Triterpene Glycosides from the Viscera of Sea Cucumber <i>Apostichopus japonicus</i> with Embryotoxicity

doi:10.1002/cbdv.202400335

	*Triterpene Glycosides from the Viscera of Sea Cucumber Apostichopus japonicus* with Embryotoxicity**
	Liu, Yanfang 1,3; Lu, Zhen 1; Yan, Zhi 2; Li, Xiaodong 1; Yin, Xiuli1 ; Zhang, Ranran 1,3; Li, Yaxi 1; Wang, Song 4; Xie, Ruliang 4; Li, Ke1
发表期刊	CHEMISTRY & BIODIVERSITY
ISSN	1612-1872
	2024-03-29
页码	7
关键词	Saponin viscera holostane acute toxicity chemical defense
DOI	10.1002/cbdv.202400335
通讯作者	Li, Ke([email protected])
英文摘要	Sea cucumbers release chemical repellents from their guts when they are in danger from predators or a hostile environment. To investigate the chemical structure of the repellent, we collected and chemically analyzed the viscera of stressed sea cucumbers (Apostichopus japonicus) in the Yellow Sea of China. Two undescribed triterpene glycosides (1 and 2), together with a known cladoloside A (3), were identified and elucidated as 3 beta-O-{2-O-[beta-d-quinovopyranosyl]-4-O-[3-O-methyl-beta-d-glucopyranosyl-(1 -> 3)-beta-d-glucopyranosyl]-beta-d-xylopyranosyl}-holosta-9(11),25(26)-dien-16-one (1), 3 beta-O-{2-O-[beta-d-glucopyranosyl]-4-O-[3-O-methyl-beta-d-glucopyranosyl-(1 -> 3)-beta-d-glucopyranosyl]-beta-d-xylopyranosyl}-holosta-9(11),25(26)-dien-16-one (2), 3 beta-O-{2-O-[3-O-methyl-beta-d-glucopyranosyl-(1 -> 3)-beta-d-xylopyranosyl-(1 -> 4)-beta-d-quinovopyranosyl]-beta-d-xylopyranosyl}-holosta-9(11),25(26)-dien-16-one (3) by spectroscopic analysis, including HR-ESI-MS and NMR spectra. Compounds 1, 2, and 3 display embryonic toxicity, as indicated by their 96-hour post-fertilization lethal concentration (96 hpf-LC50) values of 0.289, 0.536, and 0.091 mu M, respectively. Our study discovered a class of triterpene glycoside compounds consisting of an oligosaccharide with four sugar units and a holostane aglycone. These compounds possess embryotoxicity and may serve as chemical defense molecules in marine benthic ecosystems.
资助机构	National Natural Science Foundation of China ; STS Program of CAS ; Yantai Science and Technology Innovation Development Program ; Priority Academic Program Development of Jiangsu Higher Education Institutions ; Taishan Scholar Program from Shandong Province of China ; Yantai Municipal City's Shuangbai Plan
收录类别	SCI
语种	英语
关键词[WOS]	OLIGOGLYCOSIDES ; EFFICIENCY
研究领域[WOS]	Biochemistry & Molecular Biology ; Chemistry
WOS记录号	WOS:001193765700001
引用统计
文献类型	期刊论文
条目标识符	http://ir.yic.ac.cn/handle/133337/36149
专题	海岸带生物学与生物资源利用重点实验室海岸带生物学与生物资源利用重点实验室_海岸带生物资源高效利用研究与发展中心
通讯作者	Li, Ke
作者单位	1.Chinese Acad Sci, Yantai Inst Coastal Zone Res, Yantai 264003, Peoples R China 2.Yantai Univ, Sch Ocean, Yantai 264005, Peoples R China 3.Univ Chinese Acad Sci, Beijing 100049, Peoples R China 4.Jiangsu Ocean Univ, Coinnovat Ctr Jiangsu Marine Bioind Technol, 59 Cangwu Rd, Lianyungang 222005, Peoples R China
推荐引用方式 GB/T 7714	Liu, Yanfang,Lu, Zhen,Yan, Zhi,et al. Triterpene Glycosides from the Viscera of Sea Cucumber Apostichopus japonicus with Embryotoxicity[J]. CHEMISTRY & BIODIVERSITY,2024:7.
APA	Liu, Yanfang.,Lu, Zhen.,Yan, Zhi.,Li, Xiaodong.,Yin, Xiuli.,...&Li, Ke.(2024).Triterpene Glycosides from the Viscera of Sea Cucumber Apostichopus japonicus with Embryotoxicity.CHEMISTRY & BIODIVERSITY,7.
MLA	Liu, Yanfang,et al."Triterpene Glycosides from the Viscera of Sea Cucumber Apostichopus japonicus with Embryotoxicity".CHEMISTRY & BIODIVERSITY (2024):7.