Low molecular weight chitosan based GSH-responsive self-assembled cationic micelle with enhanced anti-tumor effect by combining oxidative damage and chemotherapy

doi:10.1016/j.ijbiomac.2024.131736

	Low molecular weight chitosan based GSH-responsive self-assembled cationic micelle with enhanced anti-tumor effect by combining oxidative damage and chemotherapy
	Yuan, Yuting 1,2,3; Chen, Qiuhong 1,3; Wang, Zhenhua 4; Mi, Yingqi 1,3; Dong, Fang1,2,3 ; Tan, Wenqiang1,2,3 ; Guo, Zhanyong1,2,3
发表期刊	INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
ISSN	0141-8130
	2024-05-01
卷号	268 页码:12
关键词	Amphiphilic conjugate GSH-responsive cationic micelle Low molecular weight chitosan
DOI	10.1016/j.ijbiomac.2024.131736
通讯作者	Tan, Wenqiang([email protected]) ; Guo, Zhanyong([email protected])
英文摘要	A novel cationic lipoic acid grafted low molecular weight chitosan (LCNE-LA) conjugate was constructed and further self-assembled into GSH-responsive cationic nanocarrier to achieve better antitumor effect by combining encapsulated chemotherapy and oxidative damage induced by ROS. The resultant LCNE-LA cationic micelle exhibited favorable physicochemical properties (low CMC, small size, positively zeta potential and good stability), excellent biosafety and desired redox sensitivity. Next, doxorubicin (Dox) was embedded into hydrophobic core to form stable Dox/LCNE-LA micelle that had superior loading capacity. The GSH-induced release behavior, cellular uptake ability, ROS generation and GSH consumption capacity and in vitro antitumor activity of Dox/LCNE-LA micelle were systematically evaluated. Consequently, Dox/LCNE-LA cationic micelle with positively charged could efficiently enter into cancer cell and redox-sensitive release Dox via disulfide-thiol exchange reaction, which usually expend abundant GSH and disrupt redox homeostasis. Studies further confirmed that Dox/LCNE-LA micelle could increase ROS and reduced GSH content which might cause oxidative damage to tumor cell. Antitumor activity indicated that Dox/LCNE-LA micelle achieved an excellent cancerkilling effect, which might be attributed to combination treatment of Dox and ROS induce oxidative damage. Overall, this research was expected to provide a platform for antitumor treatment by triggering Dox release and promoting ROS generation.
资助机构	Youth Innovation Promotion Association CAS ; Natural Science Foundation of Shandong Province of China ; Shandong Key R & D plan, Major Scientific and Technological Innovation Project
收录类别	SCI
语种	英语
关键词[WOS]	ANTIBACTERIAL ; CELLULOSE ; DELIVERY ; THERAPY ; RELEASE
研究领域[WOS]	Biochemistry & Molecular Biology ; Chemistry ; Polymer Science
WOS记录号	WOS:001236346800001
引用统计	被引频次：1[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	http://ir.yic.ac.cn/handle/133337/35978
专题	海岸带生物学与生物资源利用重点实验室海岸带生物学与生物资源利用重点实验室_海岸带生物资源高效利用研究与发展中心
通讯作者	Tan, Wenqiang; Guo, Zhanyong
作者单位	1.Yantai Inst Coastal Zone Res, Chinese Acad Sci, Key Lab Coastal Biol & Bioresource Utilizat, Yantai 264003, Peoples R China 2.Univ Chinese Acad Sci, Beijing 100049, Peoples R China 3.Chinese Acad Sci, Ctr Ocean Mega Sci, Qingdao 266071, Peoples R China 4.Yantai Univ, Coll Life Sci, Yantai 264005, Peoples R China
推荐引用方式 GB/T 7714	Yuan, Yuting,Chen, Qiuhong,Wang, Zhenhua,et al. Low molecular weight chitosan based GSH-responsive self-assembled cationic micelle with enhanced anti-tumor effect by combining oxidative damage and chemotherapy[J]. INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES,2024,268:12.
APA	Yuan, Yuting.,Chen, Qiuhong.,Wang, Zhenhua.,Mi, Yingqi.,Dong, Fang.,...&Guo, Zhanyong.(2024).Low molecular weight chitosan based GSH-responsive self-assembled cationic micelle with enhanced anti-tumor effect by combining oxidative damage and chemotherapy.INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES,268,12.
MLA	Yuan, Yuting,et al."Low molecular weight chitosan based GSH-responsive self-assembled cationic micelle with enhanced anti-tumor effect by combining oxidative damage and chemotherapy".INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES 268(2024):12.