; ENANTIOMER
研究领域[WOS]	Chemistry
WOS记录号	WOS:000763562000003
引用统计	被引频次：12[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	http://ir.yic.ac.cn/handle/133337/37710
专题	中国科学院海岸带环境过程与生态修复重点实验室中国科学院海岸带环境过程与生态修复重点实验室_海岸带信息集成与战略规划研究中心
通讯作者	Song, Zhihua; Yang, Gangqiang; Chen, Lingxin
作者单位	1.Yantai Univ, Minist Educ, Sch Pharm,Key Lab Mol Pharmacol & Drug Evaluat, Collaborat Innovat Ctr Adv Drug Delivery Syst & B, Yantai 264005, Peoples R China 2.Chinese Acad Sci, Res Ctr Coastal Environm Engn & Technol, Yantai Inst Coastal Zone Res, CAS Key Lab Coastal Environm Proc & Ecol Remediat, Yantai 264003, Peoples R China 3.Yantai Ctr Food & Drug Control, Yantai 264000, Peoples R China 4.Qingdao Univ Technol, Sch Environm & Municipal Engn, Qingdao 266033, Peoples R China
推荐引用方式 GB/T 7714	Song, Zhihua,Song, Yanqin,Wang, Yinghao,et al. Chromatographic performance of zidovudine imprinted polymers coated silica stationary phases[J]. TALANTA,2022,239:8.
APA	Song, Zhihua.,Song, Yanqin.,Wang, Yinghao.,Liu, Jinqiu.,Wang, Yumeng.,...&Chen, Lingxin.(2022).Chromatographic performance of zidovudine imprinted polymers coated silica stationary phases.TALANTA,239,8.
MLA	Song, Zhihua,et al."Chromatographic performance of zidovudine imprinted polymers coated silica stationary phases".TALANTA 239(2022):8.