Green Extraction of Phenolic Compounds from Lotus (Nelumbo nucifera Gaertn) Leaf Using Deep Eutectic Solvents: Process Optimization and Antioxidant Activity

doi:10.3390/separations10050272

	Green Extraction of Phenolic Compounds from Lotus (Nelumbo nucifera Gaertn) Leaf Using Deep Eutectic Solvents: Process Optimization and Antioxidant Activity
	Yang, Jiwei 1; Yan, Zhi 2,3; Li, Lingna 1; Zhang, Lifen 1; Zhao, Mengjian 1; Yi, Huixiang 1; Wang, Ziying 1; Li, Gang 1; Wang, Zhenhua 1; Li, Mei 1; Ma, Chengjun 1
发表期刊	SEPARATIONS
	2023-04-22
卷号	10 期号:5 页码:17
关键词	deep eutectic solvents lotus (Nelumbo nucifera Gaertn ) leaves extraction response surface methodology antioxidant flavonoids polyphenols
DOI	10.3390/separations10050272
通讯作者	Li, Mei([email protected]) ; Ma, Chengjun([email protected])
英文摘要	Natural deep eutectic solvents (NDESs) were used to extract flavonoids and polyphenols from lotus (Nelumbo nucifera Gaertn.) leaves at the same time, and the extraction process was optimized to provide reference for the effective development and utilization of lotus leaves. The deep eutectic solvents (DESs) with the highest yield of flavonoids and polyphenols were screened out from 19 different NDES combinations. The response surface method was employed to optimize the extraction process. After a rational design, a lactic acid/glycerol (molar ratio 1:2) DES was chosen as the optimal extraction solvent, and the optimum extraction parameters were as follow: water content (29%), liquid-solid ratio (37:1 mL/g), extraction time (61 min), and extraction temperature (53 degrees C). Compared with traditional water extraction or ethanol extraction, it improved the yield of flavonoids (126.10 mg/g) and polyphenols (126.10 mg/g). By LC-MS analysis, 19 flavonoids or organic acid compounds with known compound structural formulae were identified in the DES extract of lotus leaves. By comparing the free radical scavenging ability and total reducing ability, the extraction of lotus leaves using the NDES method was superior to both ethanol extraction and water extraction. It is a green, environmentally friendly, and efficient extraction method for antioxidants from leaves of Nelumbo nucifera Gaertn.
资助机构	Shandong Provincial Natural Science Foundation, China ; Innovation Platform for the Development and Construction of Special Project of Qinghai Province
收录类别	SCI
语种	英语
关键词[WOS]	FLAVONOIDS ; METABOLITES ; LEAVES ; WATER
研究领域[WOS]	Chemistry
WOS记录号	WOS:000996594900001
引用统计	被引频次：7[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	http://ir.yic.ac.cn/handle/133337/36927
专题	中国科学院烟台海岸带研究所知识产出
通讯作者	Li, Mei; Ma, Chengjun
作者单位	1.Yantai Univ, Coll Life Sci, Ctr Mitochondria & Hlth Aging, Yantai 264005, Peoples R China 2.Chinese Acad Sci, Yantai Inst Coastal Zone Res, Yantai 264003, Peoples R China 3.Yantai Univ, Sch Ocean, Yantai 264005, Peoples R China
推荐引用方式 GB/T 7714	Yang, Jiwei,Yan, Zhi,Li, Lingna,et al. Green Extraction of Phenolic Compounds from Lotus (Nelumbo nucifera Gaertn) Leaf Using Deep Eutectic Solvents: Process Optimization and Antioxidant Activity[J]. SEPARATIONS,2023,10(5):17.
APA	Yang, Jiwei.,Yan, Zhi.,Li, Lingna.,Zhang, Lifen.,Zhao, Mengjian.,...&Ma, Chengjun.(2023).Green Extraction of Phenolic Compounds from Lotus (Nelumbo nucifera Gaertn) Leaf Using Deep Eutectic Solvents: Process Optimization and Antioxidant Activity.SEPARATIONS,10(5),17.
MLA	Yang, Jiwei,et al."Green Extraction of Phenolic Compounds from Lotus (Nelumbo nucifera Gaertn) Leaf Using Deep Eutectic Solvents: Process Optimization and Antioxidant Activity".SEPARATIONS 10.5(2023):17.