Realistic Nanoplastics Induced Pulmonary Damage via the Crosstalk of Ferritinophagy and Mitochondrial Dysfunction

doi:10.1021/acsnano.4c02335

	Realistic Nanoplastics Induced Pulmonary Damage via the Crosstalk of Ferritinophagy and Mitochondrial Dysfunction
	Ji, Yunxia 1,2; Chen, Libang 1; Wang, Yunqing3 ; Zhang, Jinjin 2; Yu, Yue 1; Wang, Meirong 1; Wang, Xiaoyan 1; Liu, Weili 2; Yan, Bing 4; Xiao, Liang5 ; Song, Xiaodong 1; Lv, Changjun 2; Chen, Lingxin1,3,6
发表期刊	ACS NANO
ISSN	1936-0851
	2024-06-13
页码	18
关键词	nanoplastic ferroptosis ferritinophagy pulmonary toxicity mitochondrial damage
DOI	10.1021/acsnano.4c02335
通讯作者	Song, Xiaodong([email protected]) ; Lv, Changjun([email protected]) ; Chen, Lingxin([email protected])
英文摘要	The smaller size fraction of plastics may be more substantially existing and detrimental than larger-sized particles. However, reports on nanoplastics (NPs), especially their airborne occurrences and potential health hazards to the respiratory system, are scarce. Previous studies limit the understanding of their real respiratory effects, since sphere-type polystyrene (PS) nanoparticles differ from NPs occurring in nature with respect to their physicochemical properties. Here, we employ a mechanical breakdown method, producing NPs directly from bulk plastic, preserving NP properties in nature. We report that among four relatively high abundance NP materials PS, polyethylene terephthalate (PET), polyvinyl chloride (PVC), and polyethylene (PE) with a size of 100 nm, PVC induced slightly more severe lung toxicity profiles compared to the other plastics. The lung cytotoxicity of NPs is higher than that of commercial PS NPs and comparable to natural particles silicon dioxide (SiO2) and anatase titanium dioxide (TiO2). Mechanistically, BH3-interacting domain death agonist (Bid) transactivation-mediated mitochondrial dysfunction and nuclear receptor coactivator 4 (NCOA4)-mediated ferritinophagy or ferroptosis are likely common mechanisms of NPs regardless of their chemical composition. This study provides relatively comprehensive data for evaluating the risk of atmospheric NPs to lung health.
资助机构	National Nature Science Foundation of China ; Introduced Innovative R&D Team Project under the The Pearl River Talent Recruitment Program of Guangdong Province ; Natural Science Foundation of Shandong Province ; Start-up Fund for Doctoral Research Program ; Science and Technology Plan Project of Binzhou Medical University ; Regenerative Medicine Research Program of Xu Rongxiang ; The 2023 National Key R&D Plan of the Ministry of Science and Technology Sino US International Cooperation Project ; Taishan Scholar Project Special Funding ; Shandong Province University Youth Innovation Team Project
收录类别	SCI
语种	英语
关键词[WOS]	CELL-DEATH ; FERROPTOSIS ; AUTOPHAGY ; OXIDATION ; RECEPTOR
研究领域[WOS]	Chemistry ; Science & Technology - Other Topics ; Materials Science
WOS记录号	WOS:001247376200001
引用统计	被引频次：1[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	http://ir.yic.ac.cn/handle/133337/35939
专题	中国科学院海岸带环境过程与生态修复重点实验室中国科学院海岸带环境过程与生态修复重点实验室_海岸带环境工程技术研究与发展中心
通讯作者	Song, Xiaodong; Lv, Changjun; Chen, Lingxin
作者单位	1.Binzhou Med Univ, Sch Pharmaceut Sci, Dept Cellular & Genet Med, Yantai 264003, Peoples R China 2.Binzhou Med Univ, Binzhou Med Univ Hosp, Dept Resp & Crit Care Med, Binzhou 256603, Peoples R China 3.Chinese Acad Sci, Key Lab Coastal Environm Proc & Ecol Remediat, Yantai Inst Coastal Zone Res, Yantai 264003, Peoples R China 4.Guangzhou Univ, Inst Environm Res Greater Bay Area, Key Lab Water Qual & Conservat Pearl River Delta, Minist Educ, Guangzhou 510006, Peoples R China 5.Naval Med Univ, Mil Med Univ 2, Fac Naval Med, Shanghai 200433, Peoples R China 6.Qingdao Marine Sci & Technol Ctr, Lab Marine Biol & Biotechnol, Qingdao 266237, Peoples R China
推荐引用方式 GB/T 7714	Ji, Yunxia,Chen, Libang,Wang, Yunqing,et al. Realistic Nanoplastics Induced Pulmonary Damage via the Crosstalk of Ferritinophagy and Mitochondrial Dysfunction[J]. ACS NANO,2024:18.
APA	Ji, Yunxia.,Chen, Libang.,Wang, Yunqing.,Zhang, Jinjin.,Yu, Yue.,...&Chen, Lingxin.(2024).Realistic Nanoplastics Induced Pulmonary Damage via the Crosstalk of Ferritinophagy and Mitochondrial Dysfunction.ACS NANO,18.
MLA	Ji, Yunxia,et al."Realistic Nanoplastics Induced Pulmonary Damage via the Crosstalk of Ferritinophagy and Mitochondrial Dysfunction".ACS NANO (2024):18.