Combinatorial accumulation, stress response, detoxification and synaptic transmission effects of cadmium and selenium in clams <i>Ruditapes philippinarum</i>

doi:10.1016/j.aquatox.2024.107075

	Combinatorial accumulation, stress response, detoxification and synaptic transmission effects of cadmium and selenium in clams Ruditapes philippinarum
	Zhang, Xiaoyu 1,3; Sun, Tao 1,3; Li, Fei1,4 ; Ji, Chenglong1,2,4 ; Liu, Hongmei1,4 ; Wu, Huifeng1,2,4
发表期刊	AQUATIC TOXICOLOGY
ISSN	0166-445X
	2024-10-01
卷号	275 页码:16
关键词	Cadmium Selenium Ruditapes philippinarum Toxicological mechanism Interaction
DOI	10.1016/j.aquatox.2024.107075
通讯作者	Wu, Huifeng([email protected])
英文摘要	This study investigated the toxicological effects and mechanisms of cadmium (Cd) (5 and 50 mu g/L) and selenium (Se) (3 and 30 mu g/L) at environmentally relevant concentrations on the gills and digestive glands of clams Ruditapes philippinarum. Results indicated that Cd and Se could tissue-specifically impact osmoregulation, energy metabolism, and synaptic transmission in the gills and digestive glands of clams. After exposure to 50 mu g/L Cd, the digestive glands of clams up-regulated the expression of methionine-gamma-lyase and metallothionein for detoxification. Clam digestive glands exposed to 3 mu g/L Se up-regulated the expression of catalase and glutathione peroxidase to alleviate oxidative stress, and down-regulated the expression of selenide-water dikinase to reduce the conversion of inorganic Se. Additionally, the interaction mode between Cd and Se largely depended on their molar ratio, with a ratio of 11.71 (50 mu g/L Cd + 3 mu g/L Se) demonstrated to be particularly harmful, as manifested by significantly more lesions, oxidative stress, and detoxification demand in clams than those exposed to Cd or Se alone. Collectively, this study revealed the complex interaction patterns and mechanisms of Cd and Se on clams, providing a reference for exploring their single and combined toxicity.
资助机构	National Natural Science Foundation of China ; Young Taishan Scholars Program of Shandong Province
收录类别	SCI
语种	英语
关键词[WOS]	OXIDATIVE STRESS ; METAL CONTAMINATION ; INDUCED APOPTOSIS ; DIETARY SELENIUM ; TOXICITY ; COPPER ; CD ; SE ; THIOREDOXIN ; INSIGHTS
研究领域[WOS]	Marine & Freshwater Biology ; Toxicology
WOS记录号	WOS:001312289700001
引用统计
文献类型	期刊论文
条目标识符	http://ir.yic.ac.cn/handle/133337/35642
专题	中国科学院海岸带环境过程与生态修复重点实验室中国科学院海岸带环境过程与生态修复重点实验室_海岸带环境过程实验室
通讯作者	Wu, Huifeng
作者单位	1.Chinese Acad Sci, Yantai Inst Coastal Zone Res, CAS Key Lab Coastal Environm Proc & Ecol Remediat, YICCAS,Shandong Key Lab Coastal Environm Proc, Yantai 264003, Peoples R China 2.Laoshan Lab, Funct Lab Marine Fisheries Sci & Food Prod Proc, Qingdao 266237, Peoples R China 3.Univ Chinese Acad Sci, Beijing 100049, Peoples R China 4.Chinese Acad Sci, Ctr Ocean Mega Sci, Qingdao 266071, Peoples R China
推荐引用方式 GB/T 7714	Zhang, Xiaoyu,Sun, Tao,Li, Fei,et al. Combinatorial accumulation, stress response, detoxification and synaptic transmission effects of cadmium and selenium in clams Ruditapes philippinarum[J]. AQUATIC TOXICOLOGY,2024,275:16.
APA	Zhang, Xiaoyu,Sun, Tao,Li, Fei,Ji, Chenglong,Liu, Hongmei,&Wu, Huifeng.(2024).Combinatorial accumulation, stress response, detoxification and synaptic transmission effects of cadmium and selenium in clams Ruditapes philippinarum.AQUATIC TOXICOLOGY,275,16.
MLA	Zhang, Xiaoyu,et al."Combinatorial accumulation, stress response, detoxification and synaptic transmission effects of cadmium and selenium in clams Ruditapes philippinarum".AQUATIC TOXICOLOGY 275(2024):16.