Polyhydroxy steroids isolated from starfish (<i>Asterina pectinifera</i>) and their embryotoxicity

doi:10.1080/14786419.2024.2350639

	*Polyhydroxy steroids isolated from starfish (Asterina pectinifera) and their embryotoxicity*
	Zhang, Ranran 1,2; Lu, Zhen 1; Wang, Derui 1,3; Yan, Zhi 1,4; Sun, Xueting 1; Li, Xiaodong 1; Yin, Xiuli1 ; Li, Ke1
发表期刊	NATURAL PRODUCT RESEARCH
ISSN	1478-6419
	2024-05-02
页码	7
关键词	Polyhydroxy steroids embryotoxicity starfish Asterina pectinifera
DOI	10.1080/14786419.2024.2350639
通讯作者	Li, Ke([email protected])
英文摘要	Many marine organisms possess an essential capacity to produce secondary metabolites that exhibit toxic characteristics. A new polyhydroxy steroid, 24-methyl-5 alpha-cholestane-24(28)-ene-3 beta, 4 beta, 6 alpha, 7 alpha, 8, 15 beta, 16 beta, 26-octol-6-O-sodium sulphate (1) was isolated from starfish (Asterina pectinifera), along with five polar steroid compounds (2-6) that were previously identified. NMR (H-1 and C-13 NMR, H-1-H-1 COSY, HSQC, HMBC, and NOESY) and HR-ESI-MS were employed for structure elucidations. The embryotoxicity and teratogenicity of the isolated compounds were assessed using embryos of marine medaka (Oryzias melastigma). Compound 5 exhibited moderate embryotoxicity (96h-LC50: 65 mu M). [Graphical Abstract]
资助机构	National Natural Science Foundation of China ; Taishan Scholar Program from Shandong Province of China ; Shuangbai Plan ; Yantai Municipal City's
收录类别	SCI
语种	英语
研究领域[WOS]	Chemistry ; Pharmacology & Pharmacy
WOS记录号	WOS:001219554600001
引用统计
文献类型	期刊论文
条目标识符	http://ir.yic.ac.cn/handle/133337/36057
专题	海岸带生物学与生物资源利用重点实验室海岸带生物学与生物资源利用重点实验室_海岸带生物资源高效利用研究与发展中心
通讯作者	Li, Ke
作者单位	1.Chinese Acad Sci, Yantai Inst Coastal Zone Res, Yantai, Peoples R China 2.Univ Chinese Acad Sci, Coll Resources & Environm, Beijing, Peoples R China 3.Beibu Gulf Univ, Coll Marine Sci, Qinzhou, Peoples R China 4.Yantai Univ, Sch Ocean, Yantai, Peoples R China
推荐引用方式 GB/T 7714	Zhang, Ranran,Lu, Zhen,Wang, Derui,et al. Polyhydroxy steroids isolated from starfish (Asterina pectinifera) and their embryotoxicity[J]. NATURAL PRODUCT RESEARCH,2024:7.
APA	Zhang, Ranran.,Lu, Zhen.,Wang, Derui.,Yan, Zhi.,Sun, Xueting.,...&Li, Ke.(2024).Polyhydroxy steroids isolated from starfish (Asterina pectinifera) and their embryotoxicity.NATURAL PRODUCT RESEARCH,7.
MLA	Zhang, Ranran,et al."Polyhydroxy steroids isolated from starfish (Asterina pectinifera) and their embryotoxicity".NATURAL PRODUCT RESEARCH (2024):7.