Chronopotentiometric Nanopore Sensor Based on a Stimulus-Responsive Molecularly Imprinted Polymer for Label-Free Dual-Biomarker Detection

doi:10.1021/acs.analchem.3c05817

	Chronopotentiometric Nanopore Sensor Based on a Stimulus-Responsive Molecularly Imprinted Polymer for Label-Free Dual-Biomarker Detection
	Wang, Junhao 1,2,3; Zhou, Huihui 4; Liang, Rongning1,2 ; Qin, Wei1,2,5,6
发表期刊	ANALYTICAL CHEMISTRY
ISSN	0003-2700
	2024-04-29
卷号	96 期号:23 页码:9370-9378
DOI	10.1021/acs.analchem.3c05817
通讯作者	Liang, Rongning([email protected]) ; Qin, Wei([email protected])
英文摘要	The development of sensors for detection of biomarkers exhibits an exciting potential in diagnosis of diseases. Herein, we propose a novel electrochemical sensing strategy for label-free dual-biomarker detection, which is based on the combination of stimulus-responsive molecularly imprinted polymer (MIP)-modified nanopores and a polymeric membrane chronopotentiometric sensor. The ion fluxes galvanostatically imposed on the sensing membrane surface can be blocked by the recognition reaction between the target biomarker in the sample solution and the stimulus-responsive MIP receptor in the nanopores, thus causing a potential change. By using two external stimuli (i.e., pH and temperature), the recognition abilities of the stimulus-responsive MIP receptor can be effectively modulated so that dual-biomarker label-free chronopotentiometric detection can be achieved. Using alpha fetoprotein (AFP) and prostate-specific antigen (PSA) as model biomarkers, the proposed sensor offers detection limits of 0.17 and 0.42 ng/mL for AFP and PSA, respectively.
资助机构	Key Technology Research and Development Program of Shandong Province ; National Natural Science Foundation of China ; Key R&D Program of Shandong Province ; Key Deployment Project of Centre for Ocean Mega-Research of Science, Chinese Academy of Sciences ; Taishan Scholar Program of Shandong Province
收录类别	SCI
语种	英语
关键词[WOS]	DETECTION LIMIT ; MEMBRANE ELECTRODES ; ION FLUXES ; SURFACE ; GLYCOPROTEINS ; RECOGNITION ; MODULATION ; NANOSENSOR ; BIOSENSOR ; ANTIGEN
研究领域[WOS]	Chemistry
WOS记录号	WOS:001241271300001
引用统计
文献类型	期刊论文
条目标识符	http://ir.yic.ac.cn/handle/133337/35972
专题	中国科学院海岸带环境过程与生态修复重点实验室中国科学院海岸带环境过程与生态修复重点实验室_海岸带环境过程实验室
通讯作者	Liang, Rongning; Qin, Wei
作者单位	1.Chinese Acad Sci, Yantai Inst Coastal Zone Res YIC, CAS Key Lab Coastal Environm Proc & Ecol Remediat, Yantai 264003, Shandong, Peoples R China 2.YICCAS, Shandong Key Lab Coastal Environm Proc, Yantai 264003, Shandong, Peoples R China 3.Univ Chinese Acad Sci, Beijing 100049, Peoples R China 4.Qingdao Univ, Affiliated Yantai Yuhuangding Hosp, Yantai 264099, Shandong, Peoples R China 5.Qingdao Natl Lab Marine Sci & Technol, Lab Marine Biol & Biotechnol, Qingdao 266237, Shandong, Peoples R China 6.Chinese Acad Sci, Ctr Ocean Mega Sci, Qingdao 266071, Shandong, Peoples R China
推荐引用方式 GB/T 7714	Wang, Junhao,Zhou, Huihui,Liang, Rongning,et al. Chronopotentiometric Nanopore Sensor Based on a Stimulus-Responsive Molecularly Imprinted Polymer for Label-Free Dual-Biomarker Detection[J]. ANALYTICAL CHEMISTRY,2024,96(23):9370-9378.
APA	Wang, Junhao,Zhou, Huihui,Liang, Rongning,&Qin, Wei.(2024).Chronopotentiometric Nanopore Sensor Based on a Stimulus-Responsive Molecularly Imprinted Polymer for Label-Free Dual-Biomarker Detection.ANALYTICAL CHEMISTRY,96(23),9370-9378.
MLA	Wang, Junhao,et al."Chronopotentiometric Nanopore Sensor Based on a Stimulus-Responsive Molecularly Imprinted Polymer for Label-Free Dual-Biomarker Detection".ANALYTICAL CHEMISTRY 96.23(2024):9370-9378.