Molecularly imprinted polymer-coated silica microbeads for high-performance liquid chromatography

doi:10.1039/d4an00239c

	Molecularly imprinted polymer-coated silica microbeads for high-performance liquid chromatography
	Wu, Wenpu 1; Yu, Cuichi 1; Sui, Lei 1; Xu, Hui 1; Li, Jinhua2 ; Zhou, Na 2; Chen, Lingxin2,3 ; Song, Zhihua 1
发表期刊	ANALYST
ISSN	0003-2654
	2024-05-31
页码	8
DOI	10.1039/d4an00239c
通讯作者	Xu, Hui([email protected]) ; Chen, Lingxin([email protected]) ; Song, Zhihua([email protected])
英文摘要	Molecularly imprinted polymer (MIP)-based chromatographic separation materials, owing to their advantages of unique selectivity, low cost, suitable reproducibility, and acceptable stability, have attracted a great deal of research in different fields. In this investigation, a new type of MIP-coated silica (MIP/SiO2) separation material was developed using sulfamethoxazole as a template; the specific recognition ability of MIP and appropriate physicochemical properties (abundant Si-OH, suitable pore structure, good stability, etc.) of SiO2 microbeads were combined. The MIP/SiO2 separation materials were characterized carefully. Then, various compounds (such as sulfonamides, ginsenosides, nucleosides, and several pesticides) were used to comprehensively evaluate the chromatographic performances of the MIP/SiO2 column. Furthermore, the chromatographic performances of the MIP/SiO2 column were compared with those of other separation materials (such as non-imprinted polymer-coated silica, C18/SiO2, and bare silica) packed columns. The resolution value of all measured compounds was more than 1.51. The column efficiencies of 13 510 plates per meter (N m-1) for sulfamethoxazole, 11 600 N m-1 for ginsenoside Rd, and 10 510 N m-1 for 2 '-deoxyadenosine were obtained. The acceptable results verified that the MIP/SiO2 column can be applied to separate highly polar drugs such as sulfonamides, ginsenosides, nucleosides, and pesticides. Molecularly imprinted polymer-based chromatographic separation materials, owing to their advantages of unique selectivity, low cost, suitable reproducibility, and acceptable stability, have attracted a great deal of research in different fields.
资助机构	Yantai Science and Technology Bureau ; Science and Technology Innovation Development Plan of Yantai City of China ; Yantai University Student Innovation and Entrepreneurship Training Program
收录类别	SCI
语种	英语
关键词[WOS]	SEPARATION
研究领域[WOS]	Chemistry
WOS记录号	WOS:001241905600001
引用统计	被引频次：1[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	http://ir.yic.ac.cn/handle/133337/35954
专题	中国科学院海岸带环境过程与生态修复重点实验室中国科学院海岸带环境过程与生态修复重点实验室_海岸带环境工程技术研究与发展中心
通讯作者	Xu, Hui; Chen, Lingxin; Song, Zhihua
作者单位	1.Yantai Univ, Sch Pharm, Key Lab Mol Pharmacol & Drug Evaluat, Collaborat Innovat Ctr Adv Drug Delivery Syst & Bi, Yantai 264005, Peoples R China 2.Chinese Acad Sci, Yantai Inst Coastal Zone Res, Shandong Res Ctr Coastal Environm Engn & Technol, CAS Key Lab Coastal Environm Proc & Ecol Remediat,, Yantai 264003, Peoples R China 3.Binzhou Med Coll, Sch Pharm, Yantai 264003, Peoples R China
推荐引用方式 GB/T 7714	Wu, Wenpu,Yu, Cuichi,Sui, Lei,et al. Molecularly imprinted polymer-coated silica microbeads for high-performance liquid chromatography[J]. ANALYST,2024:8.
APA	Wu, Wenpu.,Yu, Cuichi.,Sui, Lei.,Xu, Hui.,Li, Jinhua.,...&Song, Zhihua.(2024).Molecularly imprinted polymer-coated silica microbeads for high-performance liquid chromatography.ANALYST,8.
MLA	Wu, Wenpu,et al."Molecularly imprinted polymer-coated silica microbeads for high-performance liquid chromatography".ANALYST (2024):8.