Near-Infrared Light-Responsive SERS Tags Enable Positioning and Monitoring of the Drug Release of Photothermal Nanomedicines In Vivo

doi:10.1021/acs.analchem.1c03949

	Near-Infrared Light-Responsive SERS Tags Enable Positioning and Monitoring of the Drug Release of Photothermal Nanomedicines In Vivo
	Mei, Rongchao 1,2,3; Wang, Yunqing2,3 ; Zhao, Xizhen 2; Kang, Qi 1; Shen, Dazhong 1; Chen, Lingxin2,4
发表期刊	ANALYTICAL CHEMISTRY
ISSN	0003-2700
	2021-12-14
卷号	93 期号:49 页码:16590-16597
DOI	10.1021/acs.analchem.1c03949
通讯作者	Kang, Qi([email protected]) ; Chen, Lingxin([email protected])
英文摘要	Understanding the in vivo behavior of photothermal nanomedicines (PTNMs) is important for drug development and evaluation. However, it is still very challenging. Herein, two key parameters, i.e., the depth of PTNMs under biological tissue and the drug release ratio of PTNMs in vivo, can be revealed by a near-infrared (NIR) light-responsive surface-enhanced Raman scattering (SERS) strategy. The fabricated PTNMs were composed of waxberry-like gold nanoparticles, model drug curcumin, and an elaborately selected NIR light-responsive Raman reporter (3,3'-diethylthiatricarbocyanine iodide, DTTC). The response mechanism of DTTC to NIR light was investigated as photodegradation. NIR light irradiation heated the gold nanoparticles, triggered the release of a model drug, and simultaneously decreased the SERS intensity of the PTNMs. In vitro experiment results revealed that the SERS intensity decrease could well reflect the depth of PTNMs with a correlation coefficient of more than 0.99. On this basis, after in situ SERS detection, the depth of PTNMs in a tumor could be revealed with satisfactory accuracy. Moreover, the decrease in the SERS intensity of PTNMs showed a highly similar trend to the increase in the drug release, suggesting that it could be used for real-time monitoring of drug release of PTNMs. This study not only opens a new avenue for the release study of many inactive fluorescent and Raman drugs of PTNMs but also provides an effective way for reporting the depth, which greatly promotes the application of PTNMs in vivo.
资助机构	National Natural Science Foundation of China ; Science and Technology Development Plan of Shandong Province of China ; Youth Innovation Promotion Association CAS ; Instrument Developing Project of the Chinese Academy of Sciences
收录类别	SCI
语种	英语
关键词[WOS]	NANOPARTICLES ; STABILITY ; LIPOSOMES ; DELIVERY ; THERAPY ; VITRO
研究领域[WOS]	Chemistry
WOS记录号	WOS:000753032200037
引用统计	被引频次：12[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	http://ir.yic.ac.cn/handle/133337/37620
专题	中国科学院海岸带环境过程与生态修复重点实验室中国科学院海岸带环境过程与生态修复重点实验室_海岸带环境工程技术研究与发展中心
通讯作者	Kang, Qi; Chen, Lingxin
作者单位	1.Shandong Normal Univ, Coll Chem Chem Engn & Mat Sci, Key Lab Mol & Nano Probes, Minist Educ, Jinan 250014, Peoples R China 2.Chinese Acad Sci, Yantai Inst Coastal Zone Res, CAS Key Lab Coastal Environm Proc & Ecol Remediat, Yantai 264003, Peoples R China 3.Yantai Univ, Collaborat Innovat Ctr Adv Drug Delivery Syst & B, Key Lab Mol Pharmacol & Drug Evaluat, Sch Pharm,Minist Educ, Yantai 264005, Peoples R China 4.Binzhou Med Univ, Sch Pharm, Yantai 264003, Peoples R China
推荐引用方式 GB/T 7714	Mei, Rongchao,Wang, Yunqing,Zhao, Xizhen,et al. Near-Infrared Light-Responsive SERS Tags Enable Positioning and Monitoring of the Drug Release of Photothermal Nanomedicines In Vivo[J]. ANALYTICAL CHEMISTRY,2021,93(49):16590-16597.
APA	Mei, Rongchao,Wang, Yunqing,Zhao, Xizhen,Kang, Qi,Shen, Dazhong,&Chen, Lingxin.(2021).Near-Infrared Light-Responsive SERS Tags Enable Positioning and Monitoring of the Drug Release of Photothermal Nanomedicines In Vivo.ANALYTICAL CHEMISTRY,93(49),16590-16597.
MLA	Mei, Rongchao,et al."Near-Infrared Light-Responsive SERS Tags Enable Positioning and Monitoring of the Drug Release of Photothermal Nanomedicines In Vivo".ANALYTICAL CHEMISTRY 93.49(2021):16590-16597.