NIR-activatable nitric oxide generator based on nanoparticles loaded small-molecule photosensitizers for synergetic photodynamic/gas therapy

doi:10.1186/s12951-024-02878-7

	NIR-activatable nitric oxide generator based on nanoparticles loaded small-molecule photosensitizers for synergetic photodynamic/gas therapy
	Fu, Lili 1,3; Huang, Yan 1; Shan, Xin 4; Sun, Xiao 1; Wang, Xinlei 1; Wang, Xiaoyan 1; Chen, Lingxin1,2 ; Yu, Shui 1
发表期刊	JOURNAL OF NANOBIOTECHNOLOGY
	2024-10-01
卷号	22 期号:1 页码:15
关键词	Photodynamic therapy Nanoplatforms Mesoporous silica materials Small-molecule photosensitizers Nitric oxide release
DOI	10.1186/s12951-024-02878-7
通讯作者	Huang, Yan([email protected]) ; Chen, Lingxin([email protected]) ; Yu, Shui([email protected])
英文摘要	BackgroundTherapeutic approaches that combine conventional photodynamic therapy (PDT) with gas therapy (GT) to sensitize PDT are an attractive strategy, but the molecular structure design of the complex lacks effective guiding strategies.ResultsHerein, we have developed a nanoplatforms Cy-NMNO@SiO2 based on mesoporous silica materials loaded NIR-activatable small-molecule fluorescent probe Cy-NMNO for the synergistic treatment of photodynamic therapy/gas therapy (PDT/GT) in antibacterial and skin cancer. The theoretical calculation results showed that the low dissociation of N-NO in Cy-NMNO enabled it to dissociate effectively under NIR light irradiation, which is conducive to produce Cy and NO. Cy showed better 1O2 generation performance than Cy-NMNO. The cytotoxicity of Cy-NMNO obtained via the synergistic effect of GT and PDT synergistically enhances the effect of photodynamic therapy, thus achieving more effective tumor treatment and sterilization than conventional PDT. Moreover, the nanoplatforms Cy-NMNO@SiO2 realized efficient drug loading and drug delivery.ConclusionsThis work not only offers a promising approach for PDT-GT synergistic drug delivery system, but also provides a valuable reference for the design of its drug molecules.
资助机构	National Natural Science Foundation of China
收录类别	SCI
语种	英语
关键词[WOS]	MESOPOROUS SILICA NANOPARTICLES ; HYPOXIA ; HIF-1
研究领域[WOS]	Biotechnology & Applied Microbiology ; Science & Technology - Other Topics
WOS记录号	WOS:001326709800001
引用统计
文献类型	期刊论文
条目标识符	http://ir.yic.ac.cn/handle/133337/36525
专题	中国科学院海岸带环境过程与生态修复重点实验室中国科学院海岸带环境过程与生态修复重点实验室_海岸带环境工程技术研究与发展中心
通讯作者	Huang, Yan; Chen, Lingxin; Yu, Shui
作者单位	1.Binzhou Med Univ, Sch Pharm, Yantai 264003, Peoples R China 2.Chinese Acad Sci, Yantai Inst Coastal Zone Res, CAS Key Lab Coastal Environm Proc & Ecol Remediat, Yantai 264003, Peoples R China 3.Shandong Normal Univ, Coll Chem Chem Engn & Mat Sci, Jinan 250014, Shandong, Peoples R China 4.Shandong City Serv Inst, Dept Intelligent Mfg, Yantai 264003, Peoples R China
推荐引用方式 GB/T 7714	Fu, Lili,Huang, Yan,Shan, Xin,et al. NIR-activatable nitric oxide generator based on nanoparticles loaded small-molecule photosensitizers for synergetic photodynamic/gas therapy[J]. JOURNAL OF NANOBIOTECHNOLOGY,2024,22(1):15.
APA	Fu, Lili.,Huang, Yan.,Shan, Xin.,Sun, Xiao.,Wang, Xinlei.,...&Yu, Shui.(2024).NIR-activatable nitric oxide generator based on nanoparticles loaded small-molecule photosensitizers for synergetic photodynamic/gas therapy.JOURNAL OF NANOBIOTECHNOLOGY,22(1),15.
MLA	Fu, Lili,et al."NIR-activatable nitric oxide generator based on nanoparticles loaded small-molecule photosensitizers for synergetic photodynamic/gas therapy".JOURNAL OF NANOBIOTECHNOLOGY 22.1(2024):15.