Preparation and Antioxidant Activity of New Carboxymethyl Chitosan Derivatives Bearing Quinoline Groups

doi:10.3390/md21120606

	Preparation and Antioxidant Activity of New Carboxymethyl Chitosan Derivatives Bearing Quinoline Groups
	Wang, Linqing 1,2,3; Guo, Rui 1,2,3; Liang, Xiaorui 4; Ji, Yuting 1,2,3; Zhang, Jingjing 1,2; Gai, Guowei 5; Guo, Zhanyong1,2,3
发表期刊	MARINE DRUGS
	2023-12-01
卷号	21 期号:12 页码:21
关键词	antioxidant activity carboxymethyl chitosan derivatives quinoline
DOI	10.3390/md21120606
通讯作者	Zhang, Jingjing([email protected]) ; Guo, Zhanyong([email protected])
英文摘要	A total of 16 novel carboxymethyl chitosan derivatives bearing quinoline groups in four classes were prepared by different synthetic methods. Their chemical structures were confirmed by Fourier-transform infrared spectroscopy (FTIR), nuclear magnetic resonance (NMR), and elemental analysis. The antioxidant experiment results in vitro (including DPPH radical scavenging ability, superoxide anion radical scavenging ability, hydroxyl radical scavenging ability, and ferric reducing antioxidant power) demonstrated that adding quinoline groups to chitosan (CS) and carboxymethyl chitosan (CMCS) enhanced the radical scavenging ability of CS and CMCS. Among them, both N, O-CMCS derivatives and N-TM-O-CMCS derivatives showed DPPH radical scavenging over 70%. In addition, their scavenging of superoxide anion radicals reached more than 90% at the maximum tested concentration of 1.6 mg/mL. Moreover, the cytotoxicity assay was carried out on L929 cells by the MTT method, and the results indicated that all derivatives showed no cytotoxicity (cell viability > 75%) except O-CMCS derivative 1a, which showed low cytotoxicity at 1000 mu g/mL (cell viability 50.77 +/- 4.67%). In conclusion, the carboxymethyl chitosan derivatives bearing quinoline groups showed remarkable antioxidant ability and weak cytotoxicity, highlighting their potential use in food and medical applications.
资助机构	Natural Science Foundation of Shandong Province of China ; Institutional Center for the shared technologies and facilities of the Yantai Institute of Coastal Zone Research
收录类别	SCI
语种	英语
关键词[WOS]	COMPOSITE
研究领域[WOS]	Pharmacology & Pharmacy
WOS记录号	WOS:001132743900001
引用统计	被引频次：7[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	http://ir.yic.ac.cn/handle/133337/36557
专题	海岸带生物学与生物资源利用重点实验室海岸带生物学与生物资源利用重点实验室_海岸带生物资源高效利用研究与发展中心
通讯作者	Zhang, Jingjing; Guo, Zhanyong
作者单位	1.Chinese Acad Sci, Key Lab Coastal Biol & Bioresource Utilizat, Yantai Inst Coastal Zone Res, Yantai 264003, Peoples R China 2.Chinese Acad Sci, Ctr Ocean Mega Sci, 7 Nanhai Rd, Qingdao 266071, Peoples R China 3.Univ Chinese Acad Sci, Beijing 100049, Peoples R China 4.Naval Aviat Univ, Sch Basic Sci Aviat, Yantai 264001, Peoples R China 5.Shandong Saline Alkali Land Modern Agr Co, Dongying 257300, Peoples R China
推荐引用方式 GB/T 7714	Wang, Linqing,Guo, Rui,Liang, Xiaorui,et al. Preparation and Antioxidant Activity of New Carboxymethyl Chitosan Derivatives Bearing Quinoline Groups[J]. MARINE DRUGS,2023,21(12):21.
APA	Wang, Linqing.,Guo, Rui.,Liang, Xiaorui.,Ji, Yuting.,Zhang, Jingjing.,...&Guo, Zhanyong.(2023).Preparation and Antioxidant Activity of New Carboxymethyl Chitosan Derivatives Bearing Quinoline Groups.MARINE DRUGS,21(12),21.
MLA	Wang, Linqing,et al."Preparation and Antioxidant Activity of New Carboxymethyl Chitosan Derivatives Bearing Quinoline Groups".MARINE DRUGS 21.12(2023):21.