Enhanced Superhydrophobic Substrate-Based 3D SERS Platform for a Portable Raman Spectrometer-Assisted Drug Detection in Plasma

doi:10.1021/acsanm.4c02202

	Enhanced Superhydrophobic Substrate-Based 3D SERS Platform for a Portable Raman Spectrometer-Assisted Drug Detection in Plasma
	Lv, Bingqian 1; Wang, Yunqing2 ; Mei, Rongchao 3; Li, Yan1 ; Zhao, Xizhen 2,4; Yuan, Qi 2,4; Xu, Hui 1; Chen, Lingxin2,5
发表期刊	ACS APPLIED NANO MATERIALS
	2024-06-14
卷号	7 期号:12 页码:14665-14672
关键词	superhydrophobic substrate surface-enhanced Raman spectroscopy 3D hotspot blood drug detection portableRaman spectrometer
DOI	10.1021/acsanm.4c02202
通讯作者	Wang, Yunqing([email protected]) ; Xu, Hui([email protected]) ; Chen, Lingxin([email protected])
英文摘要	In situ, fast, sensitive detection of drugs in blood is in great demand in many clinical scenarios. Surface-enhanced Raman spectroscopy (SERS) has shown great potential in drug analysis; however, achieving highly sensitive detection using a portable Raman instrument is still challenging. Herein, a superhydrophobic silver-film-assisted 3D SERS platform was proposed for sensitive detection of drugs in plasma. The superhydrophobic silver film was prepared through the self-assembly of silver nanoparticles (Ag NPs) at the liquid-liquid interface. Gold-silver core-shell (Au@Ag) nanoparticles (NPs), encoded with an internal standard signal, were mixed with the plasma sample. The mixture formed nanocomposites on the superhydrophobic silver film, creating abundant 3D hotspots that greatly enhanced the signal of the analytes. The 3D platform enabled the detection of crystal violet as low as 10(-13) M, and a relative standard deviation (RSD) of 13.4% using a research-grade Raman spectrometer. Furthermore, mitoxantrone and methylene blue drug analysis in plasma was performed by using a portable Raman spectrometer, which could be detected at as low as 8 x 10(-10) and 3 x 10(-8) M, respectively, with an improved signal repeatability (RSD 2.5%). Based on this technique, the pharmacokinetics of the two drugs postintravenous injection in mice was investigated. This work provided a facile and sensitive protocol for plasma drug analysis, showing great promise for the popularization of portable Raman spectroscopy in real clinical applications.
资助机构	National Natural Science Foundation of China ; National Natural Science Foundation of China ; Instrument Developing Project of the Chinese Academy of Sciences ; Taishan Scholar Project Special Funding ; Special Fund for Leading Scholar Program of Yantai
收录类别	SCI
语种	英语
关键词[WOS]	SURFACE ; MITOXANTRONE ; SILVER ; PHARMACOKINETICS
研究领域[WOS]	Science & Technology - Other Topics ; Materials Science
WOS记录号	WOS:001248677200001
引用统计
文献类型	期刊论文
条目标识符	http://ir.yic.ac.cn/handle/133337/35912
专题	中国科学院海岸带环境过程与生态修复重点实验室中国科学院海岸带环境过程与生态修复重点实验室_海岸带环境工程技术研究与发展中心
通讯作者	Wang, Yunqing; Xu, Hui; Chen, Lingxin
作者单位	1.Yantai Univ, Collaborat Innovat Ctr Adv Drug Delivery Syst & Bi, Sch Pharm, Key Lab Mol Pharmacol & Drug Evaluat,Minist Educ, Yantai 264005, Peoples R China 2.Chinese Acad Sci, CAS Key Lab Coastal Environm Proc & Ecol Remediat, Yantai Inst Coastal Zone Res, Yantai 264003, Peoples R China 3.Binzhou Med Univ, Sch Pharm, Yantai 264003, Peoples R China 4.Univ Chinese Acad Sci, Beijing 100049, Peoples R China 5.Qingdao Natl Lab Marine Sci & Technol, Lab Marine Biol & Biotechnol, Qingdao 266237, Peoples R China
推荐引用方式 GB/T 7714	Lv, Bingqian,Wang, Yunqing,Mei, Rongchao,et al. Enhanced Superhydrophobic Substrate-Based 3D SERS Platform for a Portable Raman Spectrometer-Assisted Drug Detection in Plasma[J]. ACS APPLIED NANO MATERIALS,2024,7(12):14665-14672.
APA	Lv, Bingqian.,Wang, Yunqing.,Mei, Rongchao.,Li, Yan.,Zhao, Xizhen.,...&Chen, Lingxin.(2024).Enhanced Superhydrophobic Substrate-Based 3D SERS Platform for a Portable Raman Spectrometer-Assisted Drug Detection in Plasma.ACS APPLIED NANO MATERIALS,7(12),14665-14672.
MLA	Lv, Bingqian,et al."Enhanced Superhydrophobic Substrate-Based 3D SERS Platform for a Portable Raman Spectrometer-Assisted Drug Detection in Plasma".ACS APPLIED NANO MATERIALS 7.12(2024):14665-14672.