Hydrogel-Coated SERS Microneedles for Drug Monitoring in Dermal Interstitial Fluid

doi:10.1021/acssensors.4c00276

	Hydrogel-Coated SERS Microneedles for Drug Monitoring in Dermal Interstitial Fluid
	Li, Yan1,2 ; Wang, Yunqing2 ; Mei, Rongchao 3; Lv, Bingqian 1; Zhao, Xizhen 4; Bi, Liyan 3; Xu, Hui 1; Chen, Lingxin2,5
发表期刊	ACS SENSORS
ISSN	2379-3694
	2024-05-02
卷号	9 期号:5 页码:2567-2574
关键词	surface-enhanced Raman spectroscopy microneedles interstitial fluid drug detection point-of-caretesting
DOI	10.1021/acssensors.4c00276
通讯作者	Wang, Yunqing([email protected]) ; Xu, Hui([email protected]) ; Chen, Lingxin([email protected])
英文摘要	In vivo drug monitoring is crucial for evaluating the effectiveness and safety of drug treatment. Blood sampling and analysis is the current gold standard but needs professional skills and cannot meet the requirements of point-of-care testing. Dermal interstitial fluid (ISF) showed great potential to replace blood for in vivo drug monitoring; however, the detection was challenging, and the drug distribution behavior in ISF was still unclear until now. In this study, we proposed surface-enhanced Raman spectroscopy (SERS) microneedles (MNs) for the painless and real-time analysis of drugs in ISF after intravenous injection. Using methylene blue (MB) and mitoxantrone (MTO) as model drugs, the innovative core-satellite structured Au@Ag SERS substrate, hydrogel coating over the MNs, rendered sensitive and quantitative drug detection in ISF of mice within 10 min. Based on this technique, the pharmacokinetics of the two drugs in ISF was investigated and compared with those in blood, where the drugs were analyzed via liquid chromatography-mass spectrometry. It was found that the MB concentration in ISF and blood was comparable, whereas the concentration of MTO in ISF was 2-3 orders of magnitude lower than in blood. This work proposed an efficient tool for ISF drug monitoring. More importantly, it experimentally proved that the penetration ratio of blood to ISF was drug-dependent, providing insightful information into the potential of ISF as a blood alternative for in vivo drug detection.
资助机构	National Natural Science Foundation of China ; National Natural Science Foundation of China ; Shandong Science and Technology Foundation ; Instrument Developing Project of the Chinese Academy of Sciences ; Taishan Scholar Project Special Funding ; Special Fund for Leading Scholar Program of Yantai
收录类别	SCI
语种	英语
关键词[WOS]	QUANTIFICATION
研究领域[WOS]	Chemistry ; Science & Technology - Other Topics
WOS记录号	WOS:001225416200001
引用统计
文献类型	期刊论文
条目标识符	http://ir.yic.ac.cn/handle/133337/36051
专题	中国科学院海岸带环境过程与生态修复重点实验室中国科学院海岸带环境过程与生态修复重点实验室_海岸带环境工程技术研究与发展中心
通讯作者	Wang, Yunqing; Xu, Hui; Chen, Lingxin
作者单位	1.Yantai Univ, Collaborat Innovat Ctr Adv Drug Delivery Syst & Bi, Sch Pharm, Key Lab Mol Pharmacol & Drug Evaluat,Minist Educ, Yantai 264005, Peoples R China 2.Chinese Acad Sci, CAS Key Lab Coastal Environm Proc & Ecol Remediat, Yantai Inst Coastal Zone Res, Yantai 264003, Peoples R China 3.Binzhou Med Univ, Sch Pharm, Yantai 264003, Peoples R China 4.Univ Chinese Acad Sci, Beijing 100049, Peoples R China 5.Qingdao Marine Sci & Technol Ctr, Lab Marine Biol & Biotechnol, Qingdao 266237, Peoples R China
推荐引用方式 GB/T 7714	Li, Yan,Wang, Yunqing,Mei, Rongchao,et al. Hydrogel-Coated SERS Microneedles for Drug Monitoring in Dermal Interstitial Fluid[J]. ACS SENSORS,2024,9(5):2567-2574.
APA	Li, Yan.,Wang, Yunqing.,Mei, Rongchao.,Lv, Bingqian.,Zhao, Xizhen.,...&Chen, Lingxin.(2024).Hydrogel-Coated SERS Microneedles for Drug Monitoring in Dermal Interstitial Fluid.ACS SENSORS,9(5),2567-2574.
MLA	Li, Yan,et al."Hydrogel-Coated SERS Microneedles for Drug Monitoring in Dermal Interstitial Fluid".ACS SENSORS 9.5(2024):2567-2574.