Improvement of the selectivity of a molecularly imprinted polymer-based potentiometric sensor by using a specific functional monomer

doi:10.1016/j.aca.2024.342412

YIC-IR

	Improvement of the selectivity of a molecularly imprinted polymer-based potentiometric sensor by using a specific functional monomer
	Wang, Junhao 1,2; Liang, Rongning1 ; Qin, Wei1,3,4
发表期刊	ANALYTICA CHIMICA ACTA
ISSN	0003-2670
	2024-04-15
卷号	1298 页码:7
关键词	Potentiometric sensor Molecularly imprinted polymer Specific functional monomer Density functional theory Bisphenol A
DOI	10.1016/j.aca.2024.342412
通讯作者	Liang, Rongning([email protected]) ; Qin, Wei([email protected])
英文摘要	Potentiometric sensors based on the molecularly imprinted polymers (MIPs) as the receptors have been successfully developed for determination of various organic and biological species. However, these MIP receptors may suffer from problems of low selectivity. Especially, it would be difficult to distinguish the target analyte from its structurally similar interferents. In this work, we propose a novel strategy that using specific functional monomer to fabricate MIP with high selectivity towards the target molecule. The density functional theory calculations are used to investigate the interactions between the template and the functional monomer. The binding energy between the template and functional monomer can be used as the criterion for identifying the optimal monomer. As a proof-of-concept experiment, bisphenol A (BPA) is chosen as the template and the MIP is synthesized by the precipitation polymerization method using the specific allyl-beta-cyclodextrin (allyl-beta-CD) with high affinity towards BPA as the functional monomer. The high-affinity MIP is employed as the receptor for the construction of the potentiometric sensor. The proposed potentiometric sensor based on the MIP using allyl-beta-CD as the functional monomer shows an improved response performance in terms of selectivity and sensitivity compared to the conventional potentiometric sensor based on the MIP with the common monomer (i.e., methacrylic acid). This allyl-beta-CD MIP-based potentiometric sensor shows a detection limit of 0.29 mu M for BPA, which is about one order of magnitude lower than that obtained by the conventional MIP-based potentiometric sensor. We believe that utilizing a functional monomer with specific recognition ability towards target in the fabrication of MIP could provide an appealing way to construct highly selective MIP-based electrochemical and optical sensors.
资助机构	National Natural Science Foundation of China ; Key R & D Program of Shandong Province ; Key Deployment Project of Centre for Ocean Mega -Research of Science, Chinese Academy of Sciences ; Taishan Scholar Program of Shandong Province ; Special Supporting Project of Yantai
收录类别	SCI
语种	英语
关键词[WOS]	MEMBRANE ELECTRODES ; RECOGNITION ; CYCLODEXTRIN ; DESIGN
研究领域[WOS]	Chemistry
WOS记录号	WOS:001209190700001
引用统计	被引频次：3[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	http://ir.yic.ac.cn/handle/133337/35344
专题	中国科学院烟台海岸带研究所
通讯作者	Liang, Rongning; Qin, Wei
作者单位	1.Chinese Acad Sci, Yantai Inst Coastal Zone Res YIC, CAS Key Lab Coastal Environm Proc & Ecol Remediat, Shandong Key Lab Coastal Environm Proc,YICCAS, Yantai 264003, Shandong, Peoples R China 2.Univ Chinese Acad Sci, Beijing 100049, Peoples R China 3.Qingdao Marine Sci & Technol Ctr, Lab Marine Biol & Biotechnol, Qingdao 266237, Shandong, Peoples R China 4.Chinese Acad Sci, Ctr Ocean Mega Sci, Qingdao 266071, Shandong, Peoples R China
推荐引用方式 GB/T 7714	Wang, Junhao,Liang, Rongning,Qin, Wei. Improvement of the selectivity of a molecularly imprinted polymer-based potentiometric sensor by using a specific functional monomer[J]. ANALYTICA CHIMICA ACTA,2024,1298:7.
APA	Wang, Junhao,Liang, Rongning,&Qin, Wei.(2024).Improvement of the selectivity of a molecularly imprinted polymer-based potentiometric sensor by using a specific functional monomer.ANALYTICA CHIMICA ACTA,1298,7.
MLA	Wang, Junhao,et al."Improvement of the selectivity of a molecularly imprinted polymer-based potentiometric sensor by using a specific functional monomer".ANALYTICA CHIMICA ACTA 1298(2024):7.