Imaging of carboxylesterase 2 expression changes in colitis and colon cancer chemotherapy via a fluorescent probe

doi:10.1016/j.snb.2024.135609

	Imaging of carboxylesterase 2 expression changes in colitis and colon cancer chemotherapy via a fluorescent probe
	Wang, Lingxiao 1; Wang, Lingyun 4; Sun, Xiao 1; Fu, Lili 1,2; Sun, Mingzhao 1; Wang, Xinlei 1; Wang, Xiaoyan 1,2; Chen, Lingxin2,3,5 ; Huang, Yan 1
发表期刊	SENSORS AND ACTUATORS B-CHEMICAL
	2024-06-15
卷号	409 页码:9
关键词	Carboxylesterase 2 Fluorescent probe Colitis Colon cancer Chemotherapy resistance
DOI	10.1016/j.snb.2024.135609
通讯作者	Chen, Lingxin([email protected]) ; Huang, Yan([email protected])
英文摘要	Colitis is one of the important etiologies of colon cancer, but the diagnosis of early colitis and colon cancer is still a difficult problem, so it is important to use reasonable methods to achieve the diagnosis of early colitis and colon cancer. Carboxylesterase 2 (CES2) is momentous in the development of colon disease and can be used as an indicator to distinguish colitis from colon cancer. CES2 is expressed differently in colitis and colon cancer, so it has the potential to distinguish colitis from colon cancer by detecting the difference in CES2 expression. We designed a fluorescent probe Bcy-CES2 for imaging CES2 in cells and in vivo and evaluating the differences in CES2 levels in colon disease. Probe Bcy-CES2 shows good potential for in situ real -time monitoring of endogenous CES2. In addition, we found that the combination of CES2 inhibitor BNPP and cisplatin can reduce tumor chemotherapy resistance, and CES2 levels may become a new index for early diagnosis and prognosis of colon cancer.
资助机构	National Nature Science Foundation of China ; Research Initiation Fund of Binzhou Medical University ; Taishan Scholar Project Special Funding ; Shandong Peninsula Engineering Research Center of Comprehensive Brine Utilization
收录类别	SCI
语种	英语
关键词[WOS]	COLORECTAL-CANCER ; CHEMORESISTANCE ; CELLS
研究领域[WOS]	Chemistry ; Electrochemistry ; Instruments & Instrumentation
WOS记录号	WOS:001211466100001
引用统计
文献类型	期刊论文
条目标识符	http://ir.yic.ac.cn/handle/133337/36091
专题	中国科学院海岸带环境过程与生态修复重点实验室中国科学院海岸带环境过程与生态修复重点实验室_海岸带环境工程技术研究与发展中心
通讯作者	Chen, Lingxin; Huang, Yan
作者单位	1.Binzhou Med Univ, Sch Pharm, Yantai 264003, Peoples R China 2.Chinese Acad Sci, Yantai Inst Coastal Zone Res, Shandong Res Ctr Coastal Environm Engn & Technol, CAS Key Lab Coastal Environm Proc & Ecol Remediat, Yantai 264003, Peoples R China 3.Qingdao Marine Sci & Technol Ctr, Lab Marine Biol & Biotechnol, Qingdao 266237, Peoples R China 4.Jinan Zhangqiu Dist Peoples Hosp, Jinan 250000, Peoples R China 5.Shaoxing Univ, Coll Chem & Chem Engn, Shaoxing 312000, Peoples R China
推荐引用方式 GB/T 7714	Wang, Lingxiao,Wang, Lingyun,Sun, Xiao,et al. Imaging of carboxylesterase 2 expression changes in colitis and colon cancer chemotherapy via a fluorescent probe[J]. SENSORS AND ACTUATORS B-CHEMICAL,2024,409:9.
APA	Wang, Lingxiao.,Wang, Lingyun.,Sun, Xiao.,Fu, Lili.,Sun, Mingzhao.,...&Huang, Yan.(2024).Imaging of carboxylesterase 2 expression changes in colitis and colon cancer chemotherapy via a fluorescent probe.SENSORS AND ACTUATORS B-CHEMICAL,409,9.
MLA	Wang, Lingxiao,et al."Imaging of carboxylesterase 2 expression changes in colitis and colon cancer chemotherapy via a fluorescent probe".SENSORS AND ACTUATORS B-CHEMICAL 409(2024):9.