Shining light on carbon dots: Toward enhanced antibacterial activity for biofilm disruption

doi:10.1002/biot.202400156

	Shining light on carbon dots: Toward enhanced antibacterial activity for biofilm disruption
	Zhang, Qingsong 1; Fu, Jianxin 1; Lin, Hong 1; Xuan, Guanhua 1; Zhang, Weiwei 2; Chen, Lingxin3 ; Wang, Guoqing 1,4
发表期刊	BIOTECHNOLOGY JOURNAL
ISSN	1860-6768
	2024-05-01
卷号	19 期号:5 页码:11
关键词	antibacterial mechanism biofilm carbon dot one-step reaction photoactivation
DOI	10.1002/biot.202400156
通讯作者	Xuan, Guanhua([email protected]) ; Wang, Guoqing([email protected])
英文摘要	In spite of tremendous efforts dedicated to addressing bacterial infections and biofilm formation, the post-antibiotic ear continues to witness a gap between the established materials and an easily accessible yet biocompatible antibacterial reagent. Here we show carbon dots (CDs) synthesized via a single hydrothermal process can afford promising antibacterial activity that can be further enhanced by exposure to light. By using citric acid and polyethyleneimine as the precursors, the photoluminescence CDs can be produced within a one-pot, one-step hydrothermal reaction in only 2 h. The CDs demonstrate robust antibacterial properties against both Gram-positive and Gram-negative bacteria and, notably, a considerable enhancement of antibacterial effect can be observed upon photo-irradiation. Mechanistic insights reveal that the CDs generate singlet oxygen (1O2) when exposed to light, leading to an augmented reactive oxygen species level. The approach for disruption of biofilms and inhibition of biofilm formation by using the CDs has also been established. Our findings present a potential solution to combat antibacterial resistance and offer a path to reduce dependence on traditional antibiotics. Shining carbon dots (CDs) produced by a single-step hydrothermal method can afford enhanced antibacterial activity against both Gram-positive and Gram-negative bacteria. Mechanistic insights reveal that the CDs generate singlet oxygen (1O2) under light irradiation, contributing to an augmented ROS level, facilitating disruption of biofilms and inhibition of biofilm formation. image
资助机构	National Natural-Science Foundation of China ; Special Fund for the Qingdao Science and Technology Program of Public Wellbeing
收录类别	SCI
语种	英语
关键词[WOS]	SALMONELLA-TYPHIMURIUM ; STAPHYLOCOCCUS-AUREUS ; QUANTUM DOTS ; OXYGEN ; NANOPARTICLES ; RESISTANCE ; FILMS
研究领域[WOS]	Biochemistry & Molecular Biology ; Biotechnology & Applied Microbiology
WOS记录号	WOS:001232562300001
引用统计
文献类型	期刊论文
条目标识符	http://ir.yic.ac.cn/handle/133337/35648
专题	中国科学院海岸带环境过程与生态修复重点实验室中国科学院海岸带环境过程与生态修复重点实验室_海岸带环境工程技术研究与发展中心
通讯作者	Xuan, Guanhua; Wang, Guoqing
作者单位	1.Ocean Univ China, Coll Food Sci & Engn, State Key Lab Marine Food Proc & Safety Control, Qingdao, Peoples R China 2.Ningbo Univ, Coll Marine Sci, Ningbo, Peoples R China 3.Chinese Acad Sci, Yantai Inst Coastal Zone Res, Res Ctr Coastal Environm Engn & Technol, CAS Key Lab Coastal Environm Proc & Ecol Remediat, Yantai, Peoples R China 4.Qingdao Natl Lab Marine Sci & Technol, Lab Marine Drugs & Bioprod, Qingdao, Peoples R China
推荐引用方式 GB/T 7714	Zhang, Qingsong,Fu, Jianxin,Lin, Hong,et al. Shining light on carbon dots: Toward enhanced antibacterial activity for biofilm disruption[J]. BIOTECHNOLOGY JOURNAL,2024,19(5):11.
APA	Zhang, Qingsong.,Fu, Jianxin.,Lin, Hong.,Xuan, Guanhua.,Zhang, Weiwei.,...&Wang, Guoqing.(2024).Shining light on carbon dots: Toward enhanced antibacterial activity for biofilm disruption.BIOTECHNOLOGY JOURNAL,19(5),11.
MLA	Zhang, Qingsong,et al."Shining light on carbon dots: Toward enhanced antibacterial activity for biofilm disruption".BIOTECHNOLOGY JOURNAL 19.5(2024):11.