Phycocyanin: Anti-inflammatory effect and mechanism

doi:10.1016/j.biopha.2022.113362

	Phycocyanin: Anti-inflammatory effect and mechanism
	Liu, Runze 1; Qin, Song1,2 ; Li, Wenjun1,2
发表期刊	BIOMEDICINE & PHARMACOTHERAPY
ISSN	0753-3322
	2022-09-01
卷号	153 页码:10
关键词	Phycocyanin Phycocyanobilin Inflammation Signal pathway Heme oxygenase 1 Kelch-like ECH-associated protein 1
DOI	10.1016/j.biopha.2022.113362
英文摘要	As the host defense response to various injuries and pathogens in the body, inflammation can remove damaged cells and pathogens in the host organism and protect the body. However, excessive inflammation may cause damage to normal tissue cells while removing pathogens, which in turn cause numerous inflammatory diseases and adversely affect the human health. Phycocyanin is an active substance extracted from algae; it has outstanding antioxidant and anti-inflammatory activities, and can effectively inhibit various diseases caused by inflammation. This review systematically summarizes recent applications of phycocyanin against various inflammatory diseases in lung, liver, cardiovascular, and cerebrovascular systems. In addition, possible antiinflammatory action pathways of phycocyanin are reviewed to canvass the anti-inflammatory mechanism. At last, based on the existing research, phycocyanobilin in phycocyanin is proposed as a bilirubin analog by inducing heme oxygenase 1 in vivo to suppress inflammation.
收录类别	SCI
语种	英语
关键词[WOS]	C-PHYCOCYANIN ; HEME OXYGENASE-1 ; SPIRULINA-PLATENSIS ; REDUCES INFLAMMATION ; BILIRUBIN ; ACTIVATION ; IMMUNE ; INJURY ; EXPRESSION ; APOPTOSIS
研究领域[WOS]	Research & Experimental Medicine ; Pharmacology & Pharmacy
WOS记录号	WOS:000850076300002
引用统计	被引频次：42[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	http://ir.yic.ac.cn/handle/133337/37352
专题	海岸带生物学与生物资源利用重点实验室海岸带生物学与生物资源利用重点实验室_海岸带生物学与生物资源保护实验室
通讯作者	Li, Wenjun
作者单位	1.Chinese Acad Sci, Yantai Inst Coastal Zone Res, Yantai 264003, Shandong, Peoples R China 2.Chinese Acad Sci, Ctr Ocean Megasci, Qingdao 266071, Peoples R China
推荐引用方式 GB/T 7714	Liu, Runze,Qin, Song,Li, Wenjun. Phycocyanin: Anti-inflammatory effect and mechanism[J]. BIOMEDICINE & PHARMACOTHERAPY,2022,153:10.
APA	Liu, Runze,Qin, Song,&Li, Wenjun.(2022).Phycocyanin: Anti-inflammatory effect and mechanism.BIOMEDICINE & PHARMACOTHERAPY,153,10.
MLA	Liu, Runze,et al."Phycocyanin: Anti-inflammatory effect and mechanism".BIOMEDICINE & PHARMACOTHERAPY 153(2022):10.