Time Is Ripe for Targeting Per- and Polyfluoroalkyl Substances-Induced Hormesis: Global Aquatic Hotspots and Implications for Ecological Risk Assessment

doi:10.1021/acs.est.4c00686

	Time Is Ripe for Targeting Per- and Polyfluoroalkyl Substances-Induced Hormesis: Global Aquatic Hotspots and Implications for Ecological Risk Assessment
	Sun, Tao 1,2,3; Ji, Chenglong1,2,4,5 ; Li, Fei1,2,5 ; Wu, Huifeng1,2,4,5
发表期刊	ENVIRONMENTAL SCIENCE & TECHNOLOGY
ISSN	0013-936X
	2024-05-06
卷号	58 期号:21 页码:9314-9327
关键词	per- and polyfluoroalkyl substances (PFAS) risk assessment subthreshold effect hormesis biological plasticity
DOI	10.1021/acs.est.4c00686
通讯作者	Wu, Huifeng([email protected])
英文摘要	Globally implemented ecological risk assessment (ERA) guidelines marginalize hormesis, a biphasic dose-response relationship characterized by low-dose stimulation and high-dose inhibition. The present study illuminated the promise of hormesis as a scientific dose-response model for ERA of per- and polyfluoroalkyl substances (PFAS) represented by perfluorooctanoic acid (PFOA) and perfluorooctanesulfonic acid (PFOS). A total of 266 hormetic dose-response relationships were recompiled from 1237 observations, covering 30 species from nine representative taxonomic groups. The standardized hormetic amplitudes followed the log-normal probability distribution, being subject to the limits of biological plasticity but independent of stress inducers. The SHapley Additive exPlanations algorithm revealed that the target endpoint was the most important variable explaining the hormetic amplitudes. Subsequently, quantitative frameworks were established to incorporate hormesis into the predicted no-effect concentration levels, with a lower induction dose and a zero-equivalent point but a broader hormetic zone for PFOS. Realistically, 10,117 observed concentrations of PFOA and PFOS were gathered worldwide, 4% of which fell within hormetic zones, highlighting the environmental relevance of hormesis. Additionally, the hormesis induction potential was identified in other legacy and emerging PFAS as well as their alternatives and mixtures. Collectively, it is time to incorporate the hormesis concept into PFAS studies to facilitate more realistic risk characterizations.
资助机构	Key Technology Research and Development Program of Shandong Province ; Key R&D Program of Shandong Province, China ; National Natural Science Foundation of China ; Young Taishan Scholars Program of Shandong Province
收录类别	SCI
语种	英语
关键词[WOS]	HORMETIC DOSE RESPONSES ; PERFLUOROOCTANE SULFONATE ; SURFACE-WATER ; TOXICITY ; PFOA ; METAANALYSIS ; HOMEOSTASIS ; EXPOSURE ; DAMAGE ; PFASS
研究领域[WOS]	Engineering ; Environmental Sciences & Ecology
WOS记录号	WOS:001225120100001
引用统计	被引频次：2[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	http://ir.yic.ac.cn/handle/133337/36048
专题	中国科学院海岸带环境过程与生态修复重点实验室中国科学院海岸带环境过程与生态修复重点实验室_海岸带环境过程实验室
通讯作者	Wu, Huifeng
作者单位	1.Chinese Acad Sci, Yantai Inst Coastal Zone Res YIC, CAS Key Lab Coastal Environm Proc & Ecol Remediat, Yantai 264003, Peoples R China 2.YICCAS, Shandong Key Lab Coastal Environm Proc, Yantai 264003, Peoples R China 3.Univ Chinese Acad Sci, Beijing 100049, Peoples R China 4.Laoshan Lab, Funct Lab Marine Fisheries Sci & Food Prod Proc, Qingdao 266237, Peoples R China 5.Chinese Acad Sci, Ctr Ocean Mega Sci, Qingdao 266071, Peoples R China
推荐引用方式 GB/T 7714	Sun, Tao,Ji, Chenglong,Li, Fei,et al. Time Is Ripe for Targeting Per- and Polyfluoroalkyl Substances-Induced Hormesis: Global Aquatic Hotspots and Implications for Ecological Risk Assessment[J]. ENVIRONMENTAL SCIENCE & TECHNOLOGY,2024,58(21):9314-9327.
APA	Sun, Tao,Ji, Chenglong,Li, Fei,&Wu, Huifeng.(2024).Time Is Ripe for Targeting Per- and Polyfluoroalkyl Substances-Induced Hormesis: Global Aquatic Hotspots and Implications for Ecological Risk Assessment.ENVIRONMENTAL SCIENCE & TECHNOLOGY,58(21),9314-9327.
MLA	Sun, Tao,et al."Time Is Ripe for Targeting Per- and Polyfluoroalkyl Substances-Induced Hormesis: Global Aquatic Hotspots and Implications for Ecological Risk Assessment".ENVIRONMENTAL SCIENCE & TECHNOLOGY 58.21(2024):9314-9327.