Enhanced biological activities of coumarin-functionalized polysaccharide derivatives: Chemical modification and activity assessment

doi:10.1016/j.ijbiomac.2023.126691

	Enhanced biological activities of coumarin-functionalized polysaccharide derivatives: Chemical modification and activity assessment
	Li, Qing1 ; Yang, Yunhui 1,2; Li, Yijian 3; Mi, Yingqi 1,5; Ma, Xuanxuan 4; Jiang, Aili 2; Guo, Zhanyong1
发表期刊	INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
ISSN	0141-8130
	2023-12-31
卷号	253 页码:13
关键词	Polysaccharide Chemical modification Coumarins
DOI	10.1016/j.ijbiomac.2023.126691
通讯作者	Guo, Zhanyong([email protected])
英文摘要	Natural polysaccharides are abundant and renewable resource, but their applications are hampered by limited biological activity. Chemical modification can overcome these drawbacks by altering their structure. Three series of polysaccharide derivatives with coumarins were synthesized to obtain polysaccharide derivatives with enhanced biological activity. The biological activities were tested, including antioxidant property, antifungal property, and antibacterial property. Based on the results, the inhibitory properties of the coumarin-polysaccharide derivatives were significantly improved over the raw polysaccharide. The IC50 of the inhibition of DPPH, ABTS(center dot+), and superoxide (O-2(center dot-)) radical-scavenging was 0.06-0.15 mg/mL, 2.3-15.9 mu g/mL, and 0.03-0.25 mg/mL, respectively. Compared with the raw polysaccharides, coumarin-polysaccharide derivatives exhibited higher efficacy in inhibiting the growth of tested phytopathogens, showing inhibitory indices of 60.0-93.6 % at 1.0 mg/mL. Chitosan derivatives with methyl and chlorine (Compound 10B and 10C) exhibited significant antibacterial activity against S. aureus (MIC = 31.2 mu g/mL), E. coli (MIC = 7.8 mu g/mL), and V. harveyi (MIC = 15.6 mu g/mL), respectively. The results of the cytotoxicity assay showed no observed cytotoxicity when the RAW 264.7 cells were incubated with the synthesized polysaccharide derivatives at the tested concentrations.
资助机构	Science and Technology Specific Projects in Agricul-tural High-tech Industrial Demonstration Area of the Yellow River Delta ; National Natural Science Foundation of China ; 2022 Central Guiding Local Science and Technology Development Fund Project in Shandong Province
收录类别	SCI
语种	英语
关键词[WOS]	RADICAL-SCAVENGING ACTIVITY ; ANTIOXIDANT ACTIVITY ; CHITOSAN DERIVATIVES ; ANTICANCER AGENTS ; DESIGN ; DPPH
研究领域[WOS]	Biochemistry & Molecular Biology ; Chemistry ; Polymer Science
WOS记录号	WOS:001075112600001
引用统计	被引频次：5[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	http://ir.yic.ac.cn/handle/133337/36713
专题	海岸带生物学与生物资源利用重点实验室海岸带生物学与生物资源利用重点实验室_海岸带生物资源高效利用研究与发展中心
通讯作者	Guo, Zhanyong
作者单位	1.Chinese Acad Sci, Yantai Inst Coastal Zone Res, Key Lab Coastal Biol & Bioresource Utilizat, Yantai 264003, Peoples R China 2.Yantai Univ, Coll Life Sci, Yantai 264003, Peoples R China 3.China Univ Petr, Coll Chemisry & Chem Engn, Qingdao 266580, Peoples R China 4.Ludong Univ, Sch Resources & Environm Engn, Yantai 264025, Peoples R China 5.Shandong Saline Alkali Land Modern Agr Co, Dongying 257300, Peoples R China
推荐引用方式 GB/T 7714	Li, Qing,Yang, Yunhui,Li, Yijian,et al. Enhanced biological activities of coumarin-functionalized polysaccharide derivatives: Chemical modification and activity assessment[J]. INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES,2023,253:13.
APA	Li, Qing.,Yang, Yunhui.,Li, Yijian.,Mi, Yingqi.,Ma, Xuanxuan.,...&Guo, Zhanyong.(2023).Enhanced biological activities of coumarin-functionalized polysaccharide derivatives: Chemical modification and activity assessment.INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES,253,13.
MLA	Li, Qing,et al."Enhanced biological activities of coumarin-functionalized polysaccharide derivatives: Chemical modification and activity assessment".INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES 253(2023):13.