TAF15 promotes cell proliferation, migration and invasion of gastric cancer via activation of the RAF1

YIC-IR

	TAF15 promotes cell proliferation, migration and invasion of gastric cancer via activation of the RAF1
	Li Tang; Chengming Guo; Xu Li; Bo Zhang; Liuye Huang
发表期刊	SCIENTIFIC REPORTS
ISSN	2045-2322
卷号	13 期号:1
英文摘要	TATA-box-binding protein-associated Factor 15 (TAF15), a member of the FUS/EWS/TAF15 (FET) family, contributes to the progression of various tumours. However, the role and molecular mechanism of TAF15 in gastric cancer (GC) progression are still unknown. In this study, we found that TAF15 was significantly upregulated in GC tumour tissues and cell lines. Overexpression of TAF15 was associated with a larger tumour size, high pathologic stage and high T stage of GC. TAF15 knockdown suppressed the proliferation, migration and invasion of GC cells in vitro and inhibited the tumour growth in vivo. Additionally, TAF15 knockdown led to the significant reductions in the phosphorylation levels of RAF1, MEK and ERK1/2, while total RAF1, MEK and ERK1/2 exhibited no significant change in GC cell lines. In summary, TAF15 is overexpressed in GC tumour tissues and cell lines, and promotes cell proliferation, migration and invasion in GC via the RAF1/MEK/ERK signaling pathway, which suggests that TAF15 might be a potential molecular diagnostic marker or therapeutic target for GC.
语种	英语
文献类型	期刊论文
条目标识符	http://ir.yic.ac.cn/handle/133337/34539
专题	中国科学院烟台海岸带研究所
作者单位	中国科学院烟台海岸带研究所
推荐引用方式 GB/T 7714	Li Tang,Chengming Guo,Xu Li,et al. TAF15 promotes cell proliferation, migration and invasion of gastric cancer via activation of the RAF1[J]. SCIENTIFIC REPORTS,13(1).
APA	Li Tang,Chengming Guo,Xu Li,Bo Zhang,&Liuye Huang.
MLA	Li Tang,et al."TAF15 promotes cell proliferation, migration and invasion of gastric cancer via activation of the RAF1".SCIENTIFIC REPORTS 13.1