Low salinity influences the dose-dependent transcriptomic responses of oysters to cadmium

doi:10.1016/j.scitotenv.2024.172919

	Low salinity influences the dose-dependent transcriptomic responses of oysters to cadmium
	Zhan, Junfei 1; Song, Changlin 2,3,4; Wang, Zhiyu 2,3,5; Wu, Huifeng2,3 ; Ji, Chenglong2,3
发表期刊	SCIENCE OF THE TOTAL ENVIRONMENT
ISSN	0048-9697
	2024-06-25
卷号	931 页码:8
关键词	Benchmark dose Cadmium Dose-response relationship Low salinity Pacific oyster
DOI	10.1016/j.scitotenv.2024.172919
通讯作者	Ji, Chenglong([email protected])
英文摘要	Species in estuaries tend to undergo both cadmium (Cd) and low salinity stress. However, how low salinity affects the Cd toxicity has not been fully understood. Investigating the impacts of low salinity on the doseresponse relationships between Cd and biological endpoints has potential to enhance our understanding of the combined effects of low salinity and Cd. In this work, changes in the transcriptomes of Pacific oysters were analyzed following exposure to Cd (5, 20, 80 mu g/L Cd2+) under normal (31.4 psu) and low (15.7 psu) salinity conditions, and then the dose-response relationship between Cd and transcriptome was characterized in a highthroughput manner. The benchmark dose (BMD) of gene expression, as a point of departure (POD), was also calculated based on the fitted dose-response model. We found that low salinity treatment significantly influenced the dose-response relationships between Cd and transcripts in oysters indicated by altered dose-response curves. In details, a total of 219 DEGs were commonly fitted to best models under both normal and low salinity conditions. Nearly three quarters of dose-response curves varied with salinity condition. Some monotonic doseresponse curves in normal salinity condition even were replaced by nonmonotonic curves in low salinity condition. Low salinity treatment decreased the PODs of differentially expressed genes induced by Cd, suggesting
资助机构	National Natural Science Foundation of China ; Shandong Provincial Natural Science Foundation, China ; Fundamental Research Projects of Science and Technology Innovation and Development Plan in Yantai City
收录类别	SCI
语种	英语
关键词[WOS]	METAL POLLUTION ; HORMESIS ; TOXICOLOGY
研究领域[WOS]	Environmental Sciences & Ecology
WOS记录号	WOS:001239510300001
引用统计
文献类型	期刊论文
条目标识符	http://ir.yic.ac.cn/handle/133337/35951
专题	中国科学院海岸带环境过程与生态修复重点实验室中国科学院海岸带环境过程与生态修复重点实验室_海岸带环境过程实验室
通讯作者	Ji, Chenglong
作者单位	1.Ludong Univ, Key Lab Ecol Restorat & Conservat Coastal Wetlands, Inst Adv Study Coastal Ecol, Yantai 264025, Peoples R China 2.Chinese Acad Sci, Yantai Inst Coastal Zone Res YIC, CAS Key Lab Coastal Environm Proc & Ecol Remediat, Yantai 264003, Peoples R China 3.YICCAS, Shandong Key Lab Coastal Environm Proc, Yantai 264003, Peoples R China 4.Univ Chinese Acad Sci, Beijing 100049, Peoples R China 5.Yantai Univ, Sch Ocean, Yantai 264005, Peoples R China
推荐引用方式 GB/T 7714	Zhan, Junfei,Song, Changlin,Wang, Zhiyu,et al. Low salinity influences the dose-dependent transcriptomic responses of oysters to cadmium[J]. SCIENCE OF THE TOTAL ENVIRONMENT,2024,931:8.
APA	Zhan, Junfei,Song, Changlin,Wang, Zhiyu,Wu, Huifeng,&Ji, Chenglong.(2024).Low salinity influences the dose-dependent transcriptomic responses of oysters to cadmium.SCIENCE OF THE TOTAL ENVIRONMENT,931,8.
MLA	Zhan, Junfei,et al."Low salinity influences the dose-dependent transcriptomic responses of oysters to cadmium".SCIENCE OF THE TOTAL ENVIRONMENT 931(2024):8.