Epidermal oxysterols function as alarm substances in zebrafish

doi:10.1016/j.isci.2024.109660

	Epidermal oxysterols function as alarm substances in zebrafish
	Li, Yaxi 1,2; Yan, Zhi 1,3; Lin, Ainuo 1,2; Yang, Xiao 1,2; Li, Xiaodong 1; Yin, Xiuli1 ; Li, Weiming 4; Li, Ke1,5
发表期刊	ISCIENCE
	2024-05-17
卷号	27 期号:5 页码:16
DOI	10.1016/j.isci.2024.109660
通讯作者	Li, Ke([email protected])
英文摘要	Alarm substances signal imminent predation thread and enable anti -predation strategies. In shoaling fish, alarm cues diffuse from injured skins that induce intense fear and anti -predation behaviors in other members. While these "fear substances"are shown to be present in numerous fishes and thought to exist in roughly 8,000 Ostariophysan species, their chemical nature remains largely unknown. We posited that fish alarm cues comprise small compounds and induce specific behaviors characteristic of fish exposed to skin extracts. Using the behaviors as bioassays, we tracked the alarm function of zebrafish skin extract to two compounds, 24-methyl-5 a- cholestane-3 a, 7 a, 12 a, 24,28-pentahydroxy 28 -sulfate, an oxysterol sulfate, and 5 a- cyprinol sulfate. At concentrations of less than one nanomolar, each compound induced antipredator behaviors and increased cortisol levels in zebrafish. Their mixture, at the natural ratio, replicated the skin extract in eliciting the full suite of anti -predator behavior patterns. Our findings reveal a molecular mechanism whereby fish escape predation danger.
资助机构	National Natural Science Foundation of China ; Yantai Institute of Coastal Zone Research, Chinese Academy of Sciences ; Shandong Province of China ; Yantai Municipal City's Shuangbai Plan ; Great Lakes Fishery Commission
收录类别	SCI
语种	英语
关键词[WOS]	DANIO-RERIO ; BILE-SALTS ; CHOLESTEROL-METABOLISM ; BEHAVIORAL-RESPONSES ; CYPRINOL SULFATE ; MODEL ORGANISM ; PREY ; FEAR ; QUANTIFICATION ; OSTARIOPHYSI
研究领域[WOS]	Science & Technology - Other Topics
WOS记录号	WOS:001230313400001
引用统计
文献类型	期刊论文
条目标识符	http://ir.yic.ac.cn/handle/133337/36036
专题	海岸带生物学与生物资源利用重点实验室海岸带生物学与生物资源利用重点实验室_海岸带生物资源高效利用研究与发展中心
通讯作者	Li, Ke
作者单位	1.Chinese Acad Sci, Yantai Inst Coastal Zone Res, Yantai 264003, Peoples R China 2.Univ Chinese Acad Sci, Coll Resources & Environm, Beijing 100049, Peoples R China 3.Yantai Univ, Sch Ocean, Yantai 264005, Peoples R China 4.Michigan State Univ, Dept Fisheries & Wildlife, Lansing, MI 48824 USA 5.Chinese Acad Sci, Ctr Ocean Mega Sci, Qingdao 266071, Peoples R China
推荐引用方式 GB/T 7714	Li, Yaxi,Yan, Zhi,Lin, Ainuo,et al. Epidermal oxysterols function as alarm substances in zebrafish[J]. ISCIENCE,2024,27(5):16.
APA	Li, Yaxi.,Yan, Zhi.,Lin, Ainuo.,Yang, Xiao.,Li, Xiaodong.,...&Li, Ke.(2024).Epidermal oxysterols function as alarm substances in zebrafish.ISCIENCE,27(5),16.
MLA	Li, Yaxi,et al."Epidermal oxysterols function as alarm substances in zebrafish".ISCIENCE 27.5(2024):16.