Surface enhanced Raman scattering microtips for microenvironment pH determination of semi-solid preparations

doi:10.1039/d4ay01523a

	Surface enhanced Raman scattering microtips for microenvironment pH determination of semi-solid preparations
	Lu, Xiangxin 1; Wang, Yunqing2 ; Mei, Rongchao 3; Chong, Xiaomeng 4; Chen, Lingxin2 ; Ning, Baoming 4; Zhang, Rongqin 5; Zhuang, Xuming 1
发表期刊	ANALYTICAL METHODS
ISSN	1759-9660
	2024-09-21
页码	8
DOI	10.1039/d4ay01523a
通讯作者	Ning, Baoming() ; Zhang, Rongqin() ; Zhuang, Xuming()
英文摘要	Semi-solid preparations such as ointments, creams, gels, and pastes are common topical dosage forms with complex compositions and microstructures. pH is a critical quality attribute for semi-solid preparations, affecting properties such as particle size distribution, drug dissociation state, and rheological behavior. Currently, traditional pH electrode methods only provide an "average" pH for large-volume matrices, with low spatial resolution and accuracy. Microenvironment pH detection is crucial for accurately assessing semi-solid preparations. Herein, we developed pH-sensitive surface enhanced Raman scattering (SERS) microtips to achieve localized pH detection in semi-solid preparations. SERS microtips were prepared from glass needles with a tip size of around 1 mu m and gold nanoparticles (Au NPs) grown in situ on glass surfaces for SERS enhancement. 4-Mercaptopyridine was selected as a pH sensitive Raman reporter and immobilized on the Au NPs, exhibiting characteristic Raman peak shifts within the pH range of 3-10. The SERS microtips were employed to conduct highly sensitive pH measurements in localized areas of 15 commercial ointments, 8 gels, and 1 laboratory-made ointment, providing higher spatial resolution and microenvironment differentiation compared to pH meters. The SERS microtips were used to monitor pH changes over time in ointment applied to localized wounds on live mice. This work introduces a new tool for pH detection in semi-solid preparations, offering a new method to enhance the prescription process and quality assessment of complex preparations like topical semi-solid preparations. Microregion pH of semi-solid preparations such as ointments, creams, gels can be revealed by pH-sensitive surface enhanced Raman scattering microtips.
资助机构	SCMPA Key Laboratory for Quality Research and Control of Chemical Medicine ; Taishan Scholar Project Special Funding ; Special Fund for Leading Scholar Program of Yantai
收录类别	SCI
语种	英语
研究领域[WOS]	Chemistry ; Food Science & Technology ; Spectroscopy
WOS记录号	WOS:001327112500001
引用统计
文献类型	期刊论文
条目标识符	http://ir.yic.ac.cn/handle/133337/36513
专题	中国科学院海岸带环境过程与生态修复重点实验室中国科学院海岸带环境过程与生态修复重点实验室_海岸带环境工程技术研究与发展中心
通讯作者	Ning, Baoming; Zhang, Rongqin; Zhuang, Xuming
作者单位	1.Yantai Univ, Coll Chem & Chem Engn, Yantai 264005, Peoples R China 2.Chinese Acad Sci, CAS Key Lab Coastal Environm Proc & Ecol Remediat, Yantai Inst Coastal Zone Res, Yantai 264003, Peoples R China 3.Binzhou Med Univ, Sch Pharm, Yantai 264003, Peoples R China 4.Natl Inst Food & Drug Control, Key Lab Natl Med Prod Adm, Key Lab Res & Evaluat Chem Drug Qual, Beijing 102629, Peoples R China 5.SCMPA Key Lab Qual Res & Control Chem Med, Chengdu 610041, Peoples R China
推荐引用方式 GB/T 7714	Lu, Xiangxin,Wang, Yunqing,Mei, Rongchao,et al. Surface enhanced Raman scattering microtips for microenvironment pH determination of semi-solid preparations[J]. ANALYTICAL METHODS,2024:8.
APA	Lu, Xiangxin.,Wang, Yunqing.,Mei, Rongchao.,Chong, Xiaomeng.,Chen, Lingxin.,...&Zhuang, Xuming.(2024).Surface enhanced Raman scattering microtips for microenvironment pH determination of semi-solid preparations.ANALYTICAL METHODS,8.
MLA	Lu, Xiangxin,et al."Surface enhanced Raman scattering microtips for microenvironment pH determination of semi-solid preparations".ANALYTICAL METHODS (2024):8.