Fatty acid esters of hydroxy fatty acids: A potential treatment for obesity-related diseases

doi:10.1111/obr.13735

YIC-IR

	Fatty acid esters of hydroxy fatty acids: A potential treatment for obesity-related diseases
	Li, Lili1,2 ; Wang, Ping 1,2; Jiao, Xudong1 ; Qin, Song1 ; Liu, Zhengyi1 ; Ye, Yanrui 3; Song, Yipeng 4,6; Hou, Hu 5,7
发表期刊	OBESITY REVIEWS
ISSN	1467-7881
	2024-03-10
页码	11
关键词	adipose tissue diabetes fatty acid esters of hydroxy fatty acids inflammation structure-activity relationship
DOI	10.1111/obr.13735
通讯作者	Song, Yipeng([email protected]) ; Hou, Hu([email protected])
英文摘要	Obesity, a burgeoning worldwide health system challenge, is associated with multiple chronic diseases, including diabetes and chronic inflammation. Fatty acid esters of hydroxy fatty acids (FAHFAs) are newly identified lipids with mitigating and anti-inflammatory effects in diabetes. Increasing work has shown that FAHFAs exert antioxidant activity and enhance autophagy in neuronal cells and cardiomyocytes. We systematically summarized the biological activities of FAHFAs, including their regulatory effects on diabetes and inflammation, antioxidant activity, and autophagy augmentation. Notably, the structure-activity relationships and potential biosynthesis of FAHFAs are thoroughly discussed. FAHFAs also showed potential roles as diagnostic biomarkers. FAHFAs are a class of resources with promising applications in the biomedical field that require in-depth research and hotspot development, as their structure has not been fully resolved and their biological activity has not been fully revealed.
资助机构	National Key Research and Development Program
收录类别	SCI
语种	英语
关键词[WOS]	DE-NOVO LIPOGENESIS ; INSULIN-RESISTANCE ; ENERGY-METABOLISM ; OXIDATIVE STRESS ; GLUCOSE ; ADIPOCYTES ; FAHFAS ; GPR40 ; INFLAMMATION ; LIPIDOMICS
研究领域[WOS]	Endocrinology & Metabolism
WOS记录号	WOS:001181626800001
引用统计	被引频次：1[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	http://ir.yic.ac.cn/handle/133337/34908
专题	中国科学院烟台海岸带研究所
通讯作者	Song, Yipeng; Hou, Hu
作者单位	1.Chinese Acad Sci, Yantai Inst Coastal Zone Res, Yantai, Peoples R China 2.Shandong Univ Tradit Chinese Med, Qingdao Acad Chinese Med Sci, Qingdao, Peoples R China 3.South China Univ Technol, Sch Biol & Biol Engn, Guangzhou, Peoples R China 4.Yantai Yuhuangding Hosp, Yantai, Peoples R China 5.Ocean Univ China, Qingdao, Peoples R China 6.Yantai Yuhuangding Hosp, 20 Yudong Rd, Yantai 264000, Shandong, Peoples R China 7.Ocean Univ China, 5 Yushan Rd, Qingdao 266003, Shandong, Peoples R China
推荐引用方式 GB/T 7714	Li, Lili,Wang, Ping,Jiao, Xudong,et al. Fatty acid esters of hydroxy fatty acids: A potential treatment for obesity-related diseases[J]. OBESITY REVIEWS,2024:11.
APA	Li, Lili.,Wang, Ping.,Jiao, Xudong.,Qin, Song.,Liu, Zhengyi.,...&Hou, Hu.(2024).Fatty acid esters of hydroxy fatty acids: A potential treatment for obesity-related diseases.OBESITY REVIEWS,11.
MLA	Li, Lili,et al."Fatty acid esters of hydroxy fatty acids: A potential treatment for obesity-related diseases".OBESITY REVIEWS (2024):11.