| Synthesis and characterization of self-assembled CdHgTe/gelatin nanospheres as stable near infrared fluorescent probes in vivo | |
Wang, Yunqing1,2,3 ; Ye, Chao1,2; Wu, Liheng1,2; Hu, Yuzhu1,2
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| 发表期刊 | JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS
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| ISSN | 0731-7085 |
| 2010-11-02 | |
| 卷号 | 53期号:3页码:235-242 |
| 关键词 | Cdhgte/gelatin Nanospheres Biomimetic Synthesis Fluorescent Probes Near Infrared Imaging In Vivo Visible Drug Nanocarriers |
| 产权排序 | [Wang, Yunqing; Ye, Chao; Wu, Liheng; Hu, Yuzhu] Minist Educ, Key Lab Drug Qual Control & Pharmacovigilance, Nanjing 210009, Peoples R China; [Wang, Yunqing; Ye, Chao; Wu, Liheng; Hu, Yuzhu] China Pharmaceut Univ, Dept Analyt Chem, Nanjing 210009, Peoples R China; [Wang, Yunqing] Chinese Acad Sci, Yantai Inst Coastal Zone Res, Yantai 264003, Peoples R China |
| 通讯作者 | Hu, YZ, Minist Educ, Key Lab Drug Qual Control & Pharmacovigilance, Nanjing 210009, Peoples R China |
| 作者部门 | 环境化学实验室 |
| 英文摘要 | This work presented a kind of novel near infrared emitting CdHgTe/gelatin nanospheres which were synthesized with Cd(NO3)(2), Hg(NO3)(2). NaHTe and a thiol stabilizer in gelatin solution The self-assembled nanospheres were megranate-like and nearly 40 nm in diameter, with CdHgTe QDs uniformly embedded in gelatin matrix. They exhibited strong fluorescence ranging from 580 to 800 nm that could be tuned by molar ratios of Hg2+ and gelatin. The full widths at half-maximum of the emission spectra were in the range of 60-80 nm. Compared with bare CdHgTe QDs, the photostability of this compact complex nanostructure remarkably improved. Moreover, the fluorescence of CdHgTe/gelatin nanospheres was much more resistant to the interference from certain kinds of endogenous biomolecules such as HSA, transferrin and hemoglobin Further applications of living cells and mouse imaging were demonstrated with an in vivo near infrared fluorescence imaging system The Inherent advantages of high stability as well as high fluorescence intensity make the nanospheres particular interested NIR bioprobe candidates for in vivo imaging studies (C) 2010 Elsevier B.V. All rights reserved; This work presented a kind of novel near infrared emitting CdHgTe/gelatin nanospheres which were synthesized with Cd(NO(3))(2), Hg(NO(3))(2). NaHTe and a thiol stabilizer in gelatin solution The self-assembled nanospheres were megranate-like and nearly 40 nm in diameter, with CdHgTe QDs uniformly embedded in gelatin matrix. They exhibited strong fluorescence ranging from 580 to 800 nm that could be tuned by molar ratios of Hg(2+) and gelatin. The full widths at half-maximum of the emission spectra were in the range of 60-80 nm. Compared with bare CdHgTe QDs, the photostability of this compact complex nanostructure remarkably improved. Moreover, the fluorescence of CdHgTe/gelatin nanospheres was much more resistant to the interference from certain kinds of endogenous biomolecules such as HSA, transferrin and hemoglobin Further applications of living cells and mouse imaging were demonstrated with an in vivo near infrared fluorescence imaging system The Inherent advantages of high stability as well as high fluorescence intensity make the nanospheres particular interested NIR bioprobe candidates for in vivo imaging studies (C) 2010 Elsevier B.V. All rights reserved |
| 文章类型 | Article |
| 收录类别 | SCI ; ISTP |
| 语种 | 英语 |
| 关键词[WOS] | QUANTUM DOTS ; MOUSE MODEL ; NANOPARTICLES ; GROWTH |
| 研究领域[WOS] | Chemistry ; Pharmacology & Pharmacy |
| WOS记录号 | WOS:000280435800003 |
| 引用统计 | |
| 文献类型 | 期刊论文 |
| 条目标识符 | http://ir.yic.ac.cn/handle/133337/3731 |
| 专题 | 中国科学院海岸带环境过程与生态修复重点实验室_环境化学实验室 |
| 作者单位 | 1.Minist Educ, Key Lab Drug Qual Control & Pharmacovigilance, Nanjing 210009, Peoples R China 2.China Pharmaceut Univ, Dept Analyt Chem, Nanjing 210009, Peoples R China 3.Chinese Acad Sci, Yantai Inst Coastal Zone Res, Yantai 264003, Peoples R China |
| 推荐引用方式 GB/T 7714 | Wang, Yunqing,Ye, Chao,Wu, Liheng,et al. Synthesis and characterization of self-assembled CdHgTe/gelatin nanospheres as stable near infrared fluorescent probes in vivo[J]. JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS,2010,53(3):235-242. |
| APA | Wang, Yunqing,Ye, Chao,Wu, Liheng,&Hu, Yuzhu.(2010).Synthesis and characterization of self-assembled CdHgTe/gelatin nanospheres as stable near infrared fluorescent probes in vivo.JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS,53(3),235-242. |
| MLA | Wang, Yunqing,et al."Synthesis and characterization of self-assembled CdHgTe/gelatin nanospheres as stable near infrared fluorescent probes in vivo".JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS 53.3(2010):235-242. |
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