Synthesis, antimicrobial activity, antioxidant activity and molecular docking of novel chitosan derivatives containing glycine Schiff bases as potential succinate dehydrogenase inhibitors

doi:10.1016/j.ijbiomac.2024.131407

	Synthesis, antimicrobial activity, antioxidant activity and molecular docking of novel chitosan derivatives containing glycine Schiff bases as potential succinate dehydrogenase inhibitors
	Cui, Jingmin 1,2,3; Wang, Yanqing 4; Liang, Xiaorui 5; Zhao, Jinyu 6; Ji, Yuting 1,2,3; Tan, Wenqiang1,2 ; Dong, Fang1,2 ; Guo, Zhanyong1,2,3
发表期刊	INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
ISSN	0141-8130
	2024-05-01
卷号	267 页码:12
关键词	Chitosan Schiff bases Succinate dehydrogenase
DOI	10.1016/j.ijbiomac.2024.131407
通讯作者	Dong, Fang([email protected]) ; Guo, Zhanyong([email protected])
英文摘要	Succinate dehydrogenase (SDH) is an important inner mitochondrial membrane-bound enzyme involved in redox reactions during the tricarboxylic acid cycle. Therefore, a series of novel chitosan derivatives were designed and synthesized as potential microbicides targeting SDH and precisely characterized by FTIR, 1 H NMR and SEM. Their antifungal and antibacterial activities were evaluated against Botrytis cinerea , Fusarium graminearum , Staphylococcus aureus and Escherichia coli . The bioassays revealed that these chitosan derivatives exerted significant antifungal effects, with four of the compounds achieving 100 % inhibition of Fusarium graminearum merely at a concentration of 0.5 mg/mL. Additionally, CSGDCH showed 79.34 % inhibition of Botrytis cinerea at a concentration of 0.1 mg/mL. In vitro antibacterial tests revealed that CSGDCH and CSGDBH have excellent Staphylococcus aureus and Escherichia coli inhibition with MICs of 0.0156 mg/mL and 0.03125 mg/mL, respectively. Molecular docking studies have been carried out to explore the binding energy and binding mode of chitosan and chitosan derivatives with SDH. The analyses indicated that chitosan derivatives targeted the active site of the SDH protein more precisely, disrupting its normal function and ultimately repressing the growth of microbial cells. Furthermore, the chitosan derivatives were also evaluated biologically for antioxidation, and all of these compounds had a greater degree of reducing power, superoxide radical, hydroxyl radical and DPPHradical scavenging activity than chitosan. This research has the potential for the development of agricultural antimicrobial agents.
资助机构	Science & Technology Specific Projects in Agricultural High-tech Industrial Demonstration Area of the Yellow River Delta ; The 2022 Central Guiding Local Science and Technology Development Fund Project in Shandong Province ; Major Scientific and Technological Innovation Project ; Youth Innovation Promotion Association CAS ; Key Research & Development Plan of Shandong Province
收录类别	SCI
语种	英语
关键词[WOS]	BIOLOGICAL-ACTIVITY ; COMPLEX-II ; MECHANISM ; DISEASES ; DESIGN ; COPPER
研究领域[WOS]	Biochemistry & Molecular Biology ; Chemistry ; Polymer Science
WOS记录号	WOS:001229623900001
引用统计	被引频次：4[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	http://ir.yic.ac.cn/handle/133337/36011
专题	海岸带生物学与生物资源利用重点实验室海岸带生物学与生物资源利用重点实验室_海岸带生物资源高效利用研究与发展中心
通讯作者	Dong, Fang; Guo, Zhanyong
作者单位	1.Chinese Acad Sci, Key Lab Coastal Biol & Bioresource Utilizat, Yantai Inst Coastal Zone Res, Yantai 264003, Peoples R China 2.Chinese Acad Sci, Ctr Ocean Mega Sci, 7 Nanhai Rd, Qingdao 266071, Peoples R China 3.Univ Chinese Acad Sci, Beijing 100049, Peoples R China 4.Ocean Univ China, Sch Med & Pharm, Key Lab Marine Drugs, Minist Educ, Qingdao 266003, Peoples R China 5.Naval Aviat Univ, Sch Basic Sci Aviat, Yantai 264001, Peoples R China 6.Yantai Univ, Sch Chem & Chem Engn, Yantai 264005, Peoples R China
推荐引用方式 GB/T 7714	Cui, Jingmin,Wang, Yanqing,Liang, Xiaorui,et al. Synthesis, antimicrobial activity, antioxidant activity and molecular docking of novel chitosan derivatives containing glycine Schiff bases as potential succinate dehydrogenase inhibitors[J]. INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES,2024,267:12.
APA	Cui, Jingmin.,Wang, Yanqing.,Liang, Xiaorui.,Zhao, Jinyu.,Ji, Yuting.,...&Guo, Zhanyong.(2024).Synthesis, antimicrobial activity, antioxidant activity and molecular docking of novel chitosan derivatives containing glycine Schiff bases as potential succinate dehydrogenase inhibitors.INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES,267,12.
MLA	Cui, Jingmin,et al."Synthesis, antimicrobial activity, antioxidant activity and molecular docking of novel chitosan derivatives containing glycine Schiff bases as potential succinate dehydrogenase inhibitors".INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES 267(2024):12.