Inflammatory bowel disease alters in vivo distribution of orally administrated nanoparticles: Revealing via SERS tag labeling technique

doi:10.1016/j.talanta.2024.126172

	Inflammatory bowel disease alters in vivo distribution of orally administrated nanoparticles: Revealing via SERS tag labeling technique
	Tan, Mingyue 1; Wang, Yunqing2 ; Ji, Yunxia 1; Mei, Rongchao 1; Zhao, Xizhen 2,5; Song, Jie 1; You, Jinmao 4; Chen, Lingxin2,3,4 ; Wang, Xiaoyan 1
发表期刊	TALANTA
ISSN	0039-9140
	2024-08-01
卷号	275 页码:9
关键词	Surface-enhanced Raman scattering SERS tag Inflammatory bowel disease Nanoparticles In vivo
DOI	10.1016/j.talanta.2024.126172
通讯作者	Wang, Yunqing([email protected]) ; Chen, Lingxin([email protected]) ; Wang, Xiaoyan([email protected])
英文摘要	Nanoparticles (NPs) could be uptake orally and exposed to digestive tract through various sources such as particulate pollutant, nanomedicine and food additive. Inflammatory bowel disease (IBD), as a global disease, induced disruption of the intestinal mucosal barrier and thus altered in vivo distribution of NPs as a possible consequence. However, related information was relatively scarce. Herein, in vivo distribution of typical silica (SiO 2 ) and titania (TiO 2 ) NPs was investigated in healthy and IBD models at cell and animal levels via a surfaceenhanced Raman scattering (SERS) tag labeling technique. The labeled NPs were composed of gold SERS tag core and SiO 2 (or TiO 2 ) shell, demonstrating sensitive and characteristic SERS signals ideal to trace the NPs in vivo . Cell SERS mapping revealed that protein corona from IBD intestinal fluid decreased uptake of NPs by lipopolysaccharide-induced RAW264.7 cells compared with normal intestinal fluid protein corona. SERS signal detection combined with inductively coupled plasma mass spectrometry (ICP-MS) analysis of mouse tissues (heart, liver, spleen, lung and kidney) indicated that both NPs tended to accumulate in lung specifically after oral administration for IBD mouse (6 out of 20 mice for SiO 2 and 4 out of 16 mice for TiO 2 were detected in lung). Comparatively, no NP signals were detected in all tissues from healthy mice. These findings suggested that there might be a greater risk associated with the oral uptake of NPs in IBD patients due to altered in vivo distribution of NPs.
资助机构	Foundation of China ; Instrument Developing Project of the Chinese Academy of Sciences ; Taishan Scholar Project Special Funding ; Special Fund for Leading Scholar Program of Yantai
收录类别	SCI
语种	英语
关键词[WOS]	M-CELLS ; EPIDEMIOLOGY ; ABSORPTION ; INTESTINE ; TRANSPORT
研究领域[WOS]	Chemistry
WOS记录号	WOS:001235885700001
引用统计	被引频次：1[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	http://ir.yic.ac.cn/handle/133337/35981
专题	中国科学院海岸带环境过程与生态修复重点实验室中国科学院海岸带环境过程与生态修复重点实验室_海岸带环境工程技术研究与发展中心
通讯作者	Wang, Yunqing; Chen, Lingxin; Wang, Xiaoyan
作者单位	1.Binzhou Med Univ, Sch Pharm, Yantai 264003, Peoples R China 2.Chinese Acad Sci, CAS Key Lab Coastal Environm Proc & Ecol Remediat, Yantai Inst Coastal Zone Res, Yantai 264003, Peoples R China 3.Qingdao Marine Sci & Technol Ctr, Lab Marine Biol & Biotechnol, Qingdao 266237, Peoples R China 4.Shaoxing Univ, Coll Chem & Chem Engn, Shaoxing 312000, Peoples R China 5.Univ Chinese Acad Sci, Beijing 100049, Peoples R China
推荐引用方式 GB/T 7714	Tan, Mingyue,Wang, Yunqing,Ji, Yunxia,et al. Inflammatory bowel disease alters in vivo distribution of orally administrated nanoparticles: Revealing via SERS tag labeling technique[J]. TALANTA,2024,275:9.
APA	Tan, Mingyue.,Wang, Yunqing.,Ji, Yunxia.,Mei, Rongchao.,Zhao, Xizhen.,...&Wang, Xiaoyan.(2024).Inflammatory bowel disease alters in vivo distribution of orally administrated nanoparticles: Revealing via SERS tag labeling technique.TALANTA,275,9.
MLA	Tan, Mingyue,et al."Inflammatory bowel disease alters in vivo distribution of orally administrated nanoparticles: Revealing via SERS tag labeling technique".TALANTA 275(2024):9.