Effect of Hydrophobic Chain Length in Amphiphilic Chitosan Conjugates on Intracellular Drug Delivery and Smart Drug Release of Redox-Responsive Micelle

doi:10.3390/md22010018

YIC-IR

	Effect of Hydrophobic Chain Length in Amphiphilic Chitosan Conjugates on Intracellular Drug Delivery and Smart Drug Release of Redox-Responsive Micelle
	Yuan, Yuting 1,2,3; Tan, Wenqiang1,3 ; Mi, Yingqi 1,3; Wang, Linqing 1,2,3; Qi, Zhen 4; Guo, Zhanyong1,2,3
发表期刊	MARINE DRUGS
	2024
卷号	22 期号:1 页码:18
关键词	different hydrophobic chain length low molecular weight chitosan trigger-release
DOI	10.3390/md22010018
通讯作者	Tan, Wenqiang([email protected]) ; Guo, Zhanyong([email protected])
英文摘要	Three redox-sensitive nanocarriers were rationally designed based on amphiphilic low molecular weight chitosan-cystamine-octylamine/dodecylamin/cetylamine (LC-Cys-OA, LC-Cys-DA, LC-Cys-CA) conjugates containing disulfide linkage for maximizing therapeutic effect by regulating hydrophobic interaction. The resultant spherical micelles had the characteristics of low CMC, suitable size, excellent biosafety and desired stability. The drug-loaded micelles were fabricated by embedding doxorubicin (Dox) into the hydrophobic cores. The effect of hydrophobic chain lengths of amphiphilic conjugates on encapsulation capacity, redox sensitivity, trigger-release behavior, cellular uptake efficacy, antitumor effect and antimigratory activity of Dox-loaded micelles was systematically investigated. Studies found that Dox-loaded LC-Cys-CA micelle had superior loading capacity and enhanced redox sensitivity compared with the other two micelles. Release assay indicated that the three Dox-loaded micelles maintained sufficiently stability in normal blood circulation but rapidly disintegrated in tumor cells. More importantly, the LC-Cys-CA micelle with a longer hydrophobic chain length exhibited a higher accumulative Dox release percentage than the other two micelles. Additionally, an increase in hydrophobic chain lengths of amphiphilic conjugates improved cellular uptake efficiency, antitumor effect and antimigration activity of Dox-loaded micelles, which could be explained by enhanced loading ability and redox sensitivity. Our research was expected to provide a viable platform for achieving a desired therapeutic efficacy via the alteration of hydrophobic interaction.
资助机构	Youth Innovation Promotion Association CAS
收录类别	SCI
语种	英语
关键词[WOS]	POLYMERIC MICELLES ; BLOCK-COPOLYMERS ; ANTICANCER DRUG ; SENSITIVE MICELLES ; MIXED MICELLES ; CO-DELIVERY ; CANCER ; DOCETAXEL
研究领域[WOS]	Pharmacology & Pharmacy
WOS记录号	WOS:001150853800001
引用统计	被引频次：3[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	http://ir.yic.ac.cn/handle/133337/34840
专题	中国科学院烟台海岸带研究所
通讯作者	Tan, Wenqiang; Guo, Zhanyong
作者单位	1.Chinese Acad Sci, Yantai Inst Coastal Zone Res, Key Lab Coastal Biol & Bioresource Utilizat, Yantai 264003, Peoples R China 2.Univ Chinese Acad Sci, Beijing 100049, Peoples R China 3.Chinese Acad Sci, Ctr Ocean Mega Sci, Qingdao 266071, Peoples R China 4.Yantai Univ, Coll Life Sci, Yantai 264005, Peoples R China
推荐引用方式 GB/T 7714	Yuan, Yuting,Tan, Wenqiang,Mi, Yingqi,et al. Effect of Hydrophobic Chain Length in Amphiphilic Chitosan Conjugates on Intracellular Drug Delivery and Smart Drug Release of Redox-Responsive Micelle[J]. MARINE DRUGS,2024,22(1):18.
APA	Yuan, Yuting,Tan, Wenqiang,Mi, Yingqi,Wang, Linqing,Qi, Zhen,&Guo, Zhanyong.(2024).Effect of Hydrophobic Chain Length in Amphiphilic Chitosan Conjugates on Intracellular Drug Delivery and Smart Drug Release of Redox-Responsive Micelle.MARINE DRUGS,22(1),18.
MLA	Yuan, Yuting,et al."Effect of Hydrophobic Chain Length in Amphiphilic Chitosan Conjugates on Intracellular Drug Delivery and Smart Drug Release of Redox-Responsive Micelle".MARINE DRUGS 22.1(2024):18.