Synthesis, Characterization, and the Antioxidant Activity of Phenolic Acid Chitooligosaccharide Derivatives

doi:10.3390/md20080489

	Synthesis, Characterization, and the Antioxidant Activity of Phenolic Acid Chitooligosaccharide Derivatives
	Sun, Yan 1,2; Ji, Xia 3; Cui, Jingmin 1,2; Mi, Yingqi 1,2; Zhang, Jingjing 1,2; Guo, Zhanyong1,2
发表期刊	MARINE DRUGS
	2022-08-01
卷号	20 期号:8 页码:16
关键词	chitooligosaccharide derivatives phenolic acid antioxidant activity
DOI	10.3390/md20080489
英文摘要	A series of phenolic acid chitooligosaccharide (COS) derivatives synthesized by two mild and green methods were illuminated in this paper. Seven phenolic acids were selected to combine two kinds of COS derivatives: the phenolic acid chitooligosaccharide salt derivatives and the phenolic-acid-acylated chitooligosaccharide derivatives. The structures of the derivatives were characterized by FT-IR and H-1 NMR spectra. The antioxidant experiment results in vitro (including DPPH-radical scavenging activity, superoxide-radical scavenging activity, hydroxyl-radical scavenging ability, and reducing power) demonstrated that the derivatives exhibited significantly enhanced antioxidant activity compared to COS. Moreover, the study showed that the phenolic acid chitooligosaccharide salts had stronger antioxidant activity than phenolic-acid-acylated chitooligosaccharide. The cytotoxicity assay of L929 cells in vitro indicated that the derivatives had low cytotoxicity and good biocompatibility. In conclusion, this study provides a possible synthetic method for developing novel and nontoxic antioxidant agents which can be used in the food and cosmetics industry.
收录类别	SCI
语种	英语
关键词[WOS]	FUNCTIONALIZED CHITOSAN DERIVATIVES ; FREE-RADICALS ; FLAVONOIDS ; HEALTH
研究领域[WOS]	Pharmacology & Pharmacy
WOS记录号	WOS:000845534400001
引用统计	被引频次：16[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	http://ir.yic.ac.cn/handle/133337/37408
专题	海岸带生物学与生物资源利用重点实验室海岸带生物学与生物资源利用重点实验室_海岸带生物资源高效利用研究与发展中心
通讯作者	Ji, Xia; Guo, Zhanyong
作者单位	1.Chinese Acad Sci, Yantai Inst Coastal Zone Res, Key Lab Coastal Biol & Bioresource Utilizat, Yantai 264003, Peoples R China 2.Univ Chinese Acad Sci, Beijing 100049, Peoples R China 3.Qilu Med Univ, Sch Pharm, Zibo 255300, Peoples R China
推荐引用方式 GB/T 7714	Sun, Yan,Ji, Xia,Cui, Jingmin,et al. Synthesis, Characterization, and the Antioxidant Activity of Phenolic Acid Chitooligosaccharide Derivatives[J]. MARINE DRUGS,2022,20(8):16.
APA	Sun, Yan,Ji, Xia,Cui, Jingmin,Mi, Yingqi,Zhang, Jingjing,&Guo, Zhanyong.(2022).Synthesis, Characterization, and the Antioxidant Activity of Phenolic Acid Chitooligosaccharide Derivatives.MARINE DRUGS,20(8),16.
MLA	Sun, Yan,et al."Synthesis, Characterization, and the Antioxidant Activity of Phenolic Acid Chitooligosaccharide Derivatives".MARINE DRUGS 20.8(2022):16.